Clinical Investigation of Vitamin D and Calcium Supplement’ Effect on the Occurrence of Cardiovascular and Cerebrovascular Diseases in POP Patients

Ling-ling YAN; Zhi-hong QIAN; Yue NI; Huang WU

doi:10.12259/j.issn.2095-610X.S20211036

Volume 42 Issue 10

Oct. 2021

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Ling-ling YAN, Zhi-hong QIAN, Yue NI, Huang WU. Clinical Investigation of Vitamin D and Calcium Supplement’ Effect on the Occurrence of Cardiovascular and Cerebrovascular Diseases in POP Patients[J]. Journal of Kunming Medical University, 2021, 42(10): 139-144. doi: 10.12259/j.issn.2095-610X.S20211036

Citation:

Ling-ling YAN, Zhi-hong QIAN, Yue NI, Huang WU. Clinical Investigation of Vitamin D and Calcium Supplement’ Effect on the Occurrence of Cardiovascular and Cerebrovascular Diseases in POP Patients[J]. Journal of Kunming Medical University, 2021, 42(10): 139-144. doi: 10.12259/j.issn.2095-610X.S20211036

Citation:

Ling-ling YAN, Zhi-hong QIAN, Yue NI, Huang WU. Clinical Investigation of Vitamin D and Calcium Supplement’ Effect on the Occurrence of Cardiovascular and Cerebrovascular Diseases in POP Patients[J]. Journal of Kunming Medical University, 2021, 42(10): 139-144. doi: 10.12259/j.issn.2095-610X.S20211036

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Clinical Investigation of Vitamin D and Calcium Supplement’ Effect on the Occurrence of Cardiovascular and Cerebrovascular Diseases in POP Patients

doi: 10.12259/j.issn.2095-610X.S20211036

1.
Dept. of Cardiovascular Medicine，Liyang Municipal People’s Hospital，Jiangsu Liyang 213300
2.
Dept. of Bone Surgery，The Second People’s Hospital of Three Gorges University，Yichang Municipal Second People’s Hospital，Hubei Yichang 443000，China

Received Date: 2021-07-05
Available Online: 2021-10-29
Publish Date: 2021-10-30

Abstract

Abstract

Objective To investigate the vitamin D （VD） and calcium supplement’effect on the occurrence of cardiovascular and cerebrovascular diseases in Primary osteoporosis （POP） patients accompanied with hypertension or coronary heart disease. Methods From October 2018 to September 2019, the 317 cases diagnosed as hypertension or coronary heart disease accompanied with primary osteoporosis diagnosis and complying with inclusion criteria in Cardiovascular department of Liyang Municipal People’s Hospital were recruited, divided into hypertension and coronary heart disease groups, with 224 and 93 participants in each group. Then participants in each group were again divided into VD deficiency （25（OH）D≤20 ng/mL） and severe deficiency （25（OH）D≤10 ng/mL） groups, treated with one Calcium carbonate D3 pill and two pills per day, respectively. Treatment lasts for 18 months, during which the participants should recorded the occurrence times of angina pectoris （including myocardial infarction）, atherosclerosis （newly occurrence except for coronary）, lower limbs’ venous thrombosis and cerebral infarction, which forced the participant to turn to hospital, as well as the VD and Ca concentrations examined during the periods. The occurrence and non-occurrence proportion and VD and Ca concentrations between the two groups among the corresponding group were compared. Results POP hypertension groups: The incidents proportion of heart, cerebral and vessels diseases in VD severe deficiency group （19.0%） was higher than that （7.5%） of VD deficiency group, P = 0.018. There was an obviously positive correlation between VD and Ca, P < 0.001. Compared with VD deficiency group, the VD and Ca levels of VD severe deficiency group at the occurrence of angina pectoris were higher, P < 0.05. POP coronary heart disease groups: The incidents proportion of heart, cerebral and vessels diseases in VD severe deficiency group （86.2%） was higher than that （62.7%） of VD deficiency group, P = 0.030. There was an obviously positive correlation between VD and Ca, P < 0.001. Compared with VD deficiency group, the VD and Ca levels of VD severe deficiency group at the occurrence of angina pectoris were higher, P < 0.05 and P < 0.01, respectively. When suffering from atherosclerosis, the Ca level of participants in VD severe deficiency group was higher than that in VD deficiency group, P < 0.05, with a increasing trend of VD level. Conclusion Properly added VD and decreased Ca supplement might be suitable for hypertension accompanied with POP patients with VD severe deficiency. For coronary heart disease accompanied with POP patients with VD severe deficiency, decreased VD and Ca supplement may be more fit.
- Vitamin D,
- Calcium,
- Primary osteoporosis,
- Cardiovascular diseases

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References(17)

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