Li Hui . Correlation Analysis between Prenatal Infection and Premature Rupture of Membranes[J]. Journal of Kunming Medical University, 2016, 37(08).
Citation: Fu-Jun ZHANG, Rong GONG. Significance of Dynamic Monitoring of T Lymphocyte Subsets and NK Cells in Patients with Esophageal Cancer before and after the Surgery and Chemotherapy[J]. Journal of Kunming Medical University, 2021, 42(9): 46-50. doi: 10.12259/j.issn.2095-610X.S20210935

Significance of Dynamic Monitoring of T Lymphocyte Subsets and NK Cells in Patients with Esophageal Cancer before and after the Surgery and Chemotherapy

doi: 10.12259/j.issn.2095-610X.S20210935
  • Received Date: 2021-07-22
    Available Online: 2021-09-13
  • Publish Date: 2021-09-30
  •   Objective  To explore the clinical value of peripheral blood T lymphocyte subsets and NK cell levels measured at multi-time points in patients with esophageal cancer.  Methods  A total of 39 cases of esophageal cancer patients were enrolled. Flow cytometry was used to detect the T lymphocyte subsets and NK cells in peripheral blood before and after the surgery and chemotherapy. Another 39 cases of healthy adults in the clinic during the same period were included as the control group, and the level of T lymphocyte subsets and NK cells were detected in the same way.  Results  The proportions of lymphocytes subsets and the levels of NK cells in patients with esophageal cancer were significantly lower compared with the control group before the surgery and chemotherapy (P < 0.05), and decreased significantly after the surgery (P < 0.05), the lowest value was found on the 3rd day after the surgery, then increased gradually, the ratio of CD4+/CD8+ didn’ t show the obvious difference in this period. After the chemotherapy, the proportion of CD3+、CD4+ and the ratio of CD4+/CD8+ increased significantly, while the proportion of CD8+ decreased significantly (P < 0.05). 3 weeks after the chemotherapy, the proportions of T lymphocyte subsets were similar to that before the chemotherapy. There was no significant difference in NK cells though it showed a similar trend as T lymphocyte subsets before and after the chemotherapy (P > 0.05).  Conclusion  The immune function of patients with esophageal cancer is in a suppressed state. After the surgery, their immune function reduced temporarily. Chemotherapy can improve this situation but it actually useful in the long term, which may support the idea of effective combinations of chemotherapy and T cell-dependent immunotherapy in a simultaneous or sequential regimen.
  • [1]
    Wang Q,Yang L,Xu F,et al. Changes of Lymphocyte Subgroups in Non-Small Cell Lung Cancer Patients Before and During Chemotherapy[J]. Clinical laboratory,2015,61(10):1343-1351.
    [2]
    Gajewski T F,Woo S R,Zha Y,et al. Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment[J]. Curr Opin Immunol,2013,25(2):268-276. doi: 10.1016/j.coi.2013.02.009
    [3]
    Herbst R S,Soria J C,Kowanetz M,et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients[J]. Nature,2014,515(7528):563-567. doi: 10.1038/nature14011
    [4]
    Hegde P S,Karanikas V,Evers S. The where,the when,and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition[J]. Clin Cancer Res,2016,22(8):1865-1874. doi: 10.1158/1078-0432.CCR-15-1507
    [5]
    国家卫生健康委员会. 食管癌诊疗规范(2018年版)[J]. 中华消化病与影像杂志(电子版),2019,9(4):158-192. doi: 10.3877/cma.j.issn.2095-2015.2019.04.005
    [6]
    Rice T W,Ishwaran H,Ferguson M K,et al. Cancer of the esophagus and esophagogastric junction:An eighth edition staging primer[J]. Journal of Thoracic Oncology,2017,12(1):36-42. doi: 10.1016/j.jtho.2016.10.016
    [7]
    王登峰,雷利强. 食管癌患者外周血T淋巴细胞亚群水平变化及临床意义[J]. 临床医学研究与实践,2018,3(14):91-92.
    [8]
    Ubukata H,Konishi S,Nagata H,et al. Significance of preoperative evaluations of tumor necrosis factor-alpha,the granulocyte/lymphocyte ratio and their correlation with regard to outcome in gastric cancer patients[J]. Digestive Surgery,2010,27(4):324-330. doi: 10.1159/000308461
    [9]
    蔡子仁,王建,周新明,等. 开胸与胸腔镜手术影响肺癌患者术后调节T细胞功能和T淋巴细胞亚群的临床研究[J]. 河北医药,2019,41(19):2944-2947. doi: 10.3969/j.issn.1002-7386.2019.19.016
    [10]
    Gomatos I P,Alevizos L,Kalathaki O,et al. Changes in T-lymphocytes’viability after laparoscopic versus open cholecystectomy[J]. Int Surg,2015,100(4):696-701. doi: 10.9738/INTSURG-D-14-00137.1
    [11]
    罗俐梅,罗娅,蔡宜含,等. 外周血淋巴细胞绝对计数在结直肠癌和食管癌肿瘤进展与治疗前后免疫状态评估的临床应用研究[J]. 中华临床实验室管理电子杂志,2019,7(3):137-144.
    [12]
    Westerterp M,Boermeester M A,Omloo J M,et al. Differential responses of cellular immunity in patients undergoing neoadjuvant therapy followed by surgery for carcinoma of the oesophagus[J]. Cancer Immunology,Immunotherapy,2008,57(12):1837-1847.
    [13]
    崔鹏龙,何世杰. 全麻复合硬膜外麻醉对肺癌根治术患者外周血T细胞亚群及NK细胞活性的影响[J]. 实用癌症杂志,2020,35(2):212-214. doi: 10.3969/j.issn.1001-5930.2020.02.011
    [14]
    陈榕,陈国平,汪家航,等. 乳腺癌患者围手术期免疫指标的变化及其临床意义[J]. 中华肿瘤杂志,2019(11):849-853. doi: 10.3760/cma.j.issn.0253-3766.2019.11.009
    [15]
    Krijgsman D,de Vries N L,Skovbo A,et al. Characterization of circulating T-,NK-,and NKT cell subsets in patients with colorectal cancer:The peripheral blood immune cell profile[J]. Cancer Immunology,Immunotherapy,2019,68(6):1011-1024.
    [16]
    Ogura M,Ishida T,Tsukasaki K,et al. Effects of first-line chemotherapy on natural killer cells in adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma[J]. Cancer Chemother Pharmacol,2016,78(1):199-207. doi: 10.1007/s00280-016-3070-2
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