Correlation between Serum 25-hydroxyvitamin D and Peripheral Neuropathy in Type 2 Diabetes

Xiao-rui YANG; Qian XIANG; Ya QIU; Yan LUAN; Xian ZHANG; Yan GUO

doi:10.12259/j.issn.2095-610X.S20210714

Volume 42 Issue 7

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(7): 88-93

Xiao-rui YANG, Qian XIANG, Ya QIU, Yan LUAN, Xian ZHANG, Yan GUO. Correlation between Serum 25-hydroxyvitamin D and Peripheral Neuropathy in Type 2 Diabetes[J]. Journal of Kunming Medical University, 2021, 42(7): 88-93. doi: 10.12259/j.issn.2095-610X.S20210714

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Xiao-rui YANG, Qian XIANG, Ya QIU, Yan LUAN, Xian ZHANG, Yan GUO. Correlation between Serum 25-hydroxyvitamin D and Peripheral Neuropathy in Type 2 Diabetes[J]. Journal of Kunming Medical University, 2021, 42(7): 88-93. doi: 10.12259/j.issn.2095-610X.S20210714

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Correlation between Serum 25-hydroxyvitamin D and Peripheral Neuropathy in Type 2 Diabetes

doi: 10.12259/j.issn.2095-610X.S20210714

1.
Dept. of Endocrine
2.
Dept. of Neuroelectrophysiology
3.
Dept. of Scientific Research and Education，The Fifth Affiliated Hospital of Kunming Medical University/The Central Hospital of Honghe Prefecture，Gejiu Yunnan 661000，China

Received Date: 2021-04-17
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

Objective To investigate the correlation between 25 （OH） D level and the occurrence of DPN. Methods A total of 138 patients with type 2 diabetes mellitus （T2DM） were selected as the study subjects. According to the clinical symptoms and neurogram results, there were 47 patients in the SDM group. And 91 patients in the DPN group were divided into 54 patients in the non-clinical group （DPN1 group） and 37 patients in the clinically symptomatic group （DPN2 group）. The gender, age, treatment season, diabetes mellitus （DM） course, smoking history, SBP, DBP, BMI, 25 （OH） D, Ca, P, FPG, 2 hPG, HbA1c, FC, TC, TG, HDL-C, LDL-C and other indicators of all patients were collected. The group differences of the above indicators were compared, and the correlation between serum 25 （OH） D and the above indicators was analyzed. The occurrence risk factors of DPN were analyzed by binary Logistic regression. Results （1） The median serum 25 （OH） D in hospitalized T2DM patients was 16.25 （12.88, 19.90） ng/ml, and 97.10% of the patients were deficient （76.09%） and inadequate （21.01%） in 25 （OH） D. The proportion of serum 25 （OH） D deficiency in SDM group, DPN1 group and DPN2 group was 68.09%, 77.78% and 83.78%, 25 （OH） D inadequacy was 25.53%, 20.37% and 16.22%, and 25 （OH） D adequacy was 6.38%, 1.85%, and 0.00%, respectively. The difference between the groups was not statistically significant （P > 0.05）. （2） Binary Logistic regression analysis showed that 25 （OH） D was a protective factor in the occurrence of DPN （OR = 0.238, 95%CI 0.074-0.764, P < 0.05）. Conclusions （1） 25 （OH） D deficiency and inadequacy are common in hospitalized T2DM patients. （2） Serum 25 （OH） D may be a protective factor for the occurrence of DPN.
- Type 2 diabetes mellitus,
- Diabetic peripheral neuropathy,
- 25-hydro xyvitamin D

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References(21)

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