Characteristics of Infection Indexes in Patients with Antituberculous Drug-induced Liver Injury

Ni-hong LU; Hong-lu LIU; Yang-jun CHEN; Yan YANG; Yong-rui YANG; Ying-rong DU

doi:10.12259/j.issn.2095-610X.S20211111

Volume 42 Issue 11

Nov. 2021

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Ni-hong LU, Hong-lu LIU, Yang-jun CHEN, Yan YANG, Yong-rui YANG, Ying-rong DU. Characteristics of Infection Indexes in Patients with Antituberculous Drug-induced Liver Injury[J]. Journal of Kunming Medical University, 2021, 42(11): 57-61. doi: 10.12259/j.issn.2095-610X.S20211111

Citation:

Ni-hong LU, Hong-lu LIU, Yang-jun CHEN, Yan YANG, Yong-rui YANG, Ying-rong DU. Characteristics of Infection Indexes in Patients with Antituberculous Drug-induced Liver Injury[J]. Journal of Kunming Medical University, 2021, 42(11): 57-61. doi: 10.12259/j.issn.2095-610X.S20211111

Citation:

Ni-hong LU, Hong-lu LIU, Yang-jun CHEN, Yan YANG, Yong-rui YANG, Ying-rong DU. Characteristics of Infection Indexes in Patients with Antituberculous Drug-induced Liver Injury[J]. Journal of Kunming Medical University, 2021, 42(11): 57-61. doi: 10.12259/j.issn.2095-610X.S20211111

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Characteristics of Infection Indexes in Patients with Antituberculous Drug-induced Liver Injury

doi: 10.12259/j.issn.2095-610X.S20211111

1.
Dept. of Respiratory and Critical Care Medicine
2.
Dept. of Infectious Diseases，The Third People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2021-09-24
Available Online: 2021-11-15
Publish Date: 2021-11-30

Abstract

Abstract

Objective To retrospectively analyze the characteristics of infection indicators of antituberculosis drug-related liver injury in patients with pulmonary tuberculosis combined with HIV versus those with pulmonary tuberculosis alone, and to assess clinical risk factors and correlations. Methods Patients with liver injury induced by antituberculosis drugs were collected, including 55 cases of pulmonary tuberculosis and 39 cases of pulmonary tuberculosis combined with HIV infection. Clinical data were recorded, fasting venous blood was collected, CD3+, CD4+ and CD8+ T cell ratios were detected by flow cytometry, and serum PCT, IL-6, CRP, SAA and ESR were detected by ELISA. Results There were no significant differences in age, gender composition, height, weight and body mass index between the two groups, and the immune function of the two groups were compared, the expression of CD4+ T lymphocytes and CD4%, CD CD4/CD8% were statistically different （P < 0.05）. The levels of CRP and SAA in inflammatory indexes were higher in patients with single pulmonary tuberculosis （P < 0.05）, and the degree of liver injury in patients with TB and HIV was lower than in the group of patients with TB alone, suggesting that the diseased population with normal immune function, which has a strong inflammatory response, is one of the risk factors leading to liver injury in the treatment of anti-tuberculosis drugs. Also this study showed that SAA was strongly correlated with the severity of liver injury in the tuberculosis group with anti-tuberculosis drug liver injury and the results were statistically significant （P < 0.05）. In the pulmonary TB with HIV infection group, IL-6 was closely associated with the severity of liver injury and the results were statistically significant （P < 0.05）. Conclusions Infection indicators are expressed differently in anti-tuberculosis drug liver injury with different types of patients. The increase of SAA and IL-6 is related to the severity of anti-tuberculosis drug liver injury in different types of patients.
- Infection indicators,
- Antituberculosis drug liver injury,
- Correlation analysis analysis

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