Anesthetic Effects and Mechanism of Hydromorphone Combined with Propofol on Colorectal Dilatation Model

Dan-ni ZHANG; Xia-guang DUAN; Chun-guang HAO; Xiao-jun ZHI; Hai-feng ZHU; Zai-qing HUANG

doi:10.12259/j.issn.2095-610X.S20210705

Volume 42 Issue 7

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(7): 25-30

Dan-ni ZHANG, Xia-guang DUAN, Chun-guang HAO, Xiao-jun ZHI, Hai-feng ZHU, Zai-qing HUANG. Anesthetic Effects and Mechanism of Hydromorphone Combined with Propofol on Colorectal Dilatation Model[J]. Journal of Kunming Medical University, 2021, 42(7): 25-30. doi: 10.12259/j.issn.2095-610X.S20210705

Citation:

Dan-ni ZHANG, Xia-guang DUAN, Chun-guang HAO, Xiao-jun ZHI, Hai-feng ZHU, Zai-qing HUANG. Anesthetic Effects and Mechanism of Hydromorphone Combined with Propofol on Colorectal Dilatation Model[J]. Journal of Kunming Medical University, 2021, 42(7): 25-30. doi: 10.12259/j.issn.2095-610X.S20210705

Citation:

Dan-ni ZHANG, Xia-guang DUAN, Chun-guang HAO, Xiao-jun ZHI, Hai-feng ZHU, Zai-qing HUANG. Anesthetic Effects and Mechanism of Hydromorphone Combined with Propofol on Colorectal Dilatation Model[J]. Journal of Kunming Medical University, 2021, 42(7): 25-30. doi: 10.12259/j.issn.2095-610X.S20210705

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Anesthetic Effects and Mechanism of Hydromorphone Combined with Propofol on Colorectal Dilatation Model

doi: 10.12259/j.issn.2095-610X.S20210705

Dept. of Anesthesiology，Inner Mongolia Baogang Hospital， Baotou Inner Mongolia 014010，China

Received Date: 2021-05-11
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

Objective To study the anesthetic effect of hydrocodone combined with propofol for painless colonoscopy and to investigate the mechanism of the analgesic effect produced by hydrocodone. Methods Clean grade male SD rats were randomly divided into four groups: normal group; propofol group; fentanyl combined with propofol group; hydromorphone combined with propofol group. After the model was anesthetized for 10 minutes, colorectal dilation was performed using a fully lubricated balloon for once per 5 min, each lasting 30 s. The abdominal wall withdrawal reflex （AWR3） scores of each group were recorded, and epinephrine and norepinephrine content were detected by ELISA. MAPK p38 expression changes were detected by western blot. Results （1） 10 minutes after abdominal administration of propofol, the AWR3 scores of the propofol group were significantly higher than those of the fentanyl combined with propofol group and the hydromorphone combined with propofol group （P < 0.0001, P < 0.0001）. The lowest AWR3 scores were reached 15 minutes after abdominal administration in all three groups. 20 minutes after abdominal administration, the AWR3 scores in the fentanyl combined with propofol group and the hydromorphone combined with propofol group were higher than those in the 10 and 15 minutes, but remained low. （2） The contents of epinephrine and norepinephrine in the fentanyl combined with propofol group and the hydromorphone combined with propofol group decreased significantly compared with those in the propofol group （epinephrine: P = 0.0023, P = 0.0002; norepinephrine: P < 0.0001, P < 0.0001）. （3） The p-p38/p38 ratio was significantly reduced in the fentanyl combined with propofol group and the hydromorphone combined with propofol group （P < 0.0001, P < 0.0001） compared with the propofol group rats. Conclusion Hydromorphone combined with propofol can effectively inhibit the phosphorylation of p38MAPK, thereby relieving pain.
- Painless enteroscopy,
- Hydromorphone,
- Propofol,
- p38MAPK

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References(35)

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