Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province

Jia YANG; Ya-xian LI; Ying-ying WANG; Lin XIAO; Chuan-yin LI; Fang TAN; Qian-li MA; Shu-yuan LIU

doi:10.12259/j.issn.2095-610X.S20211037

Volume 42 Issue 10

Oct. 2021

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Jia YANG, Ya-xian LI, Ying-ying WANG, Lin XIAO, Chuan-yin LI, Fang TAN, Qian-li MA, Shu-yuan LIU. Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province[J]. Journal of Kunming Medical University, 2021, 42(10): 22-28. doi: 10.12259/j.issn.2095-610X.S20211037

Citation:

Jia YANG, Ya-xian LI, Ying-ying WANG, Lin XIAO, Chuan-yin LI, Fang TAN, Qian-li MA, Shu-yuan LIU. Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province[J]. Journal of Kunming Medical University, 2021, 42(10): 22-28. doi: 10.12259/j.issn.2095-610X.S20211037

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Association of the miR-149,miR-219 and miR-let-7 Polymorphisms with the Occurrence and Development of Non-small Cell Lung Cancer in a Chinese Han Population in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20211037

1.
Dept. of Immunogenetics，Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
3.
The Third Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2021-08-08
Available Online: 2021-10-29
Publish Date: 2021-10-30

Abstract

Abstract

Objectives To investigate the relationship between mircoRNA gene polymorphisms and the occurrence and development of non-small cell lung cancer in Yunnan Han population. Methods A total of 415 lung cancer patients of non-small cell lung cancer and 460 healthy individuals were included from Yunnan Han population. The genotypes of 3 polymorphism loci, rs2292832 T>C（pre-miR-149）, rs107822 C>T（pre-miR- 219a-1）, rs629367 C>A（pri-let-7a-1）were detected by TaqmanSNP genotyping assay. The distribution of allele and genotype frequency in lung cancer patients and healthy controls were analyzed. Results There was no significant difference of the allele and genotype frequency of 3 SNPs. And in stratification analysis, there was also no significant difference. Conclusions rs2292832, rs107822, rs629367 may not be significantly associated with non-small cell lung cancer in Yunnan Han population.
- Non-small cell lung cancer,
- miRNA,
- SNPs,
- Association,
- Yunnan Han population

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References(24)

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