Clinical Application of Xenogenic Acellular （bovine） Dermal Matrix with Autologous Bone Powder Implantation in Open Mastoidectomy

Li -zhu WANG; Shu-ling LI; Biao RUAN

doi:10.12259/j.issn.2095-610X.S20211029

Volume 42 Issue 10

Oct. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(10): 99-105

Li -zhu WANG, Shu-ling LI, Biao RUAN. Clinical Application of Xenogenic Acellular （bovine） Dermal Matrix with Autologous Bone Powder Implantation in Open Mastoidectomy[J]. Journal of Kunming Medical University, 2021, 42(10): 99-105. doi: 10.12259/j.issn.2095-610X.S20211029

Citation:

Li -zhu WANG, Shu-ling LI, Biao RUAN. Clinical Application of Xenogenic Acellular （bovine） Dermal Matrix with Autologous Bone Powder Implantation in Open Mastoidectomy[J]. Journal of Kunming Medical University, 2021, 42(10): 99-105. doi: 10.12259/j.issn.2095-610X.S20211029

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Clinical Application of Xenogenic Acellular （bovine） Dermal Matrix with Autologous Bone Powder Implantation in Open Mastoidectomy

doi: 10.12259/j.issn.2095-610X.S20211029

Dept. of Otorhinolaryngology，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-07-28
Available Online: 2021-10-29
Publish Date: 2021-10-30

Abstract

Abstract

Objective To investigate the application of xenogenic acellular （bovine） dermal matrix （ADM） combined with autologous bone powder implantation in open mastoidectomy, and investigate the effect on ear drying, epithelization, survival of autogenous bone meal and reduction of postoperative infection rate. Methods From September 2016 to September 2020, patients with otitis media who were treated by surgery in department I of Otolaryngology, First Affiliated Hospital of Kunming Medical University were divided into three groups according to the requirements of this study: （1） Patients with otitis media who underwent open radical mastoidectomy + xenogeneic （bovine） acellular dermal matrix combined with autologous bone meal implantation （experimental group）; （2） Patients with otitis media underwent open radical mastoidectomy and fascia combined with autologous bone meal implantation （experimental control group）; （3） Otitis media were treated with open radical mastoidectomy and fascia implantation （blank control group）; At 2 weeks, 4 weeks, 6 weeks and 8 weeks after operation, the following four aspects were recorded: （1） dry ear; （2） epithelization; （3） survival of bone powder; （4） infection Results. After 2 weeks, 4 weeks, 6 weeks, the incidence of dry ear and the incidence of epithelization between 4 weeks, 6 weeks after operation were compared. The chi square test showed that the results were P < 0.001, which was statistically significant. The test level was adjusted and compared. Results The blank control group, the experimental control group and the experimental group were all P < 0.001. The incidence of dry ear and epithelialization in the experimental group was higher than that in the blank control group and the experimental control group at 6 weeks and 4 and 6 weeks after operation, but there was no difference between the blank control group and the experimental control group; There was no significant difference in the infection rate among the three groups at 2, 4 and 6 weeks after operation （P > 0.05）. The incidence of dry ear, epithelization and infection were compared between the two groups on the 8th week after operation, and the results were all P > 0.05, without statistical significance. Conclusions Xenogenic acellular （bovine） dermal matrix （ADM） combined with autologous bone powder implantation in open radical mastoidectomy can significantly shorten the dry ear time and epithelialize quickly after operation. It can achieve dry ear and epithelialization within 4 to 6 weeks after operation, and ensure the survival of autologous bone powder implantation, thus effectively reducing the incidence of infection after operation, improving long-term efficacy.
- Xenogenic acellular （bovine） dermal matrix,
- Dry ear,
- Epithelialization,
- Autogenous bone meal,
- Infection

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References(16)

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