Advances on Complement Factor H and Cardiovascular Disease

Cheng-zhen ZHU; Xing ZHANG; Hao GUO

doi:10.12259/j.issn.2095-610X.S20210828

Volume 42 Issue 8

Aug. 2021

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Cheng-zhen ZHU, Xing ZHANG, Hao GUO. Advances on Complement Factor H and Cardiovascular Disease[J]. Journal of Kunming Medical University, 2021, 42(8): 158-163. doi: 10.12259/j.issn.2095-610X.S20210828

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Cheng-zhen ZHU, Xing ZHANG, Hao GUO. Advances on Complement Factor H and Cardiovascular Disease[J]. Journal of Kunming Medical University, 2021, 42(8): 158-163. doi: 10.12259/j.issn.2095-610X.S20210828

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Advances on Complement Factor H and Cardiovascular Disease

doi: 10.12259/j.issn.2095-610X.S20210828

Dept. of Cardiology，The 1st Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

Received Date: 2021-03-28
Available Online: 2021-08-04
Publish Date: 2021-08-04

Abstract

Abstract

Cardiovascular diseases is a serious threat to human health, which is characterized by high morbidity, high lethality and disability. In recent years, studies have found that complement factor H （CFH） is a very important negative regulator in the complement system and inflammatory response. The decrease or absence of CFH can continuously activate the complement alternative pathway and enhance the mediated inflammatory response, leading to damage of endothelial cells and cardiomyocytes. CFH plays an important role in the pathogenesis of cardiovascular disease and is involved in the pathophysiology mechanism. This article reviewed the role and mechanism of CFH in the pathogenesis of cardiovascular disease.
- Complement system,
- Complement factor H,
- Cardiovascular diseases

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References(34)

References

[1]	Friese M A,Hellwage J,Jokiranta T S,et al. Different regulation of factor H and FHL-1/reconectin by inflammatory mediators and expression of the two proteins in rheumatoid arthritis (RA)[J]. Clin Exp Immunol,2000,121(2):406-415. doi: 10.1046/j.1365-2249.2000.01285.x
[2]	Jokiranta T S,Hellwage J,Koistinen V,et al. Each of the three binding sites on complement factor H interacts with a distinct site on C3b[J]. J Biol Chem,2000,275(36):27657-27662. doi: 10.1074/jbc.M002903200
[3]	Friese M A,Hellwage J,Jokiranta T S,et al. FHL-1/reconectin and factor H:two human complement regulators which are encoded by the same gene are differently expressed and regulated[J]. Mol Immunol,1999,36(13-14):809-818. doi: 10.1016/S0161-5890(99)00101-7
[4]	Rodriguez de Cordoba S,Esparza-Gordillo J,Goicoechea de Jorge E,et al. The human complement factor H:functional roles,genetic variations and disease associations[J]. Mol Immunol,2004,41(4):355-367. doi: 10.1016/j.molimm.2004.02.005
[5]	李建国,肖慧捷,杨霁云. 补体H因子研究进展[J]. 国外医学(儿科学分册),2005,32(3):143-146.
[6]	Cserhalmi M, Papp A, Brandus B, et al. Regulation of regulators: Role of the complement factor H-related proteins[J]. Semin Immunol, 2019, 45: 101341.
[7]	De Córdoba S R,De Jorge E G. Translational mini‐review series on complement factor H:genetics and disease associations of human complement factor H[J]. Clinical & Experimental Immunology,2008,151(1):1-13.
[8]	Parente R,Clark S J,Inforzato A,et al. Complement factor H in host defense and immune evasion[J]. Cell Mol Life Sci,2017,74(9):1605-1624. doi: 10.1007/s00018-016-2418-4
[9]	Laine M,Jarva H,Seitsonen S,et al. Y402H polymorphism of complement factor H affects binding affinity to creactive protein[J]. The Journal of Immunology,2007,178(6):3831-3836. doi: 10.4049/jimmunol.178.6.3831
[10]	Clark S J,Bishop P N. Role of factor H and related proteins in regulating complement activation in the macula,and relevance to age-related macular degeneration[J]. Journal of Clinical Medicine,2015,4(1):18-31.
[11]	Goodship T H,Cook H T,Fakhouri F,et al. Atypical hemolytic uremic syndrome and C3 glomerulopathy:Conclusions from a “Kidney disease:Improving global outcomes”(KDIGO) controversies conference[J]. Kidney International,2017,91(3):539-551. doi: 10.1016/j.kint.2016.10.005
[12]	Montaniel K R,Harrison D G. Is hypertension a bone marrow disease?[J]. Circulation,2016,134(18):1369-1372. doi: 10.1161/CIRCULATIONAHA.116.024520
[13]	Ruan C C,Gao P J. Role of complement-related inflammation and vascular dysfunction in hypertension[J]. Hypertension,2019,73(5):965-971. doi: 10.1161/HYPERTENSIONAHA.118.11210
[14]	Fritsche L G,Lauer N,Hartmann A,et al. An imbalance of human complement regulatory proteins CFHR1,CFHR3 and factor H influences risk for age-related macular degeneration (AMD)[J]. Human Molecular Genetics,2010,19(23):4694-4704. doi: 10.1093/hmg/ddq399
[15]	Engström G,Hedblad B,Berglund G,et al. Plasma levels of complement C3 is associated with development of hypertension:A longitudinal cohort study[J]. Journal of Human Hypertension,2007,21(4):276-282. doi: 10.1038/sj.jhh.1002129
[16]	Chen L,Fukuda N,Matsumoto T,et al. Role of complement 3 in the pathogenesis of hypertension[J]. Hypertens Res,2020,43(4):255-262. doi: 10.1038/s41440-019-0371-y
[17]	Chen L,Fukuda N,Otsuki T,et al. Increased complement 3 with suppression of miR-145 Induces the synthetic phenotype in vascular smooth muscle cells from spontaneously hypertensive rats[J]. J Am Heart Assoc,2019,8(10):e012327.
[18]	Zhang C,Li Y,Wang C,et al. Complement 5a receptor mediates angiotensin II–Induced cardiac inflammation and remodeling[J]. Arteriosclerosis,Thrombosis,and Vascular Biology,2014,34(6):1240-1248. doi: 10.1161/ATVBAHA.113.303120
[19]	GAN W,WU J,LU L,et al. Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population[J]. PloS One,2012,7(7):e42010. doi: 10.1371/journal.pone.0042010
[20]	Wong T Y,Tikellis G,Sun C,et al. Age-related macular degeneration and risk of coronary heart disease:The atherosclerosis risk in communities study[J]. Ophthalmology,2007,114(1):86-91. doi: 10.1016/j.ophtha.2006.06.039
[21]	Hageman G S,Anderson D H,Johnson L V,et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration[J]. Proceedings of the National Academy of Sciences,2005,102(20):7227-7232.
[22]	Klein R,Knudtson M D,Klein B E,et al. Inflammation,complement factor h,and age-related macular degeneration:the Multi-ethnic Study of Atherosclerosis[J]. Ophthalmology,2008,115(10):1742-1749. doi: 10.1016/j.ophtha.2008.03.021
[23]	Giannakis E,Male D,Ormsby R,et al. Multiple ligand binding sites on domain seven of human complement factor H[J]. Int. Immunopharmacol,2001,1(3):433-443. doi: 10.1016/S1567-5769(00)00040-0
[24]	Pai J K,Manson J E,Rexrode K M,et al. Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women[J]. European Heart Journal,2007,28(11):1297-1303. doi: 10.1093/eurheartj/ehm090
[25]	孙彩琴,陈忠,马根山,等. 早发冠心病患者血浆补体因子H浓度检测及其临床意义[J]. 实用临床医药杂志,2008,12(1):88-89. doi: 10.3969/j.issn.1672-2353.2008.01.024
[26]	钱琦,陈忠,马根山,等. 血浆补体因子H、超敏C反应蛋白和胰岛素抵抗与冠心病的关系[J]. 江苏医药,2009,35(4):382-384.
[27]	Nicaud V,Francomme C,Ruidavets J-B,et al. Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction[J]. Journal of Molecular Medicine,2007,85(7):771-775. doi: 10.1007/s00109-007-0185-2
[28]	孙彩琴,陈忠,马根山. 补体因子H基因^127T/C多态性与早发冠心病的相关性研究[J]. 交通医学,2008,22(6):606-608. doi: 10.3969/j.issn.1006-2440.2008.06.005
[29]	Yndestad A,Damas J K,Qie E,et al. Role of inflammation in the progression of heart failure[J]. Current Cardiology Reports,2007,9(3):236-241. doi: 10.1007/BF02938356
[30]	Suffritti C,Tobaldini E,Schiavon R,et al. Complement and contact system activation in acute congestive heart failure patients[J]. Clinical & Experimental Immunology,2017,190(2):251-257.
[31]	Shahini N,Michelsen A E,Nilsson P H,et al. The alternative complement pathway is dysregulated in patients with chronic heart failure[J]. Scientific Reports,2017,7(42532):2045-2322.
[32]	Hovland A,Jonasson L,Garred P,et al. The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis[J]. Atherosclerosis,2015,241(2):480-494. doi: 10.1016/j.atherosclerosis.2015.05.038
[33]	Ge X,Xu C,Liu Y,et al. Complement activation in the arteries of patients with severe atherosclerosis[J]. Int J Clin Exp Pathol,2018,11(1):1-9.
[34]	An G,Li B,Liu X,et al. Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice[J]. Oncotarget,2016,7(35):56060-56070. doi: 10.18632/oncotarget.11180

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