Changes and Clinical Significance of Plasma sTREM-1，sFLT-1 and SOD Levels in Patients with Severe Pneumonia

Zheng-gao FU; Yu CHEN; Yong LIANG; Jun-xu XU; Ting-shi WU; Jin-xiang HAO

doi:10.12259/j.issn.2095-610X.S20211006

Volume 42 Issue 10

Oct. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(10): 132-138

Zheng-gao FU, Yu CHEN, Yong LIANG, Jun-xu XU, Ting-shi WU, Jin-xiang HAO. Changes and Clinical Significance of Plasma sTREM-1，sFLT-1 and SOD Levels in Patients with Severe Pneumonia[J]. Journal of Kunming Medical University, 2021, 42(10): 132-138. doi: 10.12259/j.issn.2095-610X.S20211006

Citation:

Zheng-gao FU, Yu CHEN, Yong LIANG, Jun-xu XU, Ting-shi WU, Jin-xiang HAO. Changes and Clinical Significance of Plasma sTREM-1，sFLT-1 and SOD Levels in Patients with Severe Pneumonia[J]. Journal of Kunming Medical University, 2021, 42(10): 132-138. doi: 10.12259/j.issn.2095-610X.S20211006

Citation:

Zheng-gao FU, Yu CHEN, Yong LIANG, Jun-xu XU, Ting-shi WU, Jin-xiang HAO. Changes and Clinical Significance of Plasma sTREM-1，sFLT-1 and SOD Levels in Patients with Severe Pneumonia[J]. Journal of Kunming Medical University, 2021, 42(10): 132-138. doi: 10.12259/j.issn.2095-610X.S20211006

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Changes and Clinical Significance of Plasma sTREM-1，sFLT-1 and SOD Levels in Patients with Severe Pneumonia

doi: 10.12259/j.issn.2095-610X.S20211006

Dept. of Respiratory Critical Illness Medicine，Haikou Third People’s Hospital，Haikou Hainan 571100，China

Received Date: 2021-07-26
Available Online: 2021-10-29
Publish Date: 2021-10-30

Abstract

Abstract

Objective To investigate the changes and clinical significance of plasma levels of soluble myeloid cell trigger receptor-1 （sTREM-1）, soluble Fms-like tyrosine kinase receptor-1 （sFLT-1） and superoxide dismutase （SOD） in patients with severe pneumonia （SP）. Methods A total of 150 patients with pneumonia admitted to our hospital （January 2018 to January 2019） were selected and divided into normal pneumonia group （n = 63） and SP group （n = 87） according to their condition, follow-up for 28 days after treatment, SP was divided into death group （n = 32） and survival group （n = 55） according to whether or not they died, and 60 healthy people who had physical examination during the same period were selected as control group.The plasma levels of sTREM-1, sFLT-1, and SOD in each group were compared, multivariate Logistics regression was used to analyze the factors affecting the adverse prognosis of SP patients, the ROC curve analyzed the predictive value of plasma sTREM-1, sFLT-1, and SOD levels on the adverse prognosis of SP patients. Results The plasma levels of sTREM-1 and sFLT-1 in the control group, common pneumonia group and SP group gradually increased, while the SOD level gradually decreased （P < 0.05）.Multivariate logistic regression analysis showed that intensive care unit （ICU） time （OR = 1.784, 95%CI: 1.077～2.955）, Acute Physiology and Chronic Health Assessment Ⅱ （APACHE Ⅱ） score （OR = 1.834, 95%CI: 1.130～2.976）, sTREM-1 （OR = 1.236, 95%CI: 1.034～1.477）, sFLT-1 （OR = 1.095, 95%CI: 1.026～1.169） was an independent risk factor for poor prognosis in SP patients, arterial blood oxygen pressure （PaO₂）（OR = 0.894, 95%CI: 0.809～0.988）, SOD （OR = 0.933, 95%CI: 0.879～0.990） was a protective factor （P < 0.05）.The ROC curve showed that the sensitivity and specificity of sTREm-1+sFLT-1+SOD （AUC = 0.913, 95%CI: 0.833～0.963） in predicting the poor prognosis of SP patients were higher than those of sTREm-1 （AUC = 0.799, 95%CI: 0.699～0.877）, sFLT-1 （AUC = 0.780, 95%CI: 0.678～0.861）, and SOD （AUC = 0.801, 95%CI: 0.701～0.879）. Conclusions Plasma sTREM-1 and sFLT-1 levels in SP patients are significantly increased, and SOD levels are significantly reduced. These are independent factors affecting poor prognosis. Combined detection can increase the predictive value of poor prognosis.
- Severe pneumonia,
- Plasma,
- Soluble myeloid cell trigger receptor-1,
- Soluble Fms-like tyrosine kinase receptor-1,
- Superoxide dismutase

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References(19)

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