Pharmacokinetics of Etomidate in Patients with Different Degrees of Burn

Feng YUANG; Shu-lan JIAO; Rui CHEN; Bing-bing XIANG; Yong-yu SI

doi:10.12259/j.issn.2095-610X.S20210637

Volume 42 Issue 6

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(6): 94-97

Feng YUANG, Shu-lan JIAO, Rui CHEN, Bing-bing XIANG, Yong-yu SI. Pharmacokinetics of Etomidate in Patients with Different Degrees of Burn[J]. Journal of Kunming Medical University, 2021, 42(6): 94-97. doi: 10.12259/j.issn.2095-610X.S20210637

Citation:

Feng YUANG, Shu-lan JIAO, Rui CHEN, Bing-bing XIANG, Yong-yu SI. Pharmacokinetics of Etomidate in Patients with Different Degrees of Burn[J]. Journal of Kunming Medical University, 2021, 42(6): 94-97. doi: 10.12259/j.issn.2095-610X.S20210637

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Pharmacokinetics of Etomidate in Patients with Different Degrees of Burn

doi: 10.12259/j.issn.2095-610X.S20210637

1.
Dept. of Anesthesiology，Chengdu Fifth People’s Hospital，Chengdu Sichuan 611130
2.
Dept. of Anesthesiology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2021-04-19
Available Online: 2021-07-09
Publish Date: 2021-07-21

Abstract

Abstract

Objective To study the pharmacokinetics of etomidate in patients with varying degrees of burns. Methods 45 burn patients who underwent escharetomy and skin grafting, and they were divided into A.B.C three groups according to light, mooderate and severe burns. Anesthesia induction: All the 45 patients were given target controlled infusion of sufentanil （target blood concentration 0.4 ng/ml）. Intravenous infusion of etomidate began after 15 minutes （T_t15）, the dosage of etomidate was 0.4 mg/kg, and the pump infusion was set at the end of 2 minutes, and supplemented by rocuroniumto, dexmedetomidine and sevoflurane maintaining the BIS at 40～60. Before anesthesia （basis）, starting TCI sufentanil 20, 30, 40, 50, 60, 90 min and stopping TCI sufentanil （Stop） and stopping TCI sufentanil 1, 3, 5, 8, 10, 20, 30 min.arterial blood were collected.Plasma concentration of etomidate was determined. Finally, the pharmacokinetic parameters of each group were calculated. Results Pharmacokinetic parameters of etomidate K₃₁, CL₁ and CL₃ in group C were smaller than those in group A and group B, （P < 0.05）. V₃, T_{1/2r r} of group C were greater than those of group A and B （P < 0.05）. There was no significant difference between group A and group B in V₃, K₃₁. T_1/2r, CL₁ and CL₃. （P > 0.05）. Conclusion In patients with severe burns, when etomidate was used intraoperatively, K₃₁ became smaller, V₃ increased, CL₁ and CL₃ decreased, T_1/2r was significantly prolonged, and pharmacological effects were enhanced, In clinical work, dosage can be appropriately reduced.
- Burn,
- Etomidate,
- Pharmacokinetics

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References(15)

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