The Expression and Significance of Pyroptosis Factor Cytokine Caspase-1、IL-1β and IL-18 in Endometrial Polys

Xi-cui LONG; Bei-bei LIU; Shao-bo LU; Zhi-hong LI; Wen-jiao JIN; Jin-zhi LU; Xue-song HAN

doi:10.12259/j.issn.2095-610X.S20210917

Volume 42 Issue 9

Sep. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(9): 51-56

Xi-cui LONG, Bei-bei LIU, Shao-bo LU, Zhi-hong LI, Wen-jiao JIN, Jin-zhi LU, Xue-song HAN. The Expression and Significance of Pyroptosis Factor Cytokine Caspase-1、IL-1β and IL-18 in Endometrial Polys[J]. Journal of Kunming Medical University, 2021, 42(9): 51-56. doi: 10.12259/j.issn.2095-610X.S20210917

Citation:

Xi-cui LONG, Bei-bei LIU, Shao-bo LU, Zhi-hong LI, Wen-jiao JIN, Jin-zhi LU, Xue-song HAN. The Expression and Significance of Pyroptosis Factor Cytokine Caspase-1、IL-1β and IL-18 in Endometrial Polys[J]. Journal of Kunming Medical University, 2021, 42(9): 51-56. doi: 10.12259/j.issn.2095-610X.S20210917

Citation:

Xi-cui LONG, Bei-bei LIU, Shao-bo LU, Zhi-hong LI, Wen-jiao JIN, Jin-zhi LU, Xue-song HAN. The Expression and Significance of Pyroptosis Factor Cytokine Caspase-1、IL-1β and IL-18 in Endometrial Polys[J]. Journal of Kunming Medical University, 2021, 42(9): 51-56. doi: 10.12259/j.issn.2095-610X.S20210917

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The Expression and Significance of Pyroptosis Factor Cytokine Caspase-1、IL-1β and IL-18 in Endometrial Polys

doi: 10.12259/j.issn.2095-610X.S20210917

Dept. of Obstetrics and Gynecology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-07-23
Available Online: 2021-09-13
Publish Date: 2021-09-30

Abstract

Abstract

Objective To detect the expression of caspase-1、IL-1β and IL-18 in endometrial polyps so as to explore the relationship between pyroptosis and endometrial polyps and provide the basis for exploring the pathogenesis of endometrial polyps. Methods In total 30 endometrial polyps specimens （from the observation group） and 30 normal endometrial specimens （from the control group） were collected from the patients visiting the Obstetrics and Gynecology Department of the First Affiliated Hospital of Kunming Medical University from January 2020 to January 2021. The expression of caspase-1, IL-1β and IL-18 in both groups were detected by immunohistochemical method. Results Caspase-1 was mainly expressed in the cytoplasm, the IRS score in the observation group and control group was 4.88±1.82 points and 1.37±1.13 points respectly, caspase-1 express was higher in the observation group （t = 8.95, P < 0.05）. IL-1β was not expressed in both groups. IL-18 was mainly expressed in cytoplasm and nucleus, the IRS score in the observation group and control group was 6.84±2.41 points and 1.73±0.90 points respectly, IL-18 express was higher in observation group （t = 10.87, P < 0.05）. Conclusion Caspase-1 and IL-18 in endometrial polyps is increased, and these two pyroptosis related factors may be involved in the occurrence of endometrial polyps.
- Endometrial polyps,
- Pyroptosis,
- Caspase-1,
- IL-1β,
- IL-18

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