Volume 42 Issue 6
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Article Navigation >  Journal of Kunming Medical University  > 2021  >  42(6): 22-28
Ziyun ZHOU, Yingying WANG, Zhiling YAN, Lingfeng ZHAO, Xi YANG, Jinmei XU, Shao ZHANG. Molecular Epidemiological Investigation of HPV 56 in Precancerous Cervical Cancer Patients in Yunnan Province[J]. Journal of Kunming Medical University, 2023, 44(10): 114-121. doi: 10.12259/j.issn.2095-610X.S20231005
Citation: Zhang-ping ZHOU, Xiao-qiong HE, Ling DUAN, Song TENG, Zhuo-xuan LIANG. Evaluation of Toxicology and Safety of Natural Active Compound Usenamine[J]. Journal of Kunming Medical University, 2021, 42(6): 22-28. doi: 10.12259/j.issn.2095-610X.S20210642
shu

Evaluation of Toxicology and Safety of Natural Active Compound Usenamine

doi: 10.12259/j.issn.2095-610X.S20210642

  • School of Public Health，Kunming Medical University，Kunming Yunnan 650500，China

  • Received Date: 2021-03-16
    Available Online: 2021-07-09
  • Publish Date: 2021-07-21
    Abstract
  •   Objective  To investigate the natural active compound Usenamine [C18H17NO6, 6-acetyl-2-（1-amino-ethylene）-7, 9-dihydroxy-8, 9b-dimethyl-9bH- diphenylfuran -1, 3-dione] is safe to use.  Methods  SPF mice were selected for oral toxicity test, in vivo and in vitro chromosomal aberration test, bone marrow micronucleus test, sperm abnormality test and 30-day feeding test.  Results  Under the research conditions, the maximum tolerated dose （MTD） of the test substance for acute oral toxicity was more than 15000 mg/kg; both in vivo and in vitro chromosomal aberration tests were negative （P > 0.05）; bone marrow micronucleus test results were negative （P > 0.05） The result of sperm deformity test was negative （P > 0.05）; no obvious signs of poisoning were found in the 30-day feeding test, and all the indicators were normal.  Conclusion  Usenamine is safe and has no acute or subacute toxic effects, and genetic toxicity.
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