Risk Factors and Early Clinical Characteristics of Neonatal Necrotizing Enterocolitis

Jing WANG; Lian-fang TANG; Mei-qun GU; Xiao-yan XU; Jian-hua YU; Shan HE; Zi-wei LI; Kai BI; Li-qiao LIU; Qiong ZHAO; Hong-ying MI

doi:10.12259/j.issn.2095-610X.S20211118

Volume 42 Issue 11

Nov. 2021

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Guixuan ZHANG, Xin SHI, Wei LI, Shuhua YE. Research Progress of Radiomics in Adrenal Tumors[J]. Journal of Kunming Medical University, 2022, 43(3): 142-147. doi: 10.12259/j.issn.2095-610X.S20220324

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Jing WANG, Lian-fang TANG, Mei-qun GU, Xiao-yan XU, Jian-hua YU, Shan HE, Zi-wei LI, Kai BI, Li-qiao LIU, Qiong ZHAO, Hong-ying MI. Risk Factors and Early Clinical Characteristics of Neonatal Necrotizing Enterocolitis[J]. Journal of Kunming Medical University, 2021, 42(11): 99-104. doi: 10.12259/j.issn.2095-610X.S20211118

Guixuan ZHANG, Xin SHI, Wei LI, Shuhua YE. Research Progress of Radiomics in Adrenal Tumors[J]. Journal of Kunming Medical University, 2022, 43(3): 142-147. doi: 10.12259/j.issn.2095-610X.S20220324

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Risk Factors and Early Clinical Characteristics of Neonatal Necrotizing Enterocolitis

doi: 10.12259/j.issn.2095-610X.S20211118

1.
School of Clinical Medicine Dali University，Dali Yunnan 671003
2.
Dept. of Pediatrics，First People’s Hospital of Yunnan Province，Kunming Yunnan 650032，China

Received Date: 2021-09-09
Publish Date: 2021-11-25

Abstract

Abstract

Objective To explore the risk factors and early clinical characteristics of neonatal necrotizing enterocolitis （NEC）, so as to improve the early warning of NEC and early intervention, so as to improve the prognosis of NEC. Methods A total of 95 children diagnosed with NEC in our NICU from November 22, 2017 to November 22, 2020 were collected, and 95 non-NEC children in the same period were selected as the control group according to the 1∶1 matching ratio. The univariate variables were screened by χ² test, and then multivariate Logistic regression analysis was performed. The count data were analyzed by t test and rank sum test, and the rank data were analyzed by Spearman rank correlation test, α= 0.05. Results It suggested that premature birth, low birth weight, infection and mechanical ventilation were independent risk factors for NEC, and abdominal distention and gastric retention were the main clinical manifestations in the early stage. There was no significant correlation between leukocytes and neutrophils and the severity of NEC, while C-Reactive Protein and procalcitonin were positively correlated with the severity of NEC. Lymphocytes and platelets were negatively correlated with the severity of the disease, （P < 0.05 ）. Abdominal orthostatic X-ray had no obvious specificity for the early diagnosis of NEC. Conclusion When the children have the premature birth, low birth weight, infection and mechanical ventilation risk factors, abdominal distension and poor feeding performance, accompanied by the increase of C-reactive protein and procalcitonin, it is necessary to be alert to the occurrence of NEC, and dynamic abdominal orthostatic X-ray and abdominal ultrasound can be performed to improve the early diagnosis rate.
- Necrotizing enterocolitis,
- Neonate,
- Risk factors,
- Clinical characteristics

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References

[1]	Lim J C,Golden J M,Ford H R. Pathogenesis of neonatal necrotizing enterocolitis[J]. Pediatr Surg Int,2015,31(6):509-518. doi: 10.1007/s00383-015-3697-9
[2]	Isani M A,Delaplain P T,Grishin A,et al. Evolving understanding of neonatal necrotizing enterocolitis[J]. Current Opinion in Pediatrics,2018,30(3):417-423. doi: 10.1097/MOP.0000000000000629
[3]	Pammi M,De Plaen I G,Maheshwari A. Recent advances in necrotizing enterocolitis research:Strategies for implementation in clinical practice[J]. Clin Perinatol,2020,47(2):383-397. doi: 10.1016/j.clp.2020.02.011
[4]	Chaaban H,Markel T A,Canvasser J,et al. Biobanking for necrotizing enterocolitis:Needs and standards[J]. J Pediatr Surg,2020,55(7):1276-1279. doi: 10.1016/j.jpedsurg.2019.05.002
[5]	Nolan L S,Wynn J L,Good M. Exploring clinically-Relevant experimental models of neonatal shock and necrotizing enterocolitis[J]. Shock,2020,53(5):596-604.
[6]	邵肖梅, 叶鸿瑁, 丘小汕 . 实用新生儿学[M]. 第5版 , 北京: 人民卫生出版社 , 2019: 633-634.
[7]	杨雪利,何刚,田鹏,刘娟. Ⅰ-FABP对坏死性小肠结肠炎的早期诊断及预后预测的价值研究[J]. 四川医学,2021,42(4):404-408.
[8]	Nguyen D N,Sangild P T. Pathogenesis and biomarkers for necrotizing enterocolitis:Getting any closer?[J]. EBioMedicine,2019,45(45):13-14.
[9]	Pasquier J C,Claris O,Rabilloud M,et al. Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks' gestation:A multicentre randomized controlled trial (MICADO STUDY)[J]. Eur J Obstet Gynecol Reprod Biol,2019,233(233):30-37.
[10]	Knell J,Han S M,Jaksic T,et al. Current status of necrotizing enterocolitis[J]. Curr Probl Surg,2019,56(1):11-38. doi: 10.1067/j.cpsurg.2018.11.005
[11]	Lin H,Mao S,Shi L,et al. Clinical characteristic comparison of low birth weight and very low birth weight preterm infants with neonatal necrotizing enterocolitis:a single tertiary center experience from eastern china[J]. Pediatr Surg Int,2018,34(11):1201-1207. doi: 10.1007/s00383-018-4339-9
[12]	Sun J,Marwah G,Westgarth M,et al. Effects of probiotics on necrotizing enterocolitis,sepsis,intraventricular hemorrhage,mortality,length of hospital stay,and weight gain in very preterm Infants:a meta-analysis[J]. Adv Nutr,2017,8(5):749-763. doi: 10.3945/an.116.014605
[13]	Rose A T,Patel R M. A critical analysis of risk factors for necrotizing enterocolitis[J]. Semin Fetal Neonatal Med,2018,23(6):374-379. doi: 10.1016/j.siny.2018.07.005
[14]	Hartman H A,Pennell C,Aronoff S,et al. Effect of feeding strategies on the development of fulminant necrotizing enterocolitis[J]. Eur J Pediatr Surg,2021,31(1):49-53. doi: 10.1055/s-0040-1715613
[15]	黄兰,熊涛,唐军,等. 新生儿坏死性小肠结肠炎临床诊疗指南(2020)[J]. 中国当代儿科杂志,2021,23(1):1-11. doi: 10.7499/j.issn.1008-8830.2011145
[16]	Hackam D J,Sodhi C P,Good M. New insights into necrotizing enterocolitis:from laboratory observation to personalized prevention and treatment[J]. J Pediatr Surg,2019,54(3):398-404. doi: 10.1016/j.jpedsurg.2018.06.012
[17]	Zhang B,Xiu W,Dai Y,et al. Protective effects of different doses of human milk on neonatal necrotizing enterocolitis[J]. Medicine (Baltimore),2020,99(37):e22166.
[18]	Shah S D,Booth N,Nandula P,et al. Effects of standardized feeding protocol on growth velocity and necrotizing enterocolitis in extremely low birth weight infants[J]. J Perinatol,2021,41(1):134-139. doi: 10.1038/s41372-020-00892-9
[19]	Quigley M,Embleton N D,McGuire W. Formula versus donor breast milk for feeding preterm or low birth weight infants[J]. Cochrane Database Syst Rev,2018,6(6):CD002971.
[20]	Wang L,Ni S W,Zhu K R,et al. Changes in c-reactive protein and procalcitonin levels in neonates with necrotizing enterocolitis and their clinical significance[J]. Zhongguo Dang Dai Er Ke Za Zhi,2018,20(10):825-830.
[21]	Zierk J,Hirschmann J,Toddenroth D,et al. Next-generation reference intervals for pediatric hematology[J]. Clin Chem Lab Med,2019,57(10):1595-1607. doi: 10.1515/cclm-2018-1236
[22]	新生儿败血症诊断及治疗专家共识（2019年版）[J]. 中华儿科杂志, 2019, 57（4）: 252-257.
[23]	Neu J. Necrotizing enterocolitis:The future[J]. Neonatology,2020,117(2):240-244. doi: 10.1159/000506866
[24]	van Druten J,Khashu M,Chan S S,et al. Abdominal ultrasound should become part of standard care for early diagnosis and management of necrotising enterocolitis:a narrative review[J]. Arch Dis Child Fetal Neonatal Ed,2019,104(5):F551-F559. doi: 10.1136/archdischild-2018-316263
[25]	Chen S,Hu Y,Liu Q,et al. Application of abdominal sonography in diagnosis of infants with necrotizing enterocolitis[J]. Medicine (Baltimore),2019,98(28):e16202.
[26]	Kim J H. Role of abdominal us in diagnosis of NEC[J]. Clin Perinatol,2019,46(1):119-127. doi: 10.1016/j.clp.2018.10.006

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