The Research Progress on the Effect of Prostaglandin E2 on Bone Remodeling

Yun LIU; Hong-bing HE

doi:10.12259/j.issn.2095-610X.S20210916

Volume 42 Issue 9

Sep. 2021

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Yun LIU, Hong-bing HE. The Research Progress on the Effect of Prostaglandin E2 on Bone Remodeling[J]. Journal of Kunming Medical University, 2021, 42(9): 149-155. doi: 10.12259/j.issn.2095-610X.S20210916

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Yun LIU, Hong-bing HE. The Research Progress on the Effect of Prostaglandin E2 on Bone Remodeling[J]. Journal of Kunming Medical University, 2021, 42(9): 149-155. doi: 10.12259/j.issn.2095-610X.S20210916

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The Research Progress on the Effect of Prostaglandin E2 on Bone Remodeling

doi: 10.12259/j.issn.2095-610X.S20210916

Yun LIU,
Hong-bing HE^,

Dept. of Periodontitis，The Affiliated Stomatological Hospital of Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2021-06-14
Available Online: 2021-09-13
Publish Date: 2021-09-30

Abstract

Abstract

Lipid mediators have an important effect on inflammatory bone diseases such as rheumatoid arthritis, osteoarthritis, periodontitis, etc. Among them, PGE₂, which is one of the most important lipid mediators in the process of bone remodeling, plays a significant regulatory role on both osteoblasts and osteoclasts, and participates in the occurrence and development of a variety of inflammatory bone diseases. PGE₂ can mobilize cAMP and RANKL to promote osteoclast formation and increase bone resorption. Furthermore, interleukin （IL）-1- and IL-6-stimulated bone resorption involves PGE₂ production. In addition to its bone-resorptive effffects, PGE₂ promotes the bone formation in vitro by stimulating osteoblastic proliferation and difffferentiation. The multi-faceted nature of PGE₂ makes it difficult to discern its role in bone remodeling. This article reviews the role of PGE₂ in bone reconstruction in recent years.
- Prostaglandin E₂,
- Bone remodeling,
- Inflammatory bone disease,
- Osteoblast,
- Osteoclast

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References(67)

References

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