Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD

Sheng-hao LI; Jie DING; Qing-qing WANG; Si-qi LIU; Li-juan HUA; Jin-yu DUAN; Bao-li BO; An-rui DU; Guo-ji CHANG; Jun-yi LI

doi:10.12259/j.issn.2095-610X.S20210712

Volume 42 Issue 7

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(7): 77-82

Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI. Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD[J]. Journal of Kunming Medical University, 2021, 42(7): 77-82. doi: 10.12259/j.issn.2095-610X.S20210712

Citation:

Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI. Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD[J]. Journal of Kunming Medical University, 2021, 42(7): 77-82. doi: 10.12259/j.issn.2095-610X.S20210712

Citation:

Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI. Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD[J]. Journal of Kunming Medical University, 2021, 42(7): 77-82. doi: 10.12259/j.issn.2095-610X.S20210712

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Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD

doi: 10.12259/j.issn.2095-610X.S20210712

1.
Dept. of Infectious Disease
2.
Dept. of Information，The Third People’s Hospital of Kunming，Kunming Yunnan 650041，Kunming Yunnan 650041，China

Received Date: 2021-04-25
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

Objective To investigate the influencing factors of liver injury in patients with chronic hepatitis B （CHB） and non-alcoholic fatty liver disease （NAFLD）. Methods The clinical data of 225 patients with CHB complicated with NAFLD admitted to the Third People’ s Hospital of Kunming from January 1^st, 2020 to December 30^th, 2020 were retrospectively analyzed. According to the liver function, they were divided into group A （120 cases, no liver injury or mild liver injury） and group B （105 cases, moderate or severe liver injury）. The basic information, metabolism biomarkers, routine blood, renal functions and etiology markers of hepatitis B were used to perform an unifactor analysis. To explore the influencing factors of moderate or severe liver injury, binary logistic regression analysis were further performed. Results 1. There were significant differences in gender[group A vs. group B （the same as following）: proportion of males = 76.67% vs. 87.62%], HBeAg （+/-） [（HBeAg positive） = 49.17% vs. 53.91%], CHOL[（4.89±0.95） mmol/L vs.（4.23±1.17） mmol/L], HDL-C[1.10 （0.94～1.28） mmol/L vs. 0.90 （0.53～1.18） mmol/L], LDL-C[3.03 （2.52～3.60）mmol/L vs. 2.70 （2.05～3.19） mmol/L], PLT[（202.47±60.79）*10⁹/L vs.（173.37±60.89）*10⁹/L], BUN[4.51 （3.83～5.41） mmol/L vs. 3.92 （3.37～5.02） mmol/L], UA[369.00 （314.00～421.00） μmol/L vs. 338.50 （292.00～397.25） μmol/L], Ln （HBV-DNA） [12.79 （7.82～17.31） IU/mL vs. 15.44 （12.64～17.76） IU/mL] between two groups （P < 0.05）. 2. Binary Logisitic regression analysis showed that PLT[OR （95%CI） = 0.993 （0.987～0.999）], BUN[OR （95%CI） = 0.726 （0.565～0.932）], UA[OR （95%CI） = 0.994 （0.990～0.998）], HDL-C[OR （95%CI） = 0.175 （0.060～0.510）] were protective factors, with 1 unit decrease of which, the probability of moderate and severe liver injury increased by 0.7%, 27.4%, 0.6% and 82.5%, respectively; ; and HBV-DNA [OR （95%CI）=1.138 （1.045～1.239）] was a risk factor, the probability of moderate to severe liver damage increased by 13.8% with 1 unit increase of Ln （HBV-DNA）. Conclusion HBV-DNA, HDL-C, BUN, UA and PLT are influencing factors for moderate or severe liver injury in CHB patients with NAFLD and a higher attention should to be paid.
- Chronic hepatitis B,
- Nonalcoholic fatty liverdisease,
- Liver injury,
- Influencing factors

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