Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation

Zhong FANG; Xiao-dong XU; Li-hua WANG; Ying ZHANG; Chao MA

doi:10.12259/j.issn.2095-610X.S20211120

Volume 42 Issue 11

Nov. 2021

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Zhong FANG, Xiao-dong XU, Li-hua WANG, Ying ZHANG, Chao MA. Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation[J]. Journal of Kunming Medical University, 2021, 42(11): 111-116. doi: 10.12259/j.issn.2095-610X.S20211120

Citation:

Zhong FANG, Xiao-dong XU, Li-hua WANG, Ying ZHANG, Chao MA. Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation[J]. Journal of Kunming Medical University, 2021, 42(11): 111-116. doi: 10.12259/j.issn.2095-610X.S20211120

Citation:

Zhong FANG, Xiao-dong XU, Li-hua WANG, Ying ZHANG, Chao MA. Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation[J]. Journal of Kunming Medical University, 2021, 42(11): 111-116. doi: 10.12259/j.issn.2095-610X.S20211120

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Prognostic Value of eGFR and NT-proBNP in Patients with Chronic Heart Failure Complicated with Atrial Fibrillation

doi: 10.12259/j.issn.2095-610X.S20211120

Dept. of Cardiology，The People’s Hospital of Chizhou，Chizhou Anhui 247000，China

Received Date: 2021-09-07
Available Online: 2021-11-16
Publish Date: 2021-11-30

Abstract

Abstract

Objective To investigate the prognostic value of eGFR and serum NT-proBNP in patients with chronic heart failure complicated with atrial fibrillation. Methods From January 2018 to December 2019, 139 hospitalized patients with chronic heart failure complicated with atrial fibrillation were selected. The serum creatinine and NT-proBNP of the patients were measured, and the estimated glomerular filtration rate （eGFR） of the patients was calculated according to theequationofModification of Diet in Renal Disease. All-cause deaths after discharge were followed up. Logistic regression was used to analyze the risk factors of all-cause death in chronic heart failure complicated with atrial fibrillation during the follow-up period. ROC curve was used to analyze the prognostic value of eGFR and serum NT-proBNP in patients with chronic heart failure complicated with atrial fibrillation.Kaplan-meier method was used to draw the survival curve, and log-rank test was used for survival analysis. Results During the follow-up, 65 patients were found dead. The incidence was 46.76%. The area under the curve of eGFR-in predicting the absence of all-cause death in patients with chronic heart failure and atrial fibrillation was 0.651 （95%CI: 0.562 ～ 0.740）.The sensitivity was 57.70%, and the specificity was 69.20%. The area under the curve of serum NT-proBNP for predicting all-cause death in patients with chronic heart failure complicated with atrial fibrillation was 0.720 （95%CI: 0.638 ～ 0.803）.The sensitivity was 69.20%, and the specificity was 67.30%. The cumulative survival rate of patients in the low-eGFR group was significantly lower than that in the high-eGFR group during follow-up. The Log-rank value was 9.21, P = 0.002. During the follow-up, the cumulative survival rate of patients in the high level of NT-proBNP group was significantly lower than that in the low level of NT-proBNP group. The statistical value of Log-rank test was 16.91, P < 0.001. Conclusion eGFR and serum NT-proBNP have certain predictive value for the short-term prognosis of patients with chronic heart failure complicated with atrial fibrillation.
- Chronicheart failure,
- Atrial fibrillation,
- Evaluate glomerular filtration rate,
- N-terminal probrain natriuretic peptide,
- Prognosis

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References(24)

References

[1]	Carlisle M A,Fudim M,DeVore A D,et al. Heart failure and atrial fibrillation,like fire and fury[J]. JACC Heart Fail,2019,7(6):447-456. doi: 10.1016/j.jchf.2019.03.005
[2]	徐永玄,杨萍,郭涛. 房颤发生机制及治疗新进展[J]. 昆明医科大学学报,2019,40(5):135-138. doi: 10.3969/j.issn.1003-4706.2019.05.026
[3]	莘琳琳,李禹龙,袁慧. 心力衰竭相关标志物研究进展[J]. 医学研究杂志,2021,50(2):5-8.
[4]	李俊贤,林娅,赵新艳,等. 血浆NT-proBNP水平在慢性心衰中的诊断及预后评估[J]. 中国实用医药,2020,15(22):8-10.
[5]	湛勇,王爽. 血清胱抑素C及NT-proBNP 与慢性心力衰竭患者疾病严重程度及预后相关性研究[J]. 医学理论与实践,2020,33(2):173-175.
[6]	李雨濛,胡元会,商秀洋,等. 不同肾功能评价指标对慢性心力衰竭患者远期预后的预测价值[J]. 中国循证心血管医学杂志,2020,12(7):816-819. doi: 10.3969/j.issn.1674-4055.2020.07.10
[7]	Raman M,Middleton R J,Kalra P A,et al. Estimating renal function in old people:an in-depth review[J]. Int Urol Nephrol,2017,49(11):1979-1988. doi: 10.1007/s11255-017-1682-z
[8]	全国eGFR课题协作组. MDRD方程在我国慢性肾脏病患者中的改良和评估[J]. 中华肾脏病杂志,2006,22(10):589-595. doi: 10.3760/j.issn:1001-7097.2006.10.002
[9]	赵金芳,田艳珍. 老年慢性心力衰竭患者氨基末端脑利钠肽前体、甲状腺激素水平变化及其对病情、预后的影响[J]. 临床误诊误治,2020,33(9):54-58. doi: 10.3969/j.issn.1002-3429.2020.09.013
[10]	郭洪森. 老年人慢性心力衰竭并发肾功能不全临床特征及预后研究[J]. 中外医疗,2021,40(6):26-28.
[11]	安英男,唐敏,赵丽君. 血清胱抑素C和N末端脑钠肽前体与慢性心力衰竭患者疾病严重程度及预后的相关性分析[J]. 解放军医药杂志,2019,31(5):71-74. doi: 10.3969/j.issn.2095-140X.2019.05.017
[12]	Hunt S A,Abraham W T,Chin M H,et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult:a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure):developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation:endorsed by the Heart Rhythm Society[J]. Circulation,2005,112(12):e154-235.
[13]	中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2014[J]. 中华心血管病杂志,2014,42(2):98-122.
[14]	Kirchhof P,Benussi S,Kotecha D,et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS[J]. Eur Heart J,2016,37(38):2893-2962. doi: 10.1093/eurheartj/ehw210
[15]	Sartipy U,Dahlström U,Fu M,et al. Atrial fibrillation in heart failure with preserved,mid-range,and reduced ejection fraction[J]. JACC Heart Fail,2017,5(8):565-574. doi: 10.1016/j.jchf.2017.05.001
[16]	van Veldhuisen D J,Aass H,El Allaf D,et al. Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MERIT-HF Study[J]. Eur J Heart Fail,2006,8(5):539-546.
[17]	Crijns H J,Tjeerdsma G,de Kam P J,et al. Prognostic value of the presence and development of atrial fibrillation in patients with advanced chronic heart failure[J]. Eur Heart J,2000,21(15):1238-1245.
[18]	Morin D P,Bernard M L,Madias C,et al. The state of the art:atrial fibrillation epidemiology,prevention,and treatment[J]. Mayo Clin Proc,2016,91(12):1778-1810. doi: 10.1016/j.mayocp.2016.08.022
[19]	吴超,赵雪燕,袁晋青,等. NT-proANP、NT-proBNP和NT-proCNP对心力衰竭患者心源性事件预后预测价值的比较[J]. 中国分子心脏病学杂志,2021,21(3):3949-3952.
[20]	Yilmaz M B,Zorlu A,Bektaşoğlu G,et al. The product of eGFR and hemoglobin may help predict mortality in systolic heart failure patients without severe anemia and renal failure[J]. Turk Kardiyol Dern Ars,2012,40(1):9-15. doi: 10.5543/tkda.2012.01496
[21]	汪芸,王如兴. NT-proBNP联合肾小球滤过率对慢性心功能不全患者心衰程度的预测价值[J]. 江苏大学学报:医学版,2020,30(2):173-176.
[22]	刘妮妮,张健. 射血分数降低和保留的心衰患者中房颤与NT-proBNP/BNP的关系[J]. 中国分子心脏病学杂志,2018,18(4):2559-2563.
[23]	孙礼玲,周伟,刘子龙,等. NT-proBNP与阵发性房颤发生的相关性研究[J]. 临床医药文献杂志,2019,6(20):21-24.
[24]	Hijazi Z,Wallentin L,Siegbahn A,et al. N-terminal pro-B-type natriuretic peptide for risk assessment in patients with atrial fibrillation:insights from the ARISTOTLE Trial (Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation)[J]. J Am Coll Cardiol,2013,61(22):2274-2284. doi: 10.1016/j.jacc.2012.11.082

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