Tiger17 Promotes the Proliferation and Migration of Human Oral Mucosa Fibroblast Cells

Shun-hui YIN; Jian-zhong ZHOU; Zi-liang LI

doi:10.12259/j.issn.2095-610X.S20210823

Volume 42 Issue 8

Aug. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(8): 128-131

Shun-hui YIN, Jian-zhong ZHOU, Zi-liang LI. Tiger17 Promotes the Proliferation and Migration of Human Oral Mucosa Fibroblast Cells[J]. Journal of Kunming Medical University, 2021, 42(8): 128-131. doi: 10.12259/j.issn.2095-610X.S20210823

Citation:

Shun-hui YIN, Jian-zhong ZHOU, Zi-liang LI. Tiger17 Promotes the Proliferation and Migration of Human Oral Mucosa Fibroblast Cells[J]. Journal of Kunming Medical University, 2021, 42(8): 128-131. doi: 10.12259/j.issn.2095-610X.S20210823

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Tiger17 Promotes the Proliferation and Migration of Human Oral Mucosa Fibroblast Cells

doi: 10.12259/j.issn.2095-610X.S20210823

Qianxing Clinic，Affiliated Stomatology Hospital，Kunming Yunnan 650228，China

Received Date: 2021-05-12
Available Online: 2021-08-04
Publish Date: 2021-08-04

Abstract

Abstract

Objective To investigate the effects of different concentrations of Tiger17 on the proliferation and migration of human oral mucosa fibroblast cells （hOMF） for different periods of time. Methods The cells were cultured and migration of hOMF cells treated with different concentrations of Tiger17 for different time were detected by CCK8 and scratch test. The expression levels of TGF-β1, ERK1/2 and p-ERK1/2 in HOMF cells were detected by Western Blot. Results The proliferative activity of hOMF was significantly higher than that of the control group at 48 h （P < 0.05） in 100 μg/mL and 200 μg/mL Tiger17; the migration rate of hOMF was significantly higher than that of the control group at 24 h and 48 h （P < 0.01） in 100 μg/mL Tiger17; different concentrations of Tiger17 acted on hOMF for 24 h and 48 h, the expression of TGF-β1 and p-Erk1/2 protein increased, and the difference was statistically significant （P < 0.05）. Conclusion Tiger17 increases the expression of TGF-β1 and p-Erk1/2 in hOMF cells, and promotes the proliferation and migration of hOMF cells.
- Human oral mucosa fibroblast cells,
- Tiger17,
- Promote,
- Cell proliferation,
- Cell migration

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References(11)

References

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