Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020

Hai-lin HUANG; Xiao-juan LI; Jian-wen YIN; Hong-chao JIANG

doi:10.12259/j.issn.2095-610X.S20210713

Volume 42 Issue 7

Jul. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(7): 83-87

Hai-lin HUANG, Xiao-juan LI, Jian-wen YIN, Hong-chao JIANG. Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020[J]. Journal of Kunming Medical University, 2021, 42(7): 83-87. doi: 10.12259/j.issn.2095-610X.S20210713

Citation:

Hai-lin HUANG, Xiao-juan LI, Jian-wen YIN, Hong-chao JIANG. Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020[J]. Journal of Kunming Medical University, 2021, 42(7): 83-87. doi: 10.12259/j.issn.2095-610X.S20210713

Citation:

Hai-lin HUANG, Xiao-juan LI, Jian-wen YIN, Hong-chao JIANG. Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020[J]. Journal of Kunming Medical University, 2021, 42(7): 83-87. doi: 10.12259/j.issn.2095-610X.S20210713

PDF( 772 KB)

Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020

doi: 10.12259/j.issn.2095-610X.S20210713

1.
Dept. of Clinical Laboratory，Kunming Children’s Hospital，Kunming Yunnan，650228
2.
Center for Disease Control of Yunnan Province，Kunming Yunnan 650118，China

Received Date: 2021-05-09
Publish Date: 2021-07-25

Abstract

Abstract

Objective To study the distribution and drug sensitivity of Salmonella and Shigella in bacterial infectious diarrhea in children in Kunming and provide reliable basis for clinical rational drug use. Methods Salmonella and Shigella were cultured from the fecal samples of children with diarrhea in Kunming children’ s Hospital from 2017 to 2020. The pathogens were identified by Vitek compact, an automatic bacterial analyzer, and their drug sensitivity was determined. The agglutination serotyping was completed. Finally, the original data were analyzed and statistically analyzed by WHONET 5.6 software. Results A total of 226 strains of Shigella and Salmonella were isolated from 29674 specimen in our hospital from 2017 to 2020, including 75 strains of Shigella （33.2%）, 33 strains of Shigella flexneri （14.6%）, 42 strains of Shigella sonnei （18.6%）, and no Shigella dysentery and Shigella baumannii were detected. 151 strains （66.8%） of Salmonella were isolated and 5 serotypes were detected, including 106 strains （46.9%） of Salmonella typhimurium and 25 strains （11.1%） of Salmonella typhimurium. The main distribution of infectious diarrhea in Kunming children is from April to October, and the aggregation distribution is from May to October. 72.8% （110/151） of the population under 2 years old were susceptible to Salmonella infection. Diarrhea caused by Salmonella infection in children in Kunming is increasing year by year, and Salmonella typhimurium is the main Salmonella. This study showed that Shigella flexneri was the main Shigella species in 2017 and 2018, and changed to Shigella sonnei after 2019. In addition, amoxicillin/clavulanic acid （82%） was the first choice for children with infectious diarrhea caused by Salmonella in Kunming, while ceftazidime （97.6%） and amoxicillin/clavulanic acid （92.8%） were the first choice for Shigella sonnei. The sensitivity rates of Shigella flexneri to ceftazidime and cefepime were only 60% and 40%, which suggested that the susceptibility of Shigella serogroups to antibiotics is different. No imipenem resistance was found in Salmonella and Shigella. Conclusions Salmonella and Shigella are the main infectious diarrhea pathogen in children, while Salmonella shows an increasing trend year by year. The incidence of diarrhea is higher over 2 years old. Salmonella typhimurium is the main serotype. Amoxicillin/clavulanic acid is the first choice for empirical use. The drug resistance of Shigella serotypes to antibiotics is different. Therefore, it is necessary to strengthen the monitoring of pathogenic bacteria and drug resistance in feces of diarrhea children, It is necessary to strengthen the surveillance of pathogens and drug resistance of stools in children with diarrhea so as to provide clinicians with targeted anti infective treatment according to the results of drug sensitivity.
- Children,
- Infectious diarrhea,
- Pathogens,
- Drug resistance rate

FullText(HTML)

References(15)

References

[1]	赵江,刘志涛,张强,,等. 云南省2012年至2016年引起食源性腹泻的主要致病菌及其影响因素[J]. 昆明医科大学学报,2018,39(3):109-114. doi: 10.3969/j.issn.1003-4706.2018.03.022
[2]	赵江,邹颜秋硕,闵向东,等. 云南省食源性沙门菌血清分型及脉冲场凝胶电泳的指纹图谱[J]. 昆明医科大学学报,2018,39(2):30-33. doi: 10.3969/j.issn.1003-4706.2018.02.007
[3]	田云屏,邹颜秋硕,金莉,等. 云南省鼠伤寒沙门氏菌PFGE分子分型及耐药情况[J]. 昆明医科大学学报,2018,39(8):23-27. doi: 10.3969/j.issn.1003-4706.2018.08.006
[4]	尚红, 王毓三, 申子瑜, 等. 全国临床检验操作规程[M]. 第4版, 北京: 人民卫生出版社, 2015: 640.
[5]	周庭银, 倪语星, 胡继红, 等. 临床微生物检验标准化操作[M]. 第3版, 上海: 上海科学技术出版社, 2015: 367.
[6]	余建兴,赖圣杰,王鑫,等. 中国27省(市,自治区)2009-2013 年门诊腹泻病例诺如病毒流行特征分析[J]. 中华流行病学杂志,2015,36(3):199-204. doi: 10.3760/cma.j.issn.0254-6450.2015.03.003
[7]	Gorman R,Bloomfield S,Adley CC. A study of cross-contamination of food-borne pathogens in the domestic kitchen in the Republic of Ireland[J]. Int J Food Microbiol,2002,76(1-2):143-150. doi: 10.1016/S0168-1605(02)00028-4
[8]	于国慧,董方,刘锡清,等. 2009 年北京地区儿童感染性腹泻病原学及耐药性分析[J]. 中国小儿急救医学,2011,18(1):33-35.
[9]	魏仲秋,常海岭,李月芳,等. 2012−2014 年儿童非伤寒沙门菌肠道感染的临床流行病学特征及耐药模式[J]. 中华儿科杂志,2016,54(7):489-495. doi: 10.3760/cma.j.issn.0578-1310.2016.07.003
[10]	王萍萍,刘荻,金雪锋. 儿童细菌感染性腹泻临床特点及病原体分析[J]. 儿科药学杂志,2020,26(5):26-29.
[11]	肖勇,李泓,冯微宏,等. 腹泻病原在儿童中的感染流行特征及耐药性分析[J]. 中国卫生检验杂志,2020,30(24):2981-2983.
[12]	LSivapalasingam S ,Nelson J M,Joyce K,等. 1999-2002年美国国家抗菌素监测系统监测的志贺菌分离株耐药性的高流行度[J]. 抗生素与化疗,2006,50(1):49-54.
[13]	高庆双,高春燕,张晓玲,等. 腹泻患儿151株志贺菌分布特征与耐药性分析[J]. 现代预防医学,2016,43(1):60-61.
[14]	蒋鸿超,奎丽越,黄海林,等. 儿童感染的志贺菌I类整合子表达及其与产超广谱 β-内酰胺酶基因关系的研究[J]. 儿科药学杂志,2016,22(2):1-5.
[15]	Liang Z,Ke B,Deng X,et al. Serotypes,seasonal trends,and antibiotic resistance of non-typhoidal Salmonella,from human patients in Guangdong Province,China,2009—2012[J]. BMC Infectious Diseases,2015,15(1):53. doi: 10.1186/s12879-015-0784-4

Relative Articles(20)

Relative Articles

[1]	Wei HU, Jinnan LI, Wei YANG, Li SU, Zhuo YU, Zhisong CHEN. Interventional Treatment of Muscular Ventricular Septal Defect in Children. Journal of Kunming Medical University, 2024, 45(3): 48-53. doi: 10.12259/j.issn.2095-610X.S20240307
[2]	Feixue QIN, Juankun HE, Shi LIU, Bin WEN, Hong ZHU, Jing LI, Li GUI, Xiaoyan CAO. Study on the Distribution Characteristics of Pathogens in Hospitalized Diabetic Foot Patients and Its Correlation with Different Wagner Grades. Journal of Kunming Medical University, 2024, 46(): 1-7.
[3]	Xuelin ZHANG, Lu LIU, Yanzhi CHEN, Caijun ZHA, Yanli LI. The Distribution and Drug Resistance of Pathogenic Bacteria in Respiratory Tract Infections in Children from 2019 to 2022. Journal of Kunming Medical University, 2024, 45(1): 149-155. doi: 10.12259/j.issn.2095-610X.S20240125
[4]	Jie LI, Yuan HE, Chunyan WU, Bin SHAN, Rui ZHENG, Zhifu GUAN, Baojun REN, Chunxia SHI, Youquan ZHOU, Hanyu LIU, Mi ZHANG, Yanming KANG, Guibo SONG. Distribution and Drug Resistance Analysis of Bacteria in Sterile Body Fluids in Yunnan from 2017 to 2021. Journal of Kunming Medical University, 2023, 44(3): 61-67. doi: 10.12259/j.issn.2095-610X.S20230309
[5]	Shujin LI, Yanfei YANG, Min SU, Yu LING, Yanqiong RAO, Jihua CUI. Single Nucleotide Polymorphisms in Children with Attention Deficit Hyperactivity Disorder Comorbid Emotion Problems. Journal of Kunming Medical University, 2023, 44(4): 139-147. doi: 10.12259/j.issn.2095-610X.S20230420
[6]	Lu LI, Yunfen TIAN. Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children. Journal of Kunming Medical University, 2023, 44(7): 148-155. doi: 10.12259/j.issn.2095-610X.S20230708
[7]	Sixiang LIU, Yongkun HUANG, Mingying WANG, Hongwei HU, Min MA, Yu LING. Analysis of Intestinal Flora and Therapeutic Intervention in Children with Functional Constipation. Journal of Kunming Medical University, 2022, 43(3): 123-127. doi: 10.12259/j.issn.2095-610X.S20220309
[8]	Ying ZHANG, Hong GAO, Cuixiang ZHANG, Zeying CHEN, Hongqun ZOU, Liqiong LI, Jupin YANG, Yuexin HU. Helicobacter Pylori Infection in Children and its Correlation with Iron Deficiency Anemia. Journal of Kunming Medical University, 2022, 43(4): 103-106. doi: 10.12259/j.issn.2095-610X.S20220418
[9]	Shu-lan SHI, Xi-ting DAI, Guang-zhou ZHAO, Xiao Juan LI, Rong-jie LI, Ming-biao MA. Application of 16SrRNA Gene Detection in the Early Diagnosis of Bacterial Meningitis in Children. Journal of Kunming Medical University, 2021, 42(5): 120-125. doi: 10.12259/j.issn.2095-610X.S20210522
[10]	Zheng Zhi Rong , Shao Rui Fei , Zhao Shi Ming , Zhang Yi Xin , Chen Guo Bing . . Journal of Kunming Medical University, 2020, 41(05): 91-95.
[11]	Fu Yan , Li Xin Yi , Yuan Yong , Wang Wei Hua . . Journal of Kunming Medical University, 2019, 40(06): 121-124.
[12]	Zhao Lin , Cao Li Yun , Lv Gao Jie , Li Ming Pan . Etiological Analysis of Community-acquired Lower Respiratory Tract Infection in Children in Kunming. Journal of Kunming Medical University, 2018, 39(05): 61-65.
[13]	Yang Jun Jun , Hu Xi Chi , Yan Zi He . . Journal of Kunming Medical University, 2017, 38(03): 119-122.
[14]	Zhao Xiao Li . . Journal of Kunming Medical University,
[15]	He Cheng Lu . . Journal of Kunming Medical University,
[16]	Qi Yan Wei . 云南省HIV/AIDS患者下呼吸道感染病原菌分布及耐药分析. Journal of Kunming Medical University,
[17]	Sheng Xiao Cui . . Journal of Kunming Medical University,
[18]	Li Xiu Yun . . Journal of Kunming Medical University,
[19]	He Li Yun . . Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,