Clinical Significance of HPV in Oropharyngeal Squamous Cell Carcinoma

En-zi FENG; Deng-huan WANG; Ran ZHANG; Xing-yu YANG; Nan ZHANG; Jie YANG; Xi-fang WU

doi:10.12259/j.issn.2095-610X.S20211109

Volume 42 Issue 11

Nov. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(11): 51-56

En-zi FENG, Deng-huan WANG, Ran ZHANG, Xing-yu YANG, Nan ZHANG, Jie YANG, Xi-fang WU. Clinical Significance of HPV in Oropharyngeal Squamous Cell Carcinoma[J]. Journal of Kunming Medical University, 2021, 42(11): 51-56. doi: 10.12259/j.issn.2095-610X.S20211109

Citation:

En-zi FENG, Deng-huan WANG, Ran ZHANG, Xing-yu YANG, Nan ZHANG, Jie YANG, Xi-fang WU. Clinical Significance of HPV in Oropharyngeal Squamous Cell Carcinoma[J]. Journal of Kunming Medical University, 2021, 42(11): 51-56. doi: 10.12259/j.issn.2095-610X.S20211109

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Clinical Significance of HPV in Oropharyngeal Squamous Cell Carcinoma

doi: 10.12259/j.issn.2095-610X.S20211109

Dept. of Head and Neck Surgery，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2021-09-14
Available Online: 2021-11-15
Publish Date: 2021-11-30

Abstract

Abstract

Objective To explore the clinical significance of HPV in oropharyngeal squamous cell carcinoma. Methods A total of 129 patients who were diagnosed and treated in Yunnan Tumor Hospital and met the inclusion criteria in oropharyngeal cancer from January 2010 to December 2019 were selected as the research subjects. The collected pathological specimens were detected using HPV16/18 DNA probes and HPV 6/11 DNA probes. SPSS 24.0 statistical software was used for data analysis. Results The positive rate of HPV in this study was 39.53%, all of which were high-risk HPV 16/18 infection. The positive rate was highest in tonsil area and tongue root area. The number of cases with the onset age less than 60 years （P = 0.041） and the early stage （P = 0.001） in the HPV positive group was significantly higher than that in the negative group. The number of long-term smoking cases in the negative group was significantly higher than that in the positive group （P = 0.012）. The treatment effective rate of patients in the HPV positive group is higher than that in the HPV negative group. Conclusion Compared with HPV-negative oropharyngeal squamous cell carcinoma, patients with HPV-positive oropharyngeal squamous cell carcinoma have a younger onset, early stage, fewer long-term smokers, and are more sensitive to radiotherapy and chemotherapy.
- Oropharyngeal tumor,
- Squamous cell carcinoma,
- Human papillomavirus

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References(25)

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