Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin

Qiong ZHOU; Bao-kun PENG; Xiao-chun WENG; Zhen JU; Nuo-pi-chu SUN; Zhe TANG

doi:10.12259/j.issn.2095-610X.S20210819

Volume 42 Issue 8

Aug. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(8): 106-110

Qiong ZHOU, Bao-kun PENG, Xiao-chun WENG, Zhen JU, Nuo-pi-chu SUN, Zhe TANG. Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin[J]. Journal of Kunming Medical University, 2021, 42(8): 106-110. doi: 10.12259/j.issn.2095-610X.S20210819

Citation:

Qiong ZHOU, Bao-kun PENG, Xiao-chun WENG, Zhen JU, Nuo-pi-chu SUN, Zhe TANG. Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin[J]. Journal of Kunming Medical University, 2021, 42(8): 106-110. doi: 10.12259/j.issn.2095-610X.S20210819

Citation:

Qiong ZHOU, Bao-kun PENG, Xiao-chun WENG, Zhen JU, Nuo-pi-chu SUN, Zhe TANG. Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin[J]. Journal of Kunming Medical University, 2021, 42(8): 106-110. doi: 10.12259/j.issn.2095-610X.S20210819

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Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin

doi: 10.12259/j.issn.2095-610X.S20210819

1.
Dept. of Endocrinology，Yan’an Hospital Affilliated to Kunming Medical University，Kunming Yunnan，650051
2.
Dept. of General Internal Medicine，People’s Hospital of Deqin，Deqin Yunnan，674500，China

Received Date: 2021-06-07
Available Online: 2021-08-04
Publish Date: 2021-08-04

Abstract

Abstract

Objective To investigate the clinical characteristics of newly diagnosed type 2 diabetes mellitus （T2DM） patients among Tibetans in Deqin, analyze the influencing factors of HbA1c, and explore the correlation between HbA1c and hemoglobin （Hb） in Tibetan population at high altitude. Methods Clinical data of 120 tibetan patients with medical examination or receiving diagnosis and treatment in People’ s Hospital of Deqinfrom May 2018 to June 2020 were collected, and they were divided into three groups according to blood glucose level: newly diagnosed type 2 diabetes group, pre-diabetes group and normal glucose tolerance group. General data and laboratory indexes among the three groups were compared. According to hemoglobin level, the subjects were divided into high hemoglobin group and normal hemoglobin group. Fasting plasma glucose （FPG）, two-hour postprandial plasma glucose （2 hPG） and glycosylated hemoglobin （HbA1c） levels between the two groups were compared. The relationship between HbA1c and FPG, 2 hPG and Hb was analyzed by multiple linear regression. Results Comparedwith the normal glucose tolerance group, the diabetes group had higher body mass index （BMI）, triglyceride （TG）, cholesterol （TC）, low density lipoprotein （LDL） and fatty liver ratio （P < 0.05）. There were no significant differences in gender, age, hypertension, high density lipoprotein （HDL）, uric acid （UA）, red blood cell （RBC） and Hb among the three groups. There was no significant difference in FPG, 2 hPG and HbA1c between the high hemoglobin group and the normal hemoglobin group （P > 0.05）. Multiple linear regression analysis showed that both FPG and 2 hPG affected HbA1c, but Hb did not. The regression equation was y = 2.422 + 0.217 × FPG + 0.227 × 2 hPG （R² = 0.73, P < 0.05）. Conclusion BMI, TG, TC and fatty liver in patients with newly diagnosed type 2 diabetes mellitus in Deqin Tibetan nationality is higher, which is a clue for early recognition of diabetes. The main influencing factors of HbA1c were FPG and 2 hPG. Hb was not the influencing factor of HbA1c.
- Type 2 Diabetes,
- Plateau,
- Tibetan,
- Glycosylated hemoglobin

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References(16)

References

[1]	张泽鑫,罗樱樱,刘林,等. 拉萨地区藏族成年人群糖尿病前期及糖尿病患病率初步调查分析[J]. 中国糖尿病杂志,2019,27(8):567-571. doi: 10.3969/j.issn.1006-6187.2019.08.002
[2]	姚勇利,白秀玲. 高原地区红细胞增多人群血红蛋白与HbA1c关系的初步研究[J]. 高原医学杂志,2006,16(2):31-32.
[3]	蒋云海,徐文荣. 论完善健康诊疗机制于少数民族地区精准脱贫的意义—以迪庆藏族自治州德钦县为例[J]. 云南民族大学学报(哲学社会科学版),2019,36(3):95-100.
[4]	中国2型糖尿病防治指南(2020年版)[J]. 中国2型糖尿病防治指南(2020年版)[J]. 中华糖尿病杂志,2021,13(4):315-409.
[5]	中国高血压防治指南修订委员会等. 中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志,2019,24(1):24-56. doi: 10.3969/j.issn.1007-5410.2019.01.002
[6]	赵一多,张瑶,康龙丽. 短期和长期暴露于高海拔地区人群的葡萄糖稳态维持[J]. 国外医学(医学地理分册),2016,37(2):186-194. doi: 10.3969/j.issn.1001-8883.2016.02.026
[7]	Wang L,Gao P,Zhang,M,et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J]. JAMA,2017,317(24):2515-2523. doi: 10.1001/jama.2017.7596
[8]	李彦红,刘学慧. 糖化血红蛋白与糖尿病相关性研究进展[J]. 中国城乡企业卫生,2021,36(06):70-72.
[9]	孙曾梅,邬云红,李秀钧,等. 高原人群糖化血红蛋白的研究进展[J]. 华西医学,2017,32(12):1935-1938.
[10]	李娅,贾德梅,赵滢,等. 高原地区不同人群糖化血红蛋白切点探讨[J]. 中华检验医学杂志,2013,36(2):142-145. doi: 10.3760/cma.j.issn.1009-9158.2013.02.011
[11]	吕雪梅,高赟,邬云红,等. 糖化血红蛋白检测对中国西藏藏族糖尿病及糖尿病前期诊断价值的研究[J]. 中国糖尿病杂志,2013,21(8):686-688. doi: 10.3969/j.issn.1006-6187.2013.08.004
[12]	Ju H B,Yang L P,Fan Jian,et al. Comparison of blood sugar and glycosylated hemoglobin in type 2 diabetic patients of Chinese provinces at different altitudes[J]. Biomed Res,2014,25(3):311-316.
[13]	孙曾梅,王溯源,何华,等. HbA1c对高原不同血红蛋白人群糖代谢异常诊断价值的研究[J]. 国际内分泌代谢杂志,2019,39(2):73-76.
[14]	白玛康卓,巴桑次仁,次仁央宗,等. 不同海拔地区世居藏族人群高原红细胞增多症患病率的流行病学调查[J]. 第三军医大学学报,2016,38(3):220-225.
[15]	唐大东. 高原地区糖尿病患者糖化血红蛋白水平测定及影响因素研究[J]. 山西医药杂志,2017,46(16):1936-1938. doi: 10.3969/j.issn.0253-9926.2017.16.007
[16]	马杜娟,罗玮,蒋艳萍,等. 高原地区肥胖与2型糖尿病及其微血管并发症的研究进展[J]. 青海医药杂志,2021,51(3):61-64.

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