Comparison of Six Methods of Ultrasound-guided Fine-needle Aspiration Biopsy of Thyroid Nodules

Lin WEI; Yu-ran FENG; Hui YUAN; Ke-yu ZHOU; Yi ZHAO; Jun QIAN; Mei ZHU

doi:10.12259/j.issn.2095-610X.S20211044

Volume 42 Issue 10

Oct. 2021

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Lin WEI, Yu-ran FENG, Hui YUAN, Ke-yu ZHOU, Yi ZHAO, Jun QIAN, Mei ZHU. Comparison of Six Methods of Ultrasound-guided Fine-needle Aspiration Biopsy of Thyroid Nodules[J]. Journal of Kunming Medical University, 2021, 42(10): 92-98. doi: 10.12259/j.issn.2095-610X.S20211044

Citation:

Lin WEI, Yu-ran FENG, Hui YUAN, Ke-yu ZHOU, Yi ZHAO, Jun QIAN, Mei ZHU. Comparison of Six Methods of Ultrasound-guided Fine-needle Aspiration Biopsy of Thyroid Nodules[J]. Journal of Kunming Medical University, 2021, 42(10): 92-98. doi: 10.12259/j.issn.2095-610X.S20211044

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Comparison of Six Methods of Ultrasound-guided Fine-needle Aspiration Biopsy of Thyroid Nodules

doi: 10.12259/j.issn.2095-610X.S20211044

Lin WEI¹,
Yu-ran FENG¹,
Hui YUAN¹,
Ke-yu ZHOU¹,
Yi ZHAO¹,
Jun QIAN^{2
,
,},
Mei ZHU^{1
,
,}

1.
Dept. of Ultrasound
2.
Dept. of Thyroid Surgery，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-08-10
Available Online: 2021-10-29
Publish Date: 2021-10-30

Abstract

Abstract

Objective To compare the accuracy of six operative methods of ultrasound-guided fine-needle aspiration biopsy of thyroid nodules and to share the experience of the operation. Methods The data of 1903 patients who underwent thyroid surgery, preoperative fine-needle biopsy （FNA） and definite pathological findings after surgery were included. The data of the above patients were divided into 6 groups: A1-A3, B1-B3 according to the angle of FNA needle insertion and sampling technique. category A for end-lateral and category B for side-lateral; category 1 for negative pressure aspiration, category 2 for normal pressure aspiration, and category 3 for closed pressure entry and exit. Based on the traditional evaluation indexes, the Bowker weighted test was used to compare their differences and the Kappa linear weighted test for consistency. The advantages and disadvantages of the six different operation methods were finally evaluated. Results Sensitivity: Category A was higher than category B. Highest in group A3; 96.47% and lowest in group B2; 87.69%; Specificity: all were 100%; Accuracy: category A was higher than category B subgroups, highest in group A3; 97.69%, and lowest in group B2; 91.20%;Positive prediction rate: all were 100%; Negative prediction rate: category A was higher than class B subgroups. The highest A3 was 95.65% in group A3, and the lowest was 78.57% in group B2;Yordon index: higher in category A than in category B. The highest was 96.47% in group A3 and the lowest was 87.69% in group B2. Bowker’ s weighted test results: the P -values were: A3 > A1 > A2 > B3 = B1 = B2.The P of A1, A2, B1, B2, and B3 < 0.01, statistically significantly different from postoperative histopathological results. The P -value of A3 was 0.072, P > 0.05. There was no statistical difference with the postoperative histopathological result in A3; Kappa consistency test （linear weighted） results: A3 > A1 > A2 > B3 > B1 > B2; The highest value was 0.959 for the A3 group, and the lowest was 0.821 for the B2 group. Conclusions Based on the traditional evaluation index, paired chi-square and Kappa test results, the end-lateral approach with closed-pressure entry and exit sampling method （A3 group） have the closest cytologic pathology results to postoperative histologic pathology and is the best FNA approach with high sampling quality.
- Ultrasound-guided,
- Fine-needle biopsy,
- Bowker weighted test,
- Kappa linear weighted test

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References(13)

References

[1]	霍立双,刘丰雨,高琛,等. 我国大陆地区甲状腺结节患病率Meta分析[J]. 河北医科大学学报,2017,38(2):138-141. doi: 10.3969/j.issn.1007-3205.2017.02.004
[2]	陈万青,李贺,孙可欣,等. 2014年中国恶性肿瘤发病和死亡分析[J]. 中华肿瘤杂志,2018,40(1):5-13.
[3]	Orloff L A,Wiseman S M,Bernet V J,et al. American Thyroid Association Statement on Postoperative Hypoparathyroidism:Diagnosis,Prevention,and Management in Adults[J]. Thyroid,2018,28(7):830-841. doi: 10.1089/thy.2017.0309
[4]	Haugen B R,Alexander E K,Bible K C,et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer:the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer[J]. Thyroid,2016,26(1):1-33. doi: 10.1089/thy.2015.0020
[5]	Filetti S,Durante C,Hartl D,et al. Thyroid cancer:ESMO Clinical Practice Guidelines for diagnosis,treatment and follow-up[J]. Ann Oncol,2019,30(12):1856-1883. doi: 10.1093/annonc/mdz400
[6]	Dorothy A, Shead M S, Erin Vidic M A, et al. National comprehensive Cancer Netwrok（NCCN） Guidelines For Patients: Thyroid Cancer Version. Online-Web, 2020.02.
[7]	上海市医学会超声医学分会介入学组,上海市社会医疗机构协会超声医学分会介入与重症超声专业委员会. 超声引导下甲状腺结节细针穿刺细胞学检查实践指南(2019版)[J]. 中华超声影像学杂志,2020,29(5):369-383. doi: 10.3760/cma.j.cn131148-20191107-00678
[8]	Ha E J,Na D G,Baek J H,et al. US fine-needle aspiration biopsy for thyroid malignancy:diagnostic performance of seven society guidelines applied to 2000 thyroid nodules[J]. Radiology,2018,287(3):893-900. doi: 10.1148/radiol.2018171074
[9]	Ha S M,Baek J H,Na D G,et al. Diagnostic performance of practice guidelines for thyroid nodules:thyroid nodule size versus biopsy rates[J]. Radiology,2019,291(1):92-99. doi: 10.1148/radiol.2019181723
[10]	Nguyen X V,Roy Choudhury K,Tessler F N,et al. Effect of tumor size on risk of metastatic disease and survival for thyroid cancer:implications for biopsy guidelines[J]. Thyroid,2018,28(3):295-300. doi: 10.1089/thy.2017.0526
[11]	Khatami F,Tavangar S M. Liquid biopsy in thyroid cancer:new insight[J]. International Journal of Hematology-oncology and Stem Cell Research,2018,12(3):235.
[12]	颜虹, 徐勇勇. 医学统计学[M]. 第3版. 北京: 人民卫生出版社, 2017: 16-19.
[13]	Fleiss J L,Cohen J. The Equivalence of Weighted Kappa and the Intraclass Correlation Coefficient As Measures of Reliability[J]. Educational & Psychological Measurement,2016,33(3):613-619.

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