Signal Pathway Related Mechanism of Vein Graft Failure in Coronary Artery Bypass Grafting

Hu ZHANG; An-rui PENG; Jia-ji ZHONG; Bo HUANG

doi:10.12259/j.issn.2095-610X.S20210704

Volume 42 Issue 7

Jul. 2021

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Hu ZHANG, An-rui PENG, Jia-ji ZHONG, Bo HUANG. Signal Pathway Related Mechanism of Vein Graft Failure in Coronary Artery Bypass Grafting[J]. Journal of Kunming Medical University, 2021, 42(7): 20-24. doi: 10.12259/j.issn.2095-610X.S20210704

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Signal Pathway Related Mechanism of Vein Graft Failure in Coronary Artery Bypass Grafting

doi: 10.12259/j.issn.2095-610X.S20210704

1.
Dept. of Cardiavascular Surgery
2.
Dept. Of Operating Room，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-05-22
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

Objective To explore the signal pathway of vein graft failure in coronary artery bypass grafting. Methods 40 rabbits were randomly divided into two groups. Group A was sham operation group; Group B was model group in which rabbit model of CABG was established. The jugular vein in group A and the graft vein group B was removed 2 days and 2 weeks after the vein grafting, and pathological section was used to quantify lumen stenosis, immunohistochemistry was used to detect the phosphorylated p38, and the indexes were comared. Results Compared with group A, the degree of luminal stenosis of group B were significantly higher in 2 weeks after vein graft （P < 0.05）. The expression of p-p38 in vein graft tissue of group B were significantly higher than group A in 2 days and 2 weeks after vein grafting, p-p38 were significantly higher 2 days than 2 weeks after vein grafting in group B （P < 0.05）. Conclusion The mechanism of vein graft failure in CABG might be related to the p38 MAPK signal pathway.
- Coronary artery bypass graft（CABG）,
- Vein graft failure,
- Signal pathway,
- p38 MAPK,
- Rabbit

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References(14)

References

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