Research Progress of Orphan Receptor GPR88 in Related Diseases

Di ZENG; Han-rui SHAO; Ying-ying ZOU; Yong-hua RUAN

doi:10.12259/j.issn.2095-610X.S20210723

Volume 42 Issue 7

Jul. 2021

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Di ZENG, Han-rui SHAO, Ying-ying ZOU, Yong-hua RUAN. Research Progress of Orphan Receptor GPR88 in Related Diseases[J]. Journal of Kunming Medical University, 2021, 42(7): 137-142. doi: 10.12259/j.issn.2095-610X.S20210723

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Di ZENG, Han-rui SHAO, Ying-ying ZOU, Yong-hua RUAN. Research Progress of Orphan Receptor GPR88 in Related Diseases[J]. Journal of Kunming Medical University, 2021, 42(7): 137-142. doi: 10.12259/j.issn.2095-610X.S20210723

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Research Progress of Orphan Receptor GPR88 in Related Diseases

doi: 10.12259/j.issn.2095-610X.S20210723

Dept. of Pathology and Pathophysiology，School of Basic Medicines，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2021-04-18
Available Online: 2021-07-19
Publish Date: 2021-07-21

Abstract

Abstract

GPR88 is an orphan receptor of the Class A rhodopsin family, belonging to the G protein-coupled receptors （GPCRs） family. Existing studies have shown that it is involved in the occurrence and development of a variety of diseases, and at the same time as a potential therapeutic target has aroused widespread interest of researchers. This article reviews the recent research progress of GPR88 receptors in hypertension, alcohol use disorder, anxiety, schizophrenia, movement disorders and other related diseases and agonists, and aims to provide a deeper level of research on GPR88protein Theoretical basis.
- G protein coupled receptor 88 （GPR88）,
- GPR88 agonist,
- Hypertension,
- Alcohol use disorders,
- Anxiety,
- Schizophrenia,
- Movement disorders

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References(46)

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