Correlation between Cerebral Perfusion and Retinal Oxygenation Response of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Yu-xing XIONG; Jun TANG; Ru-yun LIN; Jia-min NIE; Min-jie ZHOU; Ju-wei SHAO

doi:10.12259/j.issn.2095-610X.S20211046

Volume 42 Issue 10

Oct. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(10): 76-83

Yu-xing XIONG, Jun TANG, Ru-yun LIN, Jia-min NIE, Min-jie ZHOU, Ju-wei SHAO. Correlation between Cerebral Perfusion and Retinal Oxygenation Response of Diabetic Retinopathy in Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2021, 42(10): 76-83. doi: 10.12259/j.issn.2095-610X.S20211046

Citation:

Yu-xing XIONG, Jun TANG, Ru-yun LIN, Jia-min NIE, Min-jie ZHOU, Ju-wei SHAO. Correlation between Cerebral Perfusion and Retinal Oxygenation Response of Diabetic Retinopathy in Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2021, 42(10): 76-83. doi: 10.12259/j.issn.2095-610X.S20211046

Citation:

Yu-xing XIONG, Jun TANG, Ru-yun LIN, Jia-min NIE, Min-jie ZHOU, Ju-wei SHAO. Correlation between Cerebral Perfusion and Retinal Oxygenation Response of Diabetic Retinopathy in Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2021, 42(10): 76-83. doi: 10.12259/j.issn.2095-610X.S20211046

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Correlation between Cerebral Perfusion and Retinal Oxygenation Response of Diabetic Retinopathy in Type 2 Diabetes Mellitus

doi: 10.12259/j.issn.2095-610X.S20211046

1.
The Endocrinology Department of the Affiliated Hospital of Yunnan University （The Second People Hospital of Yunnan Province），Kunming Yunnan 650021
2.
Community Healthcare Center of Chengjiang fenglu street，Chengjiang Yunnan 653100
3.
Quality Control Department of the Affiliated Hospital of Yunnan University （The Second People Hospital of Yunnan Province），Kunming Yunnan 650021
4.
The Radiology Department of the Affiliated Hospital of Yunnan University （The Second People Hospital of Yunnan Province），Kunming Yunnan 650021，China

Received Date: 2021-08-11
Publish Date: 2021-10-25

Abstract

Abstract

Objective To study MR cerebral perfusion and the retinal oxygenation response in patients with different stages of diabetic retinopathy without hypertension and normal control group, and to analyze the correlation between different cerebral perfusion parameters and retinal oxygenation response. Methods From June 2017 to December 2019, 34 patients with diagnosed type 2 diabetes mellitus （T2DM） and 21 healthy controls were enrolled in the Department of Endocrinology and ophthalmology department, the Affiliated Hospital of Yunnan University. T2DM patients were divided into proliferative stage of diabetic retinopathy （PDR） group and non-diabetic retinopathy （NDR） group according to ophthalmofundoscopy. All subjects with hypertension were excluded. Plain MR, magnetic resonance angiography （MRA）, dynamic susceptibility contrast-perfusion weighted imaging （DSC-PWI）, orbital 3D-spoiled GRASS （3D-SPGR） before and after oxygen uptake scans were performed. Continuous variables were analyzed by unpaired t-test. Pearson product moment correlation was performed between relative cerebral blood flow （rCBF） and variables of retinal delta PO_（2）（△P0₂） in bilateral temporal, nasal and optic disc of eyeballs of PDR and NDR group. Results rCBF of left inferior temporal gyrus and bilateral cingulate gyrus in PDR group was lower than that in NDR group and NC group （P < 0.05）. Relative cerebral blood volume （rCBV） of right inferior temporal gyrus, left occipital lobe and left cingulate gyrus in PDR group was lower than that in NDR group and NC group （ P < 0.05）, and the rCBV of right parahippocampal gyrus in PDR group was higher than that in NDR group and NC group （ P < 0.05）. The mean transit time （MTT） of left inferior temporal gyrus, left cerebellar hemisphere and bilateral middle frontal gyrus in PDR group was higher than that in NDR group and NC group （ P < 0.05）. The mean transit time of left parahippocampal gyrus and right pons in PDR group was lower than that in NDR group and NC group （ P < 0.05）. Time to peak （TTP） of left cerebellar hemisphere, bilateral middle frontal gyrus, left inferior temporal gyrus and right cingulate gyrus in PDR group was higher than that in NDR group and NC group （ P < 0.05）, and TTP of right pontine and right parahippocampal gyrus in PDR group was lower than that in NDR and NC group （ P < 0.05）. The difference of △ P0 ₂ in bilateral temporal, nasal and optic disc of eyeballs between PDR group, NDR group and NC group was statistically significant （P < 0.05）. rCBF of left inferior temporal gyrus and bilateral cingulate gyrus in PDR group and NDR group were correlated with △P0 ₂ of bilateral temporal, nasal and optic disc （P < 0.05）. Conclusions There was significant association between cerebral blood flow perfusion and the diabetic retinopathy （DR） severity in type 2 diabetes mellitus. MRI retinal oxygenation response can be used as an imaging marker of diabetic cerebral capillary disease.
- Type 2 Diabetes Mellitus,
- Diabetic retinopathy,
- Cerebral blood perfusion,
- Retinal oxygenation response

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References(33)

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