The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area

Ling NIU; Bo-yi LI; Jing-qiu MAO; Yan TANG; Rong MA; Fang LIU; Chen ZHANG; Zhu-jun HAN; Cui-juan MIAO; Xian ZHANG

doi:10.12259/j.issn.2095-610X.S20210711

Volume 42 Issue 7

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(7): 70-76

Ling NIU, Bo-yi LI, Jing-qiu MAO, Yan TANG, Rong MA, Fang LIU, Chen ZHANG, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area[J]. Journal of Kunming Medical University, 2021, 42(7): 70-76. doi: 10.12259/j.issn.2095-610X.S20210711

Citation:

Ling NIU, Bo-yi LI, Jing-qiu MAO, Yan TANG, Rong MA, Fang LIU, Chen ZHANG, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area[J]. Journal of Kunming Medical University, 2021, 42(7): 70-76. doi: 10.12259/j.issn.2095-610X.S20210711

Citation:

Ling NIU, Bo-yi LI, Jing-qiu MAO, Yan TANG, Rong MA, Fang LIU, Chen ZHANG, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area[J]. Journal of Kunming Medical University, 2021, 42(7): 70-76. doi: 10.12259/j.issn.2095-610X.S20210711

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The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area

doi: 10.12259/j.issn.2095-610X.S20210711

1.
Dept. of Endocrinology
2.
Dept. of Clinical Laboratory，First People’s Hospital of Kunmig，Kunming Yunnan 650011，China

Received Date: 2021-04-22
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

Objective To study the relationship between vitamin D receptor （VDR） gene polymorphism and type 2 diabetes mellitus （T2DM） with osteoporosis in Kunming area, and to explore the genetic susceptibility factors of T2DM with osteoporosis. Methods We selected 237 diabetic patients in the department of endocrinology of First People’ s hospital of Kunming from June 2017 to January 2019. （1） The patients were divided into T2DM without osteoporosis group （61 cases）, T2DM with osteopenia group （111 cases）, and T2DM with osteoporosis group （65 cases） by bone mineral density results. PCR - RFLP technique was used to detect VDR genotypes, we compared the differences between the three groups of patients in following indicators: VDR genotype and allele frequency, sex, age, duration of diabetes, blood pressure, height, weight, body mass index （BMI）, fasting plasma glucose （FPG）, glycosylated hemoglobin （HbA1c）, blood calcium, blood lipids, blood uric acid （UA）, the concentration of vitamin D, estrogen and testosterone levels, allergic C - reactive protein （Hs - CRP）, fibrinogen （FIB）, oral glucose tolerance （OGTT） -0 h, 2 h; 0 h, 2 h-insulin （INS） level and insulin resistance index （HOMA-IR）. （2） The differences in the bone mineral density was compared between different genotypes. （3） The VDR genotypes and the indicators with statistical differences between groups were analyzed by multivariate logistic regression. Results （1） VDR genotype was given priority to with a Bb, accounting for 77.6% in patients with T2DM in kunming area. （2） VDR genotype frequency and allele frequency differences between the three groups had no statistical significance （P > 0.05）. （3） There was no significant difference in BMD between the three genotypes of VDR （P > 0.05）（P > 0.05）. （4） Multivariate logistic regression analysis showed that age and smoking could enter the regression equation, but VDR genotype did not. Conclusions （1） The main VDR genotype of T2DM patients in Kunming was Bb （2） Age and smoking were independent risk factors of T2DM patients with osteoporosis in Kunming. VDR （BSMI） genotype was not associated with the genetic susceptibility of T2DM patients with osteoporosis in Kunming.
- Vitamin dreceptor gene polymorphism,
- Type 2 Diabetes Mellitus,
- Osteoporosis

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