Association of Mismatch Repair Deficiency and Clinicopathological Parameters in Patients withLeft and Right-side Sporadic Colon Cancer

Lei LIANG; Xin PU; Wen-liang LI; Shu-min MA; Xiao-ting LIU; Xuan-yu MENG; Zhi-yong KOU; Jun YANG

doi:10.12259/j.issn.2095-610X.S20210706

Volume 42 Issue 7

Jul. 2021

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Lei LIANG, Xin PU, Wen-liang LI, Shu-min MA, Xiao-ting LIU, Xuan-yu MENG, Zhi-yong KOU, Jun YANG. Association of Mismatch Repair Deficiency and Clinicopathological Parameters in Patients withLeft and Right-side Sporadic Colon Cancer[J]. Journal of Kunming Medical University, 2021, 42(7): 31-42. doi: 10.12259/j.issn.2095-610X.S20210706

Citation:

Lei LIANG, Xin PU, Wen-liang LI, Shu-min MA, Xiao-ting LIU, Xuan-yu MENG, Zhi-yong KOU, Jun YANG. Association of Mismatch Repair Deficiency and Clinicopathological Parameters in Patients withLeft and Right-side Sporadic Colon Cancer[J]. Journal of Kunming Medical University, 2021, 42(7): 31-42. doi: 10.12259/j.issn.2095-610X.S20210706

Citation:

Lei LIANG, Xin PU, Wen-liang LI, Shu-min MA, Xiao-ting LIU, Xuan-yu MENG, Zhi-yong KOU, Jun YANG. Association of Mismatch Repair Deficiency and Clinicopathological Parameters in Patients withLeft and Right-side Sporadic Colon Cancer[J]. Journal of Kunming Medical University, 2021, 42(7): 31-42. doi: 10.12259/j.issn.2095-610X.S20210706

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Association of Mismatch Repair Deficiency and Clinicopathological Parameters in Patients withLeft and Right-side Sporadic Colon Cancer

doi: 10.12259/j.issn.2095-610X.S20210706

1.
Dept. of Oncology
2.
Dept. of Medical Record Statistics，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-04-11
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

Objective To analyze the correlation between mismatch repair-deficient （dMMR） and clinicopathological characteristics in left and right-side sporadic colorectal cancers. Methods The clinicopathological data of 1922 patients who were pathologically confirmed as adenocarcinoma from January 2014 to September 2019 in the First Affiliated Hospital of Kunming Medical University were collected, and the dMMR and gender, age, and body mass index （BMI）, ethnicity, blood type, preoperative CEA level, pathological type, tumor differentiation, tumor diameter, T stage, N stage, number of lymph nodes detected, distant metastasis, UICC stage, vascular invasion, perineural invasion were analyzed in sporadic left and right colorectal cancers. Results A total of 1922 cases of sporadic colorectal cancer met the inclusion criteria. Patients with sporadic right-side colon cancer accounted for 23.99% （461/1922）, and patients with sporadic left-side colorectal cancer accounted for 76.01% （1461/1 922）. The dMMR rate of all patients with sporadic colorectal cancer was 23.47% （451/1922）, the dMMR rate of sporadic right-side colon cancer was 38.83% （179/461）, and the dMMR rate of sporadic left-side colorectal cancer was 18.62% （272/1461）. Consistent with previous studies, the dMMR of all sporadic colorectal cancers in this study is more common in age < 62 years （OR = 1.551, P < 0.001）, right-side colon （OR = 2.603, p < 0.001）, tumor diameter≥4 cm （OR = 1.362, P = 0.009）, the degree of pathological differentiation is moderate-poorly differentiated （OR = 1.538, P = 0.046）, poorly differentiated （OR = 2.124, P = 0.013）and undifferentiated （OR = 1.850, P = 0.045））, UICC stages I～II （OR = 1.340, P = 0.014）, and patients without perineural invasion （OR = 1.407, P = 0.004）. In sporadic right colon cancer, dMMR is more common in patients younger than 62 years old （OR = 1.888, P = 0.001）, pT1～T2 （OR = 3.778, P = 0.000）and tumor diameter≥4 cm （OR = 1.856, p = 0.012）; in sporadic left-side colorectal cancer, dMMR is more common in age < 62 years （OR = 1.525, P = 0.002）, tumor diameter ≥4 cm （OR = 1.391, P = 0.016）, and no perineural invasion （OR = 1.454, P = 0.009）. Conclusions Regardless of the primary site of intestinal tumors, dMMR is more common in patients younger than 62 years and tumor diameter≥4 cm, while no perineural invasion and pT1～T2 are more common in sporadic left-side and right-side colorectal cancers, respectively.
- Sporadic colorectal cancer,
- Mismatch repair-deficient,
- Left-side colorectal cancer,
- Right-side colon cancer,
- Clinicopathological features

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