Relationship between Calcitonin Receptor，Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area

Ling NIU; Bo-yi LI; Cheng ZHANG; Rong MA; Yan TANG; Fang LIU; Li-min YIN; Zhu-jun HAN; Cui-juan MIAO; Xian ZHANG

doi:10.12259/j.issn.2095-610X.S20211114

Volume 42 Issue 11

Nov. 2021

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Ling NIU, Bo-yi LI, Cheng ZHANG, Rong MA, Yan TANG, Fang LIU, Li-min YIN, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG. Relationship between Calcitonin Receptor，Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area[J]. Journal of Kunming Medical University, 2021, 42(11): 74-80. doi: 10.12259/j.issn.2095-610X.S20211114

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Relationship between Calcitonin Receptor，Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area

doi: 10.12259/j.issn.2095-610X.S20211114

1.
Dept. of Endocrinology
2.
Dept. of Clinical Laboratory，First People’s Hospital of Kunmig，Kunming Yunnan 650011，China

Received Date: 2021-10-14
Available Online: 2021-11-15
Publish Date: 2021-11-30

Abstract

Abstract

Objective To study the relationship between calcitonin receptor （CTR）, vitamin D dreceptor （VDR） gene polymorphism and type 2 diabetesmellitus （T2DM） with osteoporosis in kunming area, and to explore the pathogenesis of T2DM with osteoporosis genetic susceptibility factors. Methods We selected 237 diabetic patients in the department of endocrinology of First People’ s hospital of Kunming from 2017 to 2019. （1） The enrolled patients were divided into T2DM without osteoporosis group （61 cases） , T2DM with osteopenia group （111 cases）, and T2DM with osteoporosis group （65 cases） by bone mineral density results. PCR - RFLP technique was used to test CTR and VDR genotypes, and the differences between the three groups of patients were compared in following indicators: CTR and VDR genotype and allele frequency, sex, age, duration of diabetes, blood pressure, height, weight, body mass index （BMI）, fasting plasma glucose （FPG）, glycosylated hemoglobin （HbA1c）, blood calcium, blood lipids, blood uric acid （UA）, the concentration of vitamin D, estrogen and testosterone levels, allergic C - reactive protein （Hs – CRP）, fibrinogen （FIB）, oral glucose tolerance （OGTT） – 0 h, 2 h; 0 h, 2 h-insulin （INS） level and insulin resistance index （HOMA-IR）. （2） The differences in the bone mineral density were compared between patients with CTR joint VDR of different genotype combinations. （3）Multiariable logistic regression analysis was performed on the indicators with statistically significant difference in CTR joint VDR genotype combinations. Results （1） Three groups of patients were compared, CTR system joint VDR had no statistically significant difference in the different genotype combinations （P > 0.05）. （2） Comparison of three genotype combination in CTR system joint VDR, the bone mineral density has no statistical significant difference （P > 0.05）. （3） Multi-factor logistic regression analysis showed that age entered the regression equation of system and CTR system joint VDR genotype combinations did not enter the regression equation. Conclusions （1） Age is an independent risk factor in the kunming area of T2DM patients with osteoporosis. （2）CTR system joint VDR genotype combinations has nothing to do with the genetic susceptibility to T2DM with osteoporosis in kunming area .
- Calcitonin receptor,
- Vitamin D receptor,
- Gene polymorphism,
- Type 2 diabetes mellitus,
- Osteoporosis

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