Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province

Jia YANG; Ya-xian LI; Ying-ying WANG; Lin XIAO; Chuan-yin LI; Fang TAN; Qian-li MA; Shu-yuan LIU

doi:10.12259/j.issn.2095-610X.S20211037

Volume 42 Issue 10

Oct. 2021

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Jia YANG, Ya-xian LI, Ying-ying WANG, Lin XIAO, Chuan-yin LI, Fang TAN, Qian-li MA, Shu-yuan LIU. Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province[J]. Journal of Kunming Medical University, 2021, 42(10): 22-28. doi: 10.12259/j.issn.2095-610X.S20211037

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Jia YANG, Ya-xian LI, Ying-ying WANG, Lin XIAO, Chuan-yin LI, Fang TAN, Qian-li MA, Shu-yuan LIU. Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province[J]. Journal of Kunming Medical University, 2021, 42(10): 22-28. doi: 10.12259/j.issn.2095-610X.S20211037

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Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20211037

1.
Dept. of Immunogenetics，Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
3.
The Third Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2021-08-08
Available Online: 2021-10-29
Publish Date: 2021-10-30

Abstract

Abstract

Objectives To investigate the relationship between mircoRNA gene polymorphisms and the occurrence and development of non-small cell lung cancer in Yunnan Han population. Methods A total of 415 lung cancer patients of non-small cell lung cancer and 460 healthy individuals were included from Yunnan Han population. The genotypes of 3 polymorphism loci, rs2292832 T>C（pre-miR-149）, rs107822 C>T（pre-miR- 219a-1）, rs629367 C>A（pri-let-7a-1）were detected by TaqmanSNP genotyping assay. The distribution of allele and genotype frequency in lung cancer patients and healthy controls were analyzed. Results There was no significant difference of the allele and genotype frequency of 3 SNPs. And in stratification analysis, there was also no significant difference. Conclusions rs2292832, rs107822, rs629367 may not be significantly associated with non-small cell lung cancer in Yunnan Han population.
- Non-small cell lung cancer,
- miRNA,
- SNPs,
- Association,
- Yunnan Han population

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References(24)

References

[1]	Sung H,Ferlay J,Siegel R L,et al. Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2021,71(3):209-249. doi: 10.3322/caac.21660
[2]	郑荣寿,孙可欣,张思维,等. 2015年中国恶性肿瘤流行情况分析[J]. 中华肿瘤杂志,2019,(1):19-28. doi: 10.3760/cma.j.issn.0253-3766.2019.01.005
[3]	Albright F,Teerlink C,Werner T L,et al. Significant evidence for a heritable contribution to cancer predisposition:a review of cancer familiality by site[J]. BMC Cancer,2012,12:138. doi: 10.1186/1471-2407-12-138
[4]	Saliminejad K,Khorram Khorshid H R,Soleymani Fard S,et al. An overview of microRNAs:Biology,functions,therapeutics,and analysis methods[J]. J Cell Physiol,2019,234(5):5451-5465. doi: 10.1002/jcp.27486
[5]	Liao J,Shen J,Leng Q,et al. MicroRNA-based biomarkers for diagnosis of non-small cell lung cancer (NSCLC)[J]. Thorac Cancer,2020,11(3):762-768. doi: 10.1111/1759-7714.13337
[6]	Ryan B M,Robles A I and Harris C C. Genetic variation in microRNA networks:the implications for cancer research[J]. Nat Rev Cancer,2010,10(6):389-402. doi: 10.1038/nrc2867
[7]	Lin J,Zandi R,Shao R,et al. A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling[J]. Sci Rep,2017,7(1):9029. doi: 10.1038/s41598-017-09604-4
[8]	Beasley M B,Brambilla E and Travis W D. The 2004 World Health Organization classification of lung tumors[J]. Semin Roentgenol,2005,40(2):90-97. doi: 10.1053/j.ro.2005.01.001
[9]	Groome P A,Bolejack V,Crowley J J,et al. The IASLC Lung Cancer Staging Project:validation of the proposals for revision of the T,N,and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours[J]. J Thorac Oncol,2007,2(8):694-705. doi: 10.1097/JTO.0b013e31812d05d5
[10]	Shi Y Y and He L. SHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci[J]. Cell Res,2005,15(2):97-98. doi: 10.1038/sj.cr.7290272
[11]	Solé X,Guinó E,Valls J,et al. SNPStats:a web tool for the analysis of association studies[J]. Bioinformatics,2006,22(15):1928-1929. doi: 10.1093/bioinformatics/btl268
[12]	Wu M,Wang G,Tian W,et al. MiRNA-based Therapeutics for Lung Cancer[J]. Curr Pharm Des,2018,23(39):5989-5996. doi: 10.2174/1381612823666170714151715
[13]	Mishra S,Yadav T and Rani V. Exploring miRNA based approaches in cancer diagnostics and therapeutics[J]. Crit Rev Oncol Hematol,2016,98:12-23. doi: 10.1016/j.critrevonc.2015.10.003
[14]	Wang R J,Zheng Y H,Wang P,et al. Serum miR-125a-5p,miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancer[J]. Int J Clin Exp Pathol,2015,8(1):765-771.
[15]	Li C,Zhang Y,Li Y,et al. The association of polymorphisms in miRNAs with nonsmall cell lung cancer in a Han Chinese population[J]. Cancer Manag Res,2018,10:697-704. doi: 10.2147/CMAR.S154040
[16]	Dikeakos P,Theodoropoulos G,Rizos S,et al. Association of the miR-146aC>G,miR-149T>C,and miR-196a2T>C polymorphisms with gastric cancer risk and survival in the Greek population[J]. Mol Biol Rep,2014,41(2):1075-1080. doi: 10.1007/s11033-013-2953-0
[17]	Wei W J,Lu Z W,Li D S,et al. Association of the miR-149 Rs2292832 polymorphism with papillary thyroid cancer risk and clinicopathologic characteristics in a Chinese population[J]. Int J Mol Sci,2014,15(11):20968-20981. doi: 10.3390/ijms151120968
[18]	Tu H F,Liu C J,Chang C L,et al. The association between genetic polymorphism and the processing efficiency of miR-149 affects the prognosis of patients with head and neck squamous cell carcinoma[J]. PLoS One,2012,7(12):e51606. doi: 10.1371/journal.pone.0051606
[19]	Zhang M,Jin M,Yu Y,et al. Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population[J]. Eur J Cancer Care (Engl),2012,21(2):274-280. doi: 10.1111/j.1365-2354.2011.01308.x
[20]	Lv M,Dong W,Li L,et al. Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population[J]. J Cancer Res Clin Oncol,2013,139(8):1405-1410. doi: 10.1007/s00432-013-1456-7
[21]	Stenholm L,Stoehlmacher-Williams J,Al-Batran S E,et al. Prognostic role of microRNA polymorphisms in advanced gastric cancer:a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)[J]. Ann Oncol,2013,24(10):2581-2588. doi: 10.1093/annonc/mdt330
[22]	Zheng C,Li X,Xia L,et al. Polymorphisms of pri-miR-219-1 are associated with the susceptibility and prognosis of non-small cell lung cancer in a Northeast Chinese population[J]. Oncotarget,2017,8(34):56533-56541. doi: 10.18632/oncotarget.17035
[23]	Song X,You W,Zhu J,et al. A Genetic Variant in miRNA-219-1 Is Associated with Risk of Esophageal Squamous Cell Carcinoma in Chinese Kazakhs[J]. Dis Markers,2015,54:1531.
[24]	Xu Q,Dong Q,He C,et al. A new polymorphism biomarker rs629367 associated with increased risk and poor survival of gastric cancer in chinese by up-regulated miRNA-let-7a expression[J]. PLoS One,2014,9(4):e95249. doi: 10.1371/journal.pone.0095249

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