Expression and Significance of microRNA-21 and EGFR in Non-small Cell Lung Cancer

Ying-xia WANG; Qin HE; Guo-fang WANG; Xuan ZHANG

doi:10.12259/j.issn.2095-610X.S20210818

Volume 42 Issue 8

Aug. 2021

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Ying-xia WANG, Qin HE, Guo-fang WANG, Xuan ZHANG. Expression and Significance of microRNA-21 and EGFR in Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2021, 42(8): 101-105. doi: 10.12259/j.issn.2095-610X.S20210818

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Ying-xia WANG, Qin HE, Guo-fang WANG, Xuan ZHANG. Expression and Significance of microRNA-21 and EGFR in Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2021, 42(8): 101-105. doi: 10.12259/j.issn.2095-610X.S20210818

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Expression and Significance of microRNA-21 and EGFR in Non-small Cell Lung Cancer

doi: 10.12259/j.issn.2095-610X.S20210818

1.
Dept. of Pathology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2021-06-26
Available Online: 2021-08-04
Publish Date: 2021-08-04

Abstract

Abstract

Objective To explore the expression and significance of microRNA-21 and its regulatory gene EGFR in non-small cell lung cancer, lung adenocarcinoma and squamous cell carcinoma. Methods Lung tissue samples of 30 patients with pathologically confirmed non-small cell lung cancer from October 2020 to December 2020 in The 1st Affiliated Hospital of Kunming Medical University were taken as the research objects, including 24 cases of lung adenocarcinoma and 6 cases of lung squamous cell carcinoma, and the lung tissue adjacent to cancer was taken as the control. The expression of microRNA-21 was detected by real-time quantitative PCR, and the protein expression and localization of EGFR were detected by immunohistochemistry. Results The expression levels of microRNA-21 and EGFR in lung tissue adjacent to cancer were lower. Compared with lung tissue adjacent to cancer, the expression levels of microRNA-21 and EGFR in lung adenocarcinoma and lung squamous cell carcinoma were significantly increased （P < 0.01）; compared with lung adenocarcinoma, the expression levels of microRNA-21 and EGFR in lung squamous cell carcinoma were significantly increased （P < 0.05）. Conclusion MicroRNA-21 and its regulatory gene EGFR are highly expressed in NSCLC lung adenocarcinoma and squamous cell carcinoma, and the expression trend is consistent, which can be used to predict the progress and prognosis of NSCLC.
- Non small cell lung cancer,
- MicroRNA-21,
- Lung adenocarcinoma,
- Lung squamous cell carcinoma,
- EGFR

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References(15)

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