Hypoglycemic Effects of <i>Swertia Punicea</i> Hemsl on Alloxan-Induced Diabetic Mice

Shao-long KANG; Hui-ling WANG; Dong-mei LI; Yong LAI; Huai XIAO

doi:10.12259/j.issn.2095-610X.S20210803

Volume 42 Issue 8

Aug. 2021

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Shao-long KANG, Hui-ling WANG, Dong-mei LI, Yong LAI, Huai XIAO. Hypoglycemic Effects of Swertia Punicea Hemsl on Alloxan-Induced Diabetic Mice[J]. Journal of Kunming Medical University, 2021, 42(8): 11-16. doi: 10.12259/j.issn.2095-610X.S20210803

Citation:

Shao-long KANG, Hui-ling WANG, Dong-mei LI, Yong LAI, Huai XIAO. Hypoglycemic Effects of Swertia Punicea Hemsl on Alloxan-Induced Diabetic Mice[J]. Journal of Kunming Medical University, 2021, 42(8): 11-16. doi: 10.12259/j.issn.2095-610X.S20210803

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Hypoglycemic Effects of Swertia Punicea Hemsl on Alloxan-Induced Diabetic Mice

doi: 10.12259/j.issn.2095-610X.S20210803

1.
Dept. Clinical Pharmacology，Lincang people’s Hospital，Lincang Yunnan 677099
2.
Key Laboratory of Entomological Biopharmaceutical R&D， Dali University，Dali Yunnan 671000，China

Received Date: 2021-06-11
Publish Date: 2021-08-25

Abstract

Abstract

Objective To screen the hypoglycemic activity of 4 extracts of Swertia Punicea Hemsl. Methods The ethanol extract of Swertia Punicea Hemsl was extracted by ethanol extraction, and the extracts were successively extracted with petroleum ether, chloroform, ethyl acetate and n-butanol to obtain 4 parts: chloroform, Ethyl Acetate, n-butanol and water, the 4 extracts were screened for hypoglycemic activity in Type I diabetic mice induced by alloxan. The diet and water of each group were measured daily starting from day 3; weight of all mice were measured every 2 days and blood glucose of each group was measured on the 7th and 14th day. Results The body weight of the diabetic mice was significantly increased （P < 0.05）, and the food intake, amount of drinking water, blood glucose were significantly decreased （ P < 0.05） in the diabetic mice fed with the water-soluble fraction and ethyl acetate extract fraction of Swertia Punicea Hemsl. Conclusion The water-soluble fraction and ethyl acetate extract fraction of Swertia Punicea Hemsl could significantly improve the symptoms of polydipsia, polyphagia, polyuria and weight loss in type I diabetic mice induced by alloxan, and significantly reduce the blood glucose of diabetic mice, showing a strong hypoglycemic activity.
- Swertia punicea hemsl,
- Alloxan-induced diabetic mice,
- Hypoglycemic activity

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References(22)

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