Changes and Abnormal Patterns of Coagulation Indicators in Patients with Lung Adenocarcinoma and Tuberculosis Pleural Effusion

Yan-fen MA; Jian HU; Ning ZHANG; Qian WU; Xiao-qin WANG

doi:10.12259/j.issn.2095-610X.S20211021

Volume 42 Issue 10

Oct. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(10): 145-150

Yan-fen MA, Jian HU, Ning ZHANG, Qian WU, Xiao-qin WANG. Changes and Abnormal Patterns of Coagulation Indicators in Patients with Lung Adenocarcinoma and Tuberculosis Pleural Effusion[J]. Journal of Kunming Medical University, 2021, 42(10): 145-150. doi: 10.12259/j.issn.2095-610X.S20211021

Citation:

Yan-fen MA, Jian HU, Ning ZHANG, Qian WU, Xiao-qin WANG. Changes and Abnormal Patterns of Coagulation Indicators in Patients with Lung Adenocarcinoma and Tuberculosis Pleural Effusion[J]. Journal of Kunming Medical University, 2021, 42(10): 145-150. doi: 10.12259/j.issn.2095-610X.S20211021

Citation:

Yan-fen MA, Jian HU, Ning ZHANG, Qian WU, Xiao-qin WANG. Changes and Abnormal Patterns of Coagulation Indicators in Patients with Lung Adenocarcinoma and Tuberculosis Pleural Effusion[J]. Journal of Kunming Medical University, 2021, 42(10): 145-150. doi: 10.12259/j.issn.2095-610X.S20211021

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Changes and Abnormal Patterns of Coagulation Indicators in Patients with Lung Adenocarcinoma and Tuberculosis Pleural Effusion

doi: 10.12259/j.issn.2095-610X.S20211021

Clinical Laboratory of The First Affiliated Hospital，Xi’an Jiaotong University， Xi’an Shanxi 710061，China

Received Date: 2021-07-29
Available Online: 2021-10-29
Publish Date: 2021-10-30

Abstract

Abstract

Objective To assesse the changes and abnormal patterns of coagulation indicators in distinguishing malignant pleural effusion of lung adenocarcinoma （AD-MPE） and tuberculous pleural effusion （TPE） and acquire the optimal diagnostic model. Methods Patients with 200 AD-MPEs or 209 TPEs participated in this retrospective study. Coagulation function indicators, including activated partial thromboplastin time （APPT）, prothrombin time （PT）, fibrinogen （FIB）, thrombin time （TT）, fibrinogen degradation products （FDP）, and D-dimer（D-D）, were measured; their levels and abnormal patterns were analyzed separately and in combination, to determine the diagnostic performance of individual and combined values and the optimal diagnostic model. Results PT, FIB, FDP, and D-Dlevels in patients with TPE were significantly higher than those in patients with AD-MPE （all P < 0.01）. PT, FIB, FDP, and D-D values, particularly FDP and D-D, could distinguish between AD-MPE and TPE. The diagnostic performance was better for the combination of the four indicators and their abnormal patterns than for any single indicator （area under the curve: 0.732）. The proportion of patients with abnormal patterns of all four indicators was significantly higher in those with TPE than in those with AD-MPE （all P < 0.001）. Conclusions In the two groups of patients, the levels and abnormal patterns of PT, FIB, FDP and D-D are not the same. The combination of the four indicators and their abnormal patterns is helpful for the differential diagnosis of TPE and AD-MPE.
- Pleural effusion,
- Coagulation indicators,
- Tuberculosis,
- Lung adenocarcinoma

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References(17)

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