Evaluation of Toxicology and Safety of Natural Active Compound Usenamine

Zhang-ping ZHOU; Xiao-qiong HE; Ling DUAN; Song TENG; Zhuo-xuan LIANG

doi:10.12259/j.issn.2095-610X.S20210642

Volume 42 Issue 6

Jul. 2021

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Zhang-ping ZHOU, Xiao-qiong HE, Ling DUAN, Song TENG, Zhuo-xuan LIANG. Evaluation of Toxicology and Safety of Natural Active Compound Usenamine[J]. Journal of Kunming Medical University, 2021, 42(6): 22-28. doi: 10.12259/j.issn.2095-610X.S20210642

Citation:

Zhang-ping ZHOU, Xiao-qiong HE, Ling DUAN, Song TENG, Zhuo-xuan LIANG. Evaluation of Toxicology and Safety of Natural Active Compound Usenamine[J]. Journal of Kunming Medical University, 2021, 42(6): 22-28. doi: 10.12259/j.issn.2095-610X.S20210642

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Evaluation of Toxicology and Safety of Natural Active Compound Usenamine

doi: 10.12259/j.issn.2095-610X.S20210642

School of Public Health，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2021-03-16
Available Online: 2021-07-09
Publish Date: 2021-07-21

Abstract

Abstract

Objective To investigate the natural active compound Usenamine [C₁₈H₁₇NO₆, 6-acetyl-2-（1-amino-ethylene）-7, 9-dihydroxy-8, 9b-dimethyl-9bH- diphenylfuran -1, 3-dione] is safe to use. Methods SPF mice were selected for oral toxicity test, in vivo and in vitro chromosomal aberration test, bone marrow micronucleus test, sperm abnormality test and 30-day feeding test. Results Under the research conditions, the maximum tolerated dose （MTD） of the test substance for acute oral toxicity was more than 15000 mg/kg; both in vivo and in vitro chromosomal aberration tests were negative （P > 0.05）; bone marrow micronucleus test results were negative （P > 0.05） The result of sperm deformity test was negative （P > 0.05）; no obvious signs of poisoning were found in the 30-day feeding test, and all the indicators were normal. Conclusion Usenamine is safe and has no acute or subacute toxic effects, and genetic toxicity.
- Usenamine,
- Human normal lung epithelial cells BEAS-2B,
- Acute toxicity test,
- Chromosome aberration test

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