Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin

Qiong ZHOU; Bao-kun PENG; Xiao-chun WENG; Zhen JU; Nuo-pi-chu SUN; Zhe TANG

doi:10.12259/j.issn.2095-610X.S20210819

Volume 42 Issue 8

Aug. 2021

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Qiong ZHOU, Bao-kun PENG, Xiao-chun WENG, Zhen JU, Nuo-pi-chu SUN, Zhe TANG. Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin[J]. Journal of Kunming Medical University, 2021, 42(8): 106-110. doi: 10.12259/j.issn.2095-610X.S20210819

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Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin

doi: 10.12259/j.issn.2095-610X.S20210819

1.
Dept. of Endocrinology，Yan’an Hospital Affilliated to Kunming Medical University，Kunming Yunnan，650051
2.
Dept. of General Internal Medicine，People’s Hospital of Deqin，Deqin Yunnan，674500，China

Received Date: 2021-06-07
Available Online: 2021-08-04
Publish Date: 2021-08-04

Abstract

Abstract

Objective To investigate the clinical characteristics of newly diagnosed type 2 diabetes mellitus （T2DM） patients among Tibetans in Deqin, analyze the influencing factors of HbA1c, and explore the correlation between HbA1c and hemoglobin （Hb） in Tibetan population at high altitude. Methods Clinical data of 120 tibetan patients with medical examination or receiving diagnosis and treatment in People’ s Hospital of Deqinfrom May 2018 to June 2020 were collected, and they were divided into three groups according to blood glucose level: newly diagnosed type 2 diabetes group, pre-diabetes group and normal glucose tolerance group. General data and laboratory indexes among the three groups were compared. According to hemoglobin level, the subjects were divided into high hemoglobin group and normal hemoglobin group. Fasting plasma glucose （FPG）, two-hour postprandial plasma glucose （2 hPG） and glycosylated hemoglobin （HbA1c） levels between the two groups were compared. The relationship between HbA1c and FPG, 2 hPG and Hb was analyzed by multiple linear regression. Results Comparedwith the normal glucose tolerance group, the diabetes group had higher body mass index （BMI）, triglyceride （TG）, cholesterol （TC）, low density lipoprotein （LDL） and fatty liver ratio （P < 0.05）. There were no significant differences in gender, age, hypertension, high density lipoprotein （HDL）, uric acid （UA）, red blood cell （RBC） and Hb among the three groups. There was no significant difference in FPG, 2 hPG and HbA1c between the high hemoglobin group and the normal hemoglobin group （P > 0.05）. Multiple linear regression analysis showed that both FPG and 2 hPG affected HbA1c, but Hb did not. The regression equation was y = 2.422 + 0.217 × FPG + 0.227 × 2 hPG （R² = 0.73, P < 0.05）. Conclusion BMI, TG, TC and fatty liver in patients with newly diagnosed type 2 diabetes mellitus in Deqin Tibetan nationality is higher, which is a clue for early recognition of diabetes. The main influencing factors of HbA1c were FPG and 2 hPG. Hb was not the influencing factor of HbA1c.
- Type 2 Diabetes,
- Plateau,
- Tibetan,
- Glycosylated hemoglobin

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