Drug Resistance of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in Children with Bloodstream Infection from 2017 to 2020

Hai-lin HUANG; Hong-chao JIANG; Xiao-juan LI

doi:10.12259/j.issn.2095-610X.S20210817

Volume 42 Issue 8

Aug. 2021

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Hai-lin HUANG, Hong-chao JIANG, Xiao-juan LI. Drug Resistance of Escherichia coli and Klebsiella pneumoniae in Children with Bloodstream Infection from 2017 to 2020[J]. Journal of Kunming Medical University, 2021, 42(8): 95-100. doi: 10.12259/j.issn.2095-610X.S20210817

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Hai-lin HUANG, Hong-chao JIANG, Xiao-juan LI. Drug Resistance of Escherichia coli and Klebsiella pneumoniae in Children with Bloodstream Infection from 2017 to 2020[J]. Journal of Kunming Medical University, 2021, 42(8): 95-100. doi: 10.12259/j.issn.2095-610X.S20210817

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Drug Resistance of Escherichia coli and Klebsiella pneumoniae in Children with Bloodstream Infection from 2017 to 2020

doi: 10.12259/j.issn.2095-610X.S20210817

Dept. of Clinical Laboratory ，Kunming Children’s Hospital，Kunming Yunnan 650228，China

Received Date: 2021-06-17
Available Online: 2021-08-04
Publish Date: 2021-08-04

Abstract

Abstract

Objective To analyze the drug resistance of Escherichia coli and Klebsiella pneumoniae causing bloodstream infection in our hospital from 2017 to 2020, so as to provide reference for clinical treatment of children with bloodstream infection. Methods The blood culture results of outpatients and inpatient children with clinical diagnosis of bacteremia in our hospital from January, 2017 to April, 2020 were collected, and data were analyzed by WHONET 5.6 software. Results A total of 193 strains of Escherichia coli were isolated from blood culture positive samples, including 100 strains （51.8%） producing extended spectrum β-lactamases （ESBLs）, 8 strains （3.3%） of carbapenem resistant Escherichia coli （CR-ECO）. There were 46 strains of Klebsiella pneumoniae, including 18 strains （39.1%） producing extended spectrum beta lactamases （ESBLs）, and 14 strains （30.4%） of carbapenem resistant Klebsiella pneumoniae （CR-KPN）. The resistance rate of ESBLs producing strains of Escherichia coli and Klebsiella pneumoniae was higher than that of non-ESBLs producing strains. The resistance rate of CR-ECO to aztreonam was 85.7%, and the resistance rates to ciprofloxacin, levofloxacin and cotrimoxazole were 100%; The resistance rate of CR-KPN to aztreonam was 61.1%, the resistance rates to ciprofloxacin, levofloxacin was 44.4%, and the resistance rate to cotrimoxazole was 5.6%. The MIC value of imipenem in 12 CR- KPN strains were greater than 16 µg/mL, accounting for 85.7% （12/14）. The MIC value of imipenem in 7 CR-ECO strains were greater than 16 µg/mL, accounting for 87.5% （7/8）. The highest distribution of isolated strains in clinical departments was in neonatology department, followed by hematology tumor and intensive care unit; most of the newborns aged < 28 days, followed by > 28 days to 1 year old. Conclusion The neonatal ward, hematological oncology and intensive care unit of our hospital have higher prevelance of bloodstream infection of multiple drug resistant Escherichia coli and Klebsiella pneumoniae. These infections are difficult to treat, which is an issure we should address. It is particularly important to control infection effectively and reduce the emergence of drug-resistant strains.
- Bloodstream infection,
- Escherichia coli,
- Klebsiella pneumoniae,
- Drug resistance

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References(14)

References

[1]	刘周,徐晨,姚杰,等. 血流感染肠杆菌科细菌临床分布与耐药性研究[J]. 中华医院感染学杂志,2015,25(24):5559-5561.
[2]	卯建,任玉吉,单斌,等. 2012年至2014年中国云南地区血流感染革兰阴性杆菌的构成及耐药性[J]. 昆明医科大学学报,2016,37(12):24-28.
[3]	经晓杰,陈正辉引,王应忠剐,等. 急诊重症监护病房革兰阴性杆菌感染分布及耐药性[J]. 昆明医科大学学报,2015,36(5):69-73.
[4]	尚红, 王毓三, 申子瑜. 全国临床检验操作规程(第四版)[M]. 北京: 人民卫生出版社, 2015: 175-177.
[5]	刘冰,董方,宋文琪,等. 儿科血培养增加厌氧菌培养瓶应用价值[J]. 中华传染病杂志,2018,36(6):373-376. doi: 10.3760/cma.j.issn.1000-6680.2018.06.015
[6]	刘冲,苏建荣,闫东辉,等. 重症监护病房多重耐药鲍曼不动杆菌感染及耐药性分析[J]. 中华检验医学杂志,2015,38(1):55-58. doi: 10.3760/cma.j.issn.1009-9158.2015.01.014
[7]	景春梅, 许红梅, 赵瑞秋, 等. 2016—2018 年 11 所医院儿童血培养分离菌的耐药性分析[J]中国感染与化疗杂志, 2021, 21(1): 78-87.
[8]	张有江,李心雨,罗燕萍,等. 2007-2010年引起血流感染肠杆菌科细菌分布及药物敏感性分析[J]. 中华医院感染学杂志,2011,21(22):4812-4814.
[9]	郭金珍,姜泓,宋文萍,等. 陕西省住院新生儿出生胎龄 < 34 周早产儿院内感染败血症多中心流行病学调查[J]. 中华实用儿科临床杂志,2019,34(23):1774-1777. doi: 10.3760/cma.j.issn.2095-428X.2019.23.004
[10]	杨启文,吴安华,胡必杰,等. 临床重要耐药菌感染传播防控策略专家共识[J]. 中国感染控制杂志,2021,20(1):5-10.
[11]	D'Angelo R G,Johnson J K,Bork J T,et al. Treatment options for extended-spectrum beta-lactamase (ESBL) and AmpC-producing bacteria[J]. Expert Opin Pharmacother,2016,17(7):953-967. doi: 10.1517/14656566.2016.1154538
[12]	胡付品,郭燕,朱德妹,等. 2019 年 CHINET 三级医院细菌耐药监测[J]. 中国感染与化疗杂志,2020,20(3):241-243.
[13]	张琴,许健,宋培培,等. 儿童患者检出耐碳青霉烯类抗菌药物肠杆菌科细菌分布特征及耐药性分析[J]. 中国抗生素杂志,2020,45(12):1273-1278. doi: 10.3969/j.issn.1001-8689.2020.12.012
[14]	郝敏,秦晓华. 亚胺培南联合8种抗菌药物对产KPC-2 酶肺炎克雷伯菌的体外联合药敏试验[J]. 中国感染与化疗杂志,2019,19(4):411.

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