Correlation Between Serum Soluble ST2 and Cardiac Remodeling in Patients with Heart Failure with Reduced Ejection Fraction

Wei-wen WANG; De-xia LI; Jie ZHANG; Lin LI

doi:10.12259/j.issn.2095-610X.S20210813

Volume 42 Issue 8

Aug. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(8): 71-77

Wei-wen WANG, De-xia LI, Jie ZHANG, Lin LI. Correlation Between Serum Soluble ST2 and Cardiac Remodeling in Patients with Heart Failure with Reduced Ejection Fraction[J]. Journal of Kunming Medical University, 2021, 42(8): 71-77. doi: 10.12259/j.issn.2095-610X.S20210813

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Wei-wen WANG, De-xia LI, Jie ZHANG, Lin LI. Correlation Between Serum Soluble ST2 and Cardiac Remodeling in Patients with Heart Failure with Reduced Ejection Fraction[J]. Journal of Kunming Medical University, 2021, 42(8): 71-77. doi: 10.12259/j.issn.2095-610X.S20210813

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Correlation Between Serum Soluble ST2 and Cardiac Remodeling in Patients with Heart Failure with Reduced Ejection Fraction

doi: 10.12259/j.issn.2095-610X.S20210813

1.
Dept. of Cardiology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of General Practice，People’s Hospital of Lijiang，Lijiang Yunnan 674100，China

Received Date: 2021-06-26
Publish Date: 2021-08-25

Abstract

Abstract

Objective To investigate the correlation between serum soluble oncogenic inhibitor 2 （sST2） level and cardiac function and remodeling in patients with heart failure （HFrEF） with reduced ejection fraction. Methods A total of 110 patients with HFrEF admitted to the Department of Cardiology, the First Affiliated Hospital of Kunming Medical University from July 2019 to September 2020 were enrolled. Serum sST2 levels were detected by immunofluorescence dry quantitative method, and parameters reflecting cardiac function and structure in echocardiography were collected. Left ventricular ejection fraction （LVEF）, interventricular septal thickness, left atrial inner diameter, right atrial length diameter, left ventricular posterior wall, right ventricular length diameter, left ventricular end-diastolic volume （LVEDV）, left ventricular end-systolic volume （LVESV） and other indicators were calculated. LVEDVI and LVESVI were calculated. The subjects were divided into low level group （sST2 < 20.0 ng/mL, n = 55） and high level group （sST2 ≥20.0 ng/mL, n = 55） according to the median serum sST2 level of 20.0 ng/mL. The correlation between serum sST2 level and cardiac function and cardiac remodeling indexes was analyzed. Results Among 110 HFrEF patients, the median serum sST2 level was 20.0 ng/mL. Patients with higher serum sST2 level were more likely to have chronic kidney disease and thyroid dysfunction than patients with lower serum sST2 level. Patients with higher serum sST2 level had higher D-dimer, B-type natriuretic peptide, creatinine, uric acid, aspartate aminotransferase level, and larger right atrial diameter, higher pulmonary artery systolic pressure than patients with lower serum sST2 level （P < 0.05）. Serum sST2 level was positively correlated with pulmonary artery systolic pressure （ r = 0.284, P = 0.003） and right atrial diameter （r = 0.356, P = 0.000）. Conclusion In HFrEF patients, serum sST2 level was positively correlated with pulmonary artery systolic pressure and right atrial diameter. The higher sST2 level was, the larger right atrial diameter and pulmonary artery systolic pressure were. In other words, serum sST2 level in patients with HFrEF is correlated with right heart function. Serum sST2 may play an important role in cardiac remodeling in patients with HFrEF.
- Heart failure with reduced ejection fraction,
- Soluble ST2,
- Heart function,
- Cardiac remodeling

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References(18)

References

[1]	中华医学会心血管病学分会心力衰竭学组;中国医师协会心力衰竭专业委员会;中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2018[J]. 中华心血管病杂志,2018,46(10):760-789. doi: 10.3760/cma.j.issn.0253-3758.2018.10.004
[2]	卢景晶,李秀,刘巍. 心肌细胞外基质重构与心力衰竭[J]. 国际心血管病杂志,2015,42(4):229-230. doi: 10.3969/j.issn.1673-6583.2015.04.005
[3]	Emdin M,Aimo A,Vergaro G,et al. sST2 Predicts outcome in chronic heart failure beyond NT-proBNP and high-sensitivity troponin T[J]. J Am Coll Cardiol,2018,72(19):2309-2320. doi: 10.1016/j.jacc.2018.08.2165
[4]	Pascual Figal D A,Bayes Genis A,Asensio-Lopez MC,et al. The interleukin-1 axis and risk of death in patients with acutely decompensated heart failure[J]. J Am Coll Cardiol,2019,73(9):1016-1025.
[5]	Weinberg E O,Shimpo M,Hurwitz S,et al. Identification of serum soluble ST2 receptor as a novel heart failure biomarker[J]. Circulation,2003,107(5):721-726. doi: 10.1161/01.CIR.0000047274.66749.FE
[6]	Pascual Figal D A,Januzzi J L. The biology of ST2:The international ST2 consensus panel[J]. Am J Cardiol,2015,115(7 Suppl):3B-7B.
[7]	Bayes Genis A,Zamora E,de Antonio M,et al. Soluble ST2 serum concentration and renal function in heart failure[J]. J Card Fail,2013,19(11):768-775. doi: 10.1016/j.cardfail.2013.09.005
[8]	Parikh R H,Seliger S L,Christenson R,et al. Soluble ST2 for prediction of heart failure and cardiovascular death in an elderly,community-dwelling population[J]. J Am Heart Assoc,2016,5(8):1-11.
[9]	Roth G A,Zimmermann M,Lubsczyk B A,et al. Up-regulation of interleukin 33 and soluble ST2 serum levels in liver failure[J]. J Surg Res,2010,163(2):e79-e83. doi: 10.1016/j.jss.2010.04.004
[10]	Sun Z,Chang B,Huang A,et al. Plasma levels of soluble ST2,but not IL-33,correlate with the severity of alcoholic liver disease[J]. J Cell Mol Med,2019,23(2):887-897. doi: 10.1111/jcmm.13990
[11]	Bergis D,Kassis V,Ranglack A,et al. High serum levels of the interleukin-33 receptor soluble ST2 as a negative prognostic factor in hepatocellular carcinoma[J]. Transl Oncol,2013,6(3):311-318. doi: 10.1593/tlo.12418
[12]	段洪强,闫鹏,祁娜. 血清GDF-15、sST2与慢性心力衰竭患者心功能的相关性分析及对预后的评估[J]. 分子诊断与治疗杂志,2021,13(3):453-456. doi: 10.3969/j.issn.1674-6929.2021.03.030
[13]	雷媛媛, 邓洁. 扩张型心肌病患者sST2和Gal-3的水平及其与心肌纤维化关系的研究[D]. 昆明: 昆明医科大学硕士研究生论文, 2020.
[14]	李玉,段敬柱,王崇全. 扩张型心肌病患者血清可溶性ST2与心室重构的相关性研究[J]. 解放军医药杂志,2018,30(7):39-42. doi: 10.3969/j.issn.2095-140X.2018.07.009
[15]	Ojji DB, Lecour S, Adeyemi OM, et al. Soluble ST2 correlates with some indicators of right ventricular function in hypertensive heart failure[J]. Vasc Health Risk Manag, 2017, 13: 311-316.（无明确期号）. Ojji D B,Lecour S,Adeyemi O M,et al. Soluble ST2 correlates with some indicators of right ventricular function in hypertensive heart failure[J]. Vasc Health Risk Manag,2017,13:311-316.
[16]	Nair N, Gongora E. Correlations of GDF-15 with sST2, MMPs, and worsening functional capacity in idiopathic dilated cardiomyopathy: Can we gain new insights into the pathophysiology? [J]. J Circ Biomark, 2018, 7: 1-8.（无明确期号）. Nair N,Gongora E. Correlations of GDF-15 with sST2,MMPs,and worsening functional capacity in idiopathic dilated cardiomyopathy:Can we gain new insights into the pathophysiology?[J]. J Circ Biomark,2018,7:1-8.
[17]	Kingery J R,Goyal P,Hosalli R,et al. Human immunodeficiency virus-associated myocardial diastolic dysfunction and soluble ST2 concentration in Tanzanian adults:A cross-sectional study[J]. J Infect Dis,2021,223(1):83-93. doi: 10.1093/infdis/jiaa328
[18]	Lupu S, Agoston-Coldea L. Soluble ST2 in ventricular dysfunction[J]. Adv Clin Chem, 2015, 69: 139-159.（无明确期号）. Lupu S,Agoston-Coldea L. Soluble ST2 in ventricular dysfunction[J]. Adv Clin Chem,2015,69:139-159.

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