Significance of Dynamic Monitoring of T Lymphocyte Subsets and NK Cells in Patients with Esophageal Cancer before and after the Surgery and Chemotherapy

Fu-Jun ZHANG; Rong GONG

doi:10.12259/j.issn.2095-610X.S20210935

Volume 42 Issue 9

Sep. 2021

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Du Rong , Xu Bi Zhi . Investigation on the Secondary Epilepsy Occurrence of Patients with Cerebral Infarction and Its Risk Factors[J]. Journal of Kunming Medical University, 2018, 39(04): 100-103.

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Fu-Jun ZHANG, Rong GONG. Significance of Dynamic Monitoring of T Lymphocyte Subsets and NK Cells in Patients with Esophageal Cancer before and after the Surgery and Chemotherapy[J]. Journal of Kunming Medical University, 2021, 42(9): 46-50. doi: 10.12259/j.issn.2095-610X.S20210935

Du Rong , Xu Bi Zhi . Investigation on the Secondary Epilepsy Occurrence of Patients with Cerebral Infarction and Its Risk Factors[J]. Journal of Kunming Medical University, 2018, 39(04): 100-103.

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Significance of Dynamic Monitoring of T Lymphocyte Subsets and NK Cells in Patients with Esophageal Cancer before and after the Surgery and Chemotherapy

doi: 10.12259/j.issn.2095-610X.S20210935

Fu-Jun ZHANG¹,
Rong GONG^{2
,
,}

1.
Dept. of Geriatric Thoracic Surgery，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Yunnan Key Laboratory of Laboratory Medicine，Yunnan Institute of Experimental Diagnosis，Dept. of Clinical Laboratory，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-07-22
Available Online: 2021-09-13
Publish Date: 2021-09-30

Abstract

Abstract

Objective To explore the clinical value of peripheral blood T lymphocyte subsets and NK cell levels measured at multi-time points in patients with esophageal cancer. Methods A total of 39 cases of esophageal cancer patients were enrolled. Flow cytometry was used to detect the T lymphocyte subsets and NK cells in peripheral blood before and after the surgery and chemotherapy. Another 39 cases of healthy adults in the clinic during the same period were included as the control group, and the level of T lymphocyte subsets and NK cells were detected in the same way. Results The proportions of lymphocytes subsets and the levels of NK cells in patients with esophageal cancer were significantly lower compared with the control group before the surgery and chemotherapy （P < 0.05）, and decreased significantly after the surgery （P < 0.05）, the lowest value was found on the 3rd day after the surgery, then increased gradually, the ratio of CD4⁺/CD8⁺ didn’ t show the obvious difference in this period. After the chemotherapy, the proportion of CD3⁺、CD4⁺ and the ratio of CD4⁺/CD8⁺ increased significantly, while the proportion of CD8+ decreased significantly （P < 0.05）. 3 weeks after the chemotherapy, the proportions of T lymphocyte subsets were similar to that before the chemotherapy. There was no significant difference in NK cells though it showed a similar trend as T lymphocyte subsets before and after the chemotherapy （P > 0.05）. Conclusion The immune function of patients with esophageal cancer is in a suppressed state. After the surgery, their immune function reduced temporarily. Chemotherapy can improve this situation but it actually useful in the long term, which may support the idea of effective combinations of chemotherapy and T cell-dependent immunotherapy in a simultaneous or sequential regimen.
- Esophageal cancer,
- T lymphocyte subsets,
- NK cell,
- Surgery,
- Chemotherapy

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References

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