Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury

Sai-ge YIN; Jun SUN; Xin-wang YANG

doi:10.12259/j.issn.2095-610X.S20210929

Volume 42 Issue 9

Sep. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(9): 156-161

Sai-ge YIN, Jun SUN, Xin-wang YANG. Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury[J]. Journal of Kunming Medical University, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929

Citation:

Sai-ge YIN, Jun SUN, Xin-wang YANG. Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury[J]. Journal of Kunming Medical University, 2021, 42(9): 156-161. doi: 10.12259/j.issn.2095-610X.S20210929

Citation:

PDF( 619 KB)

Research Progress of Exogenous Peptide Molecule in Prevention and Treatment of Ischemic Stroke Injury

doi: 10.12259/j.issn.2095-610X.S20210929

Dept. of Anatomy and Histology & Embryology，Faculty of Basic Medical Science， Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2021-06-13
Available Online: 2021-09-28
Publish Date: 2021-09-30

Abstract

Abstract

Ischemic stroke （IS） is one of the main causes of long-term and severe disability due to its high incidence rate, mortality rate, disability rate, and recurrence rate. At present, there is only the only approved recombinant tissue-type plasminogen activator for the treatment of is in the clinic. However, due to its narrow time window and many relative contraindications, the clinical medication is greatly limited. Therefore, the development of new and efficient is neuroprotective drugs has important clinical significance. In recent years, peptide molecular have attracted extensive attention due to their low toxicity, high targeting, and specificity. The prevention and treatment effect of exogenous peptide molecular on IS has also been reported. In this paper, we reviewed the preventive and therapeutic effects and mechanisms of various peptide molecule on IS and provided new molecular biological templates and research ideas for the development of new and efficient neuroprotective drugs for IS.
- Peptide drugs,
- Ischemic stroke,
- Neuroprotection,
- Exogenous application

FullText(HTML)

References(41)

References

[1]	Zhou M,Wang H,Zeng X,et al. Mortality,morbidity,and risk factors in China and its provinces,1990-2017:A systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet,2019,394(10204):1145-1158.
[2]	Meng X,Xie W,Xu Q,et al. Neuroprotective effects of radix scrophulariae on cerebral ischemia and reperfusion injury via MAPK pathways[J]. Molecules,2018,23(9):2401.
[3]	Carmichael S T,Kathirvel U B,Schweppe C A,et al. Molecular,cellular and functional events in axonal sprouting after stroke[J]. Exp Neurol,2017,287(Pt 3):384-394.
[4]	马海燕,陈红华. 中风患者的病情观察及护理体会[J]. 中国中医急症,2004,13(10):708-709. doi: 10.3969/j.issn.1004-745X.2004.10.079
[5]	Barthels D,Das H. Current advances in ischemic stroke research and therapies[J]. Biochim Biophys Acta Mol Basis Dis,2020,1866(4):165260. doi: 10.1016/j.bbadis.2018.09.012
[6]	朱延焱,黄绳武. 肽类药物国内外研究进展[J]. 中国药师,2008,11(7):796-799. doi: 10.3969/j.issn.1008-049X.2008.07.026
[7]	Yang X,Wang Y,Wu C,et al. Animal venom peptides as a treasure trove for new therapeutics against neurodegenerative disorders[J]. Curr Med Chem,2019,26(25):4749-4774. doi: 10.2174/0929867325666181031122438
[8]	齐烨迪,苏慧,陈莉,等. 多肽类药物研究进展[J]. 福建分析测试,2018,27(1):23-29. doi: 10.3969/j.issn.1009-8143.2018.01.07
[9]	Shan Y,Tan S,Lin Y,et al. The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke[J]. J Neuroinflammation,2019,16(1):242. doi: 10.1186/s12974-019-1638-6
[10]	Chen F,Wang W,Ding H,et al. The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia[J]. J Neuroinflammation,2016,13(1):204. doi: 10.1186/s12974-016-0661-0
[11]	Lee C H,Yan B,Yoo K Y,et al. Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist,exendin-4,in experimental transient cerebral ischemia[J]. J Neurosci Res,2011,89(7):1103-1113. doi: 10.1002/jnr.22596
[12]	Teramoto S,Miyamoto N,Yatomi K,et al. Exendin-4,a glucagon-like peptide-1 receptor agonist,provides neuroprotection in mice transient focal cerebral ischemia[J]. J Cereb Blood Flow Metab,2011,31(8):1696-1705. doi: 10.1038/jcbfm.2011.51
[13]	Chen Y,Zhang X,He J,et al. Delayed administration of the glucagon-like peptide 1 analog liraglutide promoting angiogenesis after focal cerebral ischemia in mice[J]. J Stroke Cerebrovasc Dis,2018,27(5):1318-1325. doi: 10.1016/j.jstrokecerebrovasdis.2017.12.015
[14]	Rizk N N,Rafols J A,DunbarU J C. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats:Effects of insulin and C-peptide[J]. Brain Res,2006,1096(1):204-212. doi: 10.1016/j.brainres.2006.04.060
[15]	Fukuoka S,Yeh H,Mandybur T I,et al. Effect of insulin on acute experimental cerebral ischemia in gerbils[J]. Stroke,1989,20(3):396-399. doi: 10.1161/01.STR.20.3.396
[16]	Xing P,Ma K,Wu J,et al. Protective effect of polysaccharide peptide on cerebral ischemia-reperfusion injury in rats[J]. Mol Med Rep,2018,18(6):5371-5378.
[17]	Wang J,Liu Y M,Cao W,et al. Anti-inflammation and antioxidant effect of cordymin,a peptide purified from the medicinal mushroom cordyceps sinensis,in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. Metab Brain Dis,2012,27(2):159-165. doi: 10.1007/s11011-012-9282-1
[18]	Liu Z,Li P,Zhao D,et al. Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. Behavioral and Brain Functions,2010,6(1):1-6. doi: 10.1186/1744-9081-6-1
[19]	何春娇,程琼,丁斐. 牛膝多肽活性成分对大鼠短暂性脑缺血的保护作用[J]. 南通大学学报:医学版,2017,37(2):91-96.
[20]	Bai L,Shi W,Liu J,et al. Protective effect of pilose antler peptide on cerebral ischemia/reperfusion (I/R) injury through Nrf-2/OH-1/NF-kappaB pathway[J]. Int J Biol Macromol,2017,9(102):741-748. doi: 10.1016/j.ijbiomac.2017.04.091
[21]	Lv Z,Qiu L,Jia Z,et al. The activated beta-integrin (CgbetaV) enhances RGD-binding and phagocytic capabilities of hemocytes in Crassostrea gigas[J]. Fish Shellfish Immunol,2019,87(4):638-649. doi: 10.1016/j.fsi.2019.01.047
[22]	Qian L,Wang J,Jiang J,et al. rLj-RGD3,a novel recombinant toxin protein from lampetra japonica,protects against cerebral reperfusion injury following middle cerebral artery occlusion involving the integrin-PI3K/Akt pathway in rats[J]. Plos One,2016,11(10):e0165093.
[23]	Williams A J,Ling G,Berti R,et al. Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats[J]. Exp Brain Res,2003,153(1):16-26. doi: 10.1007/s00221-003-1566-6
[24]	Madden K P,Clark W M,Marcoux F W,et al. Treatment with conotoxin,an 'N-type' calcium channel blocker,in neuronal hypoxic-ischemic injury[J]. Brain Res,1990,537(1-2):256-262. doi: 10.1016/0006-8993(90)90366-J
[25]	Perez-Pinzon M A,Yenari M A,Sun G H,et al. SNX-111,a novel,presynaptic N-type calcium channel antagonist,is neuroprotective against focal cerebral ischemia in rabbits[J]. J Neurol Sci,1997,153(1):25-31. doi: 10.1016/S0022-510X(97)00196-2
[26]	Takizawa S,Matsushima K,Fujita H,et al. A selective N-type calcium channel antagonist reduces extracellular glutamate release and infarct volume in focal cerebral ischemia[J]. J Cereb Blood Flow Metab,1995,15(4):611-618. doi: 10.1038/jcbfm.1995.75
[27]	Zhao Q,Smith M L,Siesjo B K. The omega-conopeptide SNX-111,an N-type calcium channel blocker,dramatically ameliorates brain damage due to transient focal ischaemia[J]. Acta Physiol Scand,1994,150(4):459-461. doi: 10.1111/j.1748-1716.1994.tb09713.x
[28]	Tao J,Yin S,Song Y,et al. Novel scorpion venom peptide HsTx2 ameliorates cerebral ischemic brain injury in rats via the MAPK signaling pathway[J]. Biochem Biophys Res Commun,2021,534(1):442-449. doi: 10.1016/j.bbrc.2020.11.062
[29]	Wang T,Wang S W,Zhang Y,et al. Scorpion venom heat-resistant peptide (SVHRP) enhances neurogenesis and neurite outgrowth of immature neurons in adult mice by up-regulating brain-derived neurotrophic factor (BDNF)[J]. PLoS One,2014,9(10):e109977. doi: 10.1371/journal.pone.0109977
[30]	孔质彬. 蛇毒小分子多肽对大鼠脑缺血再灌注后脑组织肿瘤坏死因子变化的影响[J]. 实用预防医学,2009,16(4):1052-1054. doi: 10.3969/j.issn.1006-3110.2009.04.023
[31]	Li T T,Fan M L,Hou S X,et al. A novel snake venom-derived GPIb antagonist,anfibatide,protects mice from acute experimental ischaemic stroke and reperfusion injury[J]. Br J Pharmacol,2015,172(15):3904-3116. doi: 10.1111/bph.13178
[32]	Mccarthy C A,Rash L D,Chassagnon I R,et al. PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a[J]. Neuropharmacology,2015,99(24):650-657. doi: 10.1016/j.neuropharm.2015.08.040
[33]	Chassagnon I R,Mccarthy C A,Chin Y K,et al. Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a[J]. Proc Natl Acad Sci U S A,2017,114(14):3750-3755. doi: 10.1073/pnas.1614728114
[34]	Pinheiro A C,Gomez R S,Massensini A R,et al. Neuroprotective effect on brain injury by neurotoxins from the spider Phoneutria nigriventer[J]. Neurochem Int,2006,49(5):543-547. doi: 10.1016/j.neuint.2006.04.009
[35]	Guatimosimc,Romano-Silvama,Cruz J S,et al. A toxin from the spider phoneutria nigriventer that blocks calcium channels coupled to exocytosis[J]. Br J Pharmacol,1997,122(3):591-597. doi: 10.1038/sj.bjp.0701381
[36]	MirandaI D M,Romano-Silvama,Kalapothakise,et al. Phoneutria nigriventer toxins block tityustoxin-induced calcium influx in synaptosomes[J]. Neuroreport,1998,9(7):1371-1373. doi: 10.1097/00001756-199805110-00022
[37]	Wang Y R,Liu R Y,Wang L C,et al. Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia[J]. Toxicon,2007,50(8):1085-1094. doi: 10.1016/j.toxicon.2007.07.020
[38]	Yin S,Yang M,LI Y,et al. Peptide OM-LV20 exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats[J]. Biochem Biophys Res Commun,2020,537(Suppl1):36-42.
[39]	沈若武. 扇贝多肽对大鼠脑缺血损伤的保护作用研究 [D]. 青岛: 青岛大学硕士学位论文, 2002.
[40]	林明宝,万丽玲,丁亚思,等. 水蛭多肽对大鼠脑缺血-再灌注损伤的保护作用及其机制[J]. 南昌大学学报(医学版),2015,99(24):650-657.
[41]	王希,武建卓,宋淑亮,等. 水蛭多肽对局灶大鼠脑缺血再灌注损伤保护作用[J]. 中国生化药物杂志,2010,31(1):42-44.

Relative Articles(20)

Relative Articles

[1]	Guojing LIANG, Kun JI, Kaichun ZHANG, Yufang ZHANG, Jing AN, Yuge ZHANG, Juan WEN, Haiyan REN. The Effect of Probiotics on the Expression of Aβ and the Protective Effect of Neurons in Rats with Cerebral Ischemia-Reperfusion Injury. Journal of Kunming Medical University, 2024, 45(5): 37-43. doi: 10.12259/j.issn.2095-610X.S20240506
[2]	Haijun WANG, Liangwu QIU, Yanbin XIYANG, Jundi PANG. Research Progress on Aerobic Exercise Intervention for Learning and Memory Ability in Chronic Cerebral Ischemia. Journal of Kunming Medical University, 2024, 45(3): 186-191. doi: 10.12259/j.issn.2095-610X.S20240328
[3]	Chengcai ZHANG, Rong NING, Na CHEN, Yichen PENG, Li ZHOU, xichen YANG, Jingyi LU, Pengyue ZHANG, Rui LI. Effect of Median Nerve Electrical Stimulation on Synaptic Plasticity in Ischemic Stroke Rats. Journal of Kunming Medical University, 2023, 44(12): 6-12. doi: 10.12259/j.issn.2095-610X.S20231201
[4]	Jing TANG, Jun-chao HUANG, Ya-fei HUANG, Ming-zhu GENG, Xiao-qin MAO, Jian-ping PU. Application of Lipoprotein-associated Phospholipase A2 in Coronary Heart Disease Patients Taking Statins. Journal of Kunming Medical University, 2021, 42(12): 6-10. doi: 10.12259/j.issn.2095-610X.S20211205
[5]	Ma Run , Chen Xiao Hong , Shen Xiu Fen , Tao Shu . . Journal of Kunming Medical University, 2020, 41(08): 88-93.
[6]	Li Ling , Zhang Fang , He Xiao Feng , Hu Jian Rong , Wu Qiong . . Journal of Kunming Medical University, 2019, 40(11): 165-170.
[7]	Jiang Xi Qin , Zhou Xian Ju . . Journal of Kunming Medical University, 2018, 39(10): 143-146.
[8]	Li Ke Xing , Zou Yi , Zhang Li Jiao . Effect of Gangliosides in Improving the Cerebral Blood Flow and Nerve Function Indexes of Newborns with Hypoxic Ischemic Encephalopathy. Journal of Kunming Medical University, 2017, 38(04): 113-116.
[9]	Xie Shu 姮. Changes and Mechanisms of Immunodepression after Ischemic Stroke in Mice. Journal of Kunming Medical University,
[10]	Cheng Bo . . Journal of Kunming Medical University,
[11]	Yu Yang . . Journal of Kunming Medical University,
[12]	Li Dong Bo . . Journal of Kunming Medical University,
[13]	Long Fa Qing . . Journal of Kunming Medical University,
[14]	Wang Zhi Min . . Journal of Kunming Medical University,
[15]	Meng Li Hong . . Journal of Kunming Medical University,
[16]	Yang Li Xin . . Journal of Kunming Medical University,
[17]	Gao Hong . . Journal of Kunming Medical University,
[18]	Peng Guo Hui . . Journal of Kunming Medical University,
[19]	. Clinical Analysis of 113 Caes of Upper Gastrointestinal Bleeding with Ischemic Myocardial Injury. Journal of Kunming Medical University,
[20]	Guo Li Min . . Journal of Kunming Medical University,