Effect of Norathyriol on Uric Acid Excretion Indicators in Hyperuricemic Nephropathy Rats

Ping-fen YANG; Hua LIN; Li-hui GAO; Ling LI; Meng-wei CHENG; Juan YANG; Ge WANG; Yan-fen NIU

doi:10.12259/j.issn.2095-610X.S20210633

Volume 42 Issue 6

Jul. 2021

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Ping-fen YANG, Hua LIN, Li-hui GAO, Ling LI, Meng-wei CHENG, Juan YANG, Ge WANG, Yan-fen NIU. Effect of Norathyriol on Uric Acid Excretion Indicators in Hyperuricemic Nephropathy Rats[J]. Journal of Kunming Medical University, 2021, 42(6): 16-21. doi: 10.12259/j.issn.2095-610X.S20210633

Citation:

Ping-fen YANG, Hua LIN, Li-hui GAO, Ling LI, Meng-wei CHENG, Juan YANG, Ge WANG, Yan-fen NIU. Effect of Norathyriol on Uric Acid Excretion Indicators in Hyperuricemic Nephropathy Rats[J]. Journal of Kunming Medical University, 2021, 42(6): 16-21. doi: 10.12259/j.issn.2095-610X.S20210633

Citation:

Ping-fen YANG, Hua LIN, Li-hui GAO, Ling LI, Meng-wei CHENG, Juan YANG, Ge WANG, Yan-fen NIU. Effect of Norathyriol on Uric Acid Excretion Indicators in Hyperuricemic Nephropathy Rats[J]. Journal of Kunming Medical University, 2021, 42(6): 16-21. doi: 10.12259/j.issn.2095-610X.S20210633

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Effect of Norathyriol on Uric Acid Excretion Indicators in Hyperuricemic Nephropathy Rats

doi: 10.12259/j.issn.2095-610X.S20210633

Biomedical Engineering Research Center of Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2021-03-18
Available Online: 2021-07-03
Publish Date: 2021-07-21

Abstract

Abstract

Objective To study the effect of norathyriol on uric acid excretion indicators in hyperuricemic nephropathy （HN） rats induced by adenine and potassium oxazinate. Method Sixty male SD rats were randomly divided into normal group, model group, norathyriol 1.0, 2.0, 4.0 mg/kg group, positive control benzbromarone 12.5 mg/kg group, each group of 10, according to 20 mL/kg volume were given respectively adenine （0.1 g/kg） and potassium oxonate （1.5 g/kg） suspension after 1 hour, and according to 10 ml/kg volume were given the test drug was administered once a day for 28 days. The gain weight of the rats was monitored weekly, and the urine was collected for 24 hours in themetabolic cage at 7, 14, 21 and 28 days after the administration. The urine volume, urine uric acid and urine creatinine were measured. At the end of the experiment, blood uric acid, serum creatinine and organ weight were measured. Uric acid excretion indicators were calculated: The fractional excretion of uric acid （FEUA）, the amount of 24 h uric acid excretion （24 h U_UA）, creatinine clearance （C_Cr）, uric acid clearance （Cur）, glomerular load of uric acid （FLur）, excretion of uric acid per volume of glomerular filtration （EurGF） and ratio of urinary uric acid to creatinine. Results Norathyriol groups significantly reduced the level of serum uric acid in rats with hyperuricemic nephropathy. After 7 days of administration of 2.0 mg/kg norathyriol, 24 h UUA significantly increased （P < 0.05）. After 14 days and 28 days of administration of 2.0 mg/kg norathyriol, FEUA and Cur significantly increased （P < 0.05, P < 0.01）. Conclusion Norathyriol could affect FEUA and Cur, the sensitive indicators of uric acid excretion of rats with hyperuricemic nephropathy.
- Norathyriol,
- Hyperuricemic nephropathy,
- Uric acid excretion indicators,
- Fractional excretion of uric acid,
- Uric acid clearance

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