Expression of Inflammatory Cytokines TNF-α and IL-6 in Patients with Chronic Thromboembolic Pulmonary Hypertension and Their Clinical Significance

Jian XU; Le LI; Yan-li HUANG; Jin-shu GUI; Ya-hong LI; Lei MA

doi:10.12259/j.issn.2095-610X.S20210631

Volume 42 Issue 6

Jul. 2021

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Jian XU, Le LI, Yan-li HUANG, Jin-shu GUI, Ya-hong LI, Lei MA. Expression of Inflammatory Cytokines TNF-α and IL-6 in Patients with Chronic Thromboembolic Pulmonary Hypertension and Their Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(6): 119-123. doi: 10.12259/j.issn.2095-610X.S20210631

Citation:

Jian XU, Le LI, Yan-li HUANG, Jin-shu GUI, Ya-hong LI, Lei MA. Expression of Inflammatory Cytokines TNF-α and IL-6 in Patients with Chronic Thromboembolic Pulmonary Hypertension and Their Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(6): 119-123. doi: 10.12259/j.issn.2095-610X.S20210631

Citation:

Jian XU, Le LI, Yan-li HUANG, Jin-shu GUI, Ya-hong LI, Lei MA. Expression of Inflammatory Cytokines TNF-α and IL-6 in Patients with Chronic Thromboembolic Pulmonary Hypertension and Their Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(6): 119-123. doi: 10.12259/j.issn.2095-610X.S20210631

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Expression of Inflammatory Cytokines TNF-α and IL-6 in Patients with Chronic Thromboembolic Pulmonary Hypertension and Their Clinical Significance

doi: 10.12259/j.issn.2095-610X.S20210631

Dept. of Geriatrics，the First Affiliated Hospital of Kunming Medical University，Kunming Yunnan，650032，China

Received Date: 2021-03-27
Available Online: 2021-06-16
Publish Date: 2021-07-21

Abstract

Abstract

Objective To detect the serum levels of the inflammatory factors TNF-α and IL-6 in patients with chronic thromboembolic pulmonary hypertension （CTEPH） and further study their clinical significance in CTEPH. Methods A retrospective analysis was performed on 59 cases of CTEPH patients admitted to our hospital from January 2015 to January 2020. According to the echocardiography, the patients were divided into the group with normal right heart function （observation group 1） and the group with injured right heart function （observation group 2）. A total of 30 patients with no PH who met the standards were selected as the control group.Serum levels of inflammatory cytokines TNF-α, IL-6 and NT-proBNP were detected. Pulmonary artery systolic pressure （PASP） was measured by echocardiography. Results The serum concentrations of TNF-α, IL-6 and NT-proBNP in the control group, observation group 1 and observation group 2 increased successively. The concentrations of TNF-αwere （13.54±6.37） pg/mL, （25.20±11.87） pg/mL and （40.75±1.74） pg/mL, and the concentrations of IL-6 were （6.04±2.89）pg/mL, （8.56±4.25）pg/mL and（4.95±5.24）pg/mL, respectively.The concentrations of NT-proBNP were （265.07±132.47）pg/mL, （719.52±345.23）pg/mL and （1250.00±421.22） pg/mL respectively. There were significant differences in TNF-α, IL-6 and NT-proBNP between groups （P < 0.05）. PASP was also increased successively, which were （32.07±6.15）mmHg, （57.04±11.26）mmHg, and （73.22±11.79） mmHg, respectively. Correlation analysis showed that the levels of TNF-α, lL-6 were significantly correlated with NT-proBNP and PASP （P < 0.05）. Conclusion In patients with CTEPH hypertension, there are high expressions of inflammatory cytokines TNF- and IL-6, and their expression levels can reflect right heart function and pulmonary artery pressure.
- Chronic thromboembolic pulmonary hypertension,
- Inflammatory factors,
- Right heart function,
- Pulmonary arterial systolic pressure

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