Analysis of Vaginal Microecological in Women with Cervical Intraepithelial Neoplasia and Cervical Cancer

Ding-ji TAN; Hong-li YIN; Rui ZHU; Xi ZHANG; Xin YU; Yong FEI; Xin LI; Ming DUAN; Liang HE; Hong-ying YANG

doi:10.12259/j.issn.2095-610X.S20210821

Volume 42 Issue 8

Aug. 2021

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Ding-ji TAN, Hong-li YIN, Rui ZHU, Xi ZHANG, Xin YU, Yong FEI, Xin LI, Ming DUAN, Liang HE, Hong-ying YANG. Analysis of Vaginal Microecological in Women with Cervical Intraepithelial Neoplasia and Cervical Cancer[J]. Journal of Kunming Medical University, 2021, 42(8): 118-122. doi: 10.12259/j.issn.2095-610X.S20210821

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Analysis of Vaginal Microecological in Women with Cervical Intraepithelial Neoplasia and Cervical Cancer

doi: 10.12259/j.issn.2095-610X.S20210821

Ding-ji TAN¹,
Hong-li YIN²,
Rui ZHU¹,
Xi ZHANG¹,
Xin YU¹,
Yong FEI³,
Xin LI¹,
Ming DUAN¹,
Liang HE^{1
,
,},
Hong-ying YANG^{2
,
,}

1.
Dept. of Laboratory
2.
Dept. of Gynecology
3.
Dept. of Radiology，The 3rd Affiliated Hospital of Kunming Medical University/Cancer Hospital of Yunnan/Cancer Center of Yunnan，Kunming Yunnan 650118，China

Received Date: 2021-06-11
Available Online: 2021-08-03
Publish Date: 2021-08-04

Abstract

Abstract

Objective To investigate the characteristics of vaginal microecology in patients with cervical intraepithelial neoplasia and cervical cancer, and provide information for the prevention and treatment of cervical diseases. Methods From July 2018 to October 2018, patients with cervical intraepithelial neoplasia （n = 65）, patients with cervical cancer （n = 51） and healthy control （n = 88） in Yunnan Cancer Hospital were selected. Vaginal swabs were collected and microecological assessment were performed by microscopic examination. Results Compared with healthy group, there was a significant difference in the composition of bacterial density in the cervical intraepithelial neoplasia group （P < 0.05）, despite there was no significant difference in flora diversity, dominant bacteria, pH and Nugent score （P > 0.05）. There were significant differences in flora density, dominant bacteria, pH and Nugent score composition between the cervical cancer group and the healthy group （P < 0.05） and there was no significance in the composition of bacterial diversity （P > 0.05）. Conclusion Patients with cervical intraepithelial neoplasia and cervical cancer have microecological imbalance, especially in cervical cancer patients. Early detection and restoration of female vaginal microecological imbalance are beneficial for the prevention and treatment of cervical cancer.
- Vaginal microecology,
- Cervical cancer,
- Cervical intraepithelial neoplasia,
- lactobacillus

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References

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