Effect of Tenofovir Combined with Ganshuang Granule on Hemodynamics of Portal Vein System in Hepatitis B Liver Cirrhosis

Li LIU; Jun-yi LI; Chun-yun LIU; Ying-rong DU; Jian-peng GAO; Hui-ming LI; Wei-kun LI; Yan-wei QI; Hui WANG

doi:10.12259/j.issn.2095-610X.S20211125

Volume 42 Issue 11

Nov. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(11): 134-139

Li LIU, Jun-yi LI, Chun-yun LIU, Ying-rong DU, Jian-peng GAO, Hui-ming LI, Wei-kun LI, Yan-wei QI, Hui WANG. Effect of Tenofovir Combined with Ganshuang Granule on Hemodynamics of Portal Vein System in Hepatitis B Liver Cirrhosis[J]. Journal of Kunming Medical University, 2021, 42(11): 134-139. doi: 10.12259/j.issn.2095-610X.S20211125

Citation:

Li LIU, Jun-yi LI, Chun-yun LIU, Ying-rong DU, Jian-peng GAO, Hui-ming LI, Wei-kun LI, Yan-wei QI, Hui WANG. Effect of Tenofovir Combined with Ganshuang Granule on Hemodynamics of Portal Vein System in Hepatitis B Liver Cirrhosis[J]. Journal of Kunming Medical University, 2021, 42(11): 134-139. doi: 10.12259/j.issn.2095-610X.S20211125

Citation:

Li LIU, Jun-yi LI, Chun-yun LIU, Ying-rong DU, Jian-peng GAO, Hui-ming LI, Wei-kun LI, Yan-wei QI, Hui WANG. Effect of Tenofovir Combined with Ganshuang Granule on Hemodynamics of Portal Vein System in Hepatitis B Liver Cirrhosis[J]. Journal of Kunming Medical University, 2021, 42(11): 134-139. doi: 10.12259/j.issn.2095-610X.S20211125

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Effect of Tenofovir Combined with Ganshuang Granule on Hemodynamics of Portal Vein System in Hepatitis B Liver Cirrhosis

doi: 10.12259/j.issn.2095-610X.S20211125

Dept. of Infectious Disease，The Third People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2021-09-25
Available Online: 2021-11-16
Publish Date: 2021-11-30

Abstract

Abstract

Objective To investigate the effect of tenofovirdipivoxil combined with Ganshuang granules on hemodynamics of portal venous system in hepatitis B liver cirrhosis. Methods 180 patients with hepatitis B cirrhosis were randomly divided into three groups: 60 cases in tenofovir disoproxil fumarate combined with Ganshuang granule group （group A）, 60 cases in tenofovir disoproxil fumarate combined with Compound Biejia Ruangan Tablet group （group B） and 60 cases in tenofovir disoproxil fumarate alone group （Group C）, treatment 6 Months. Before and after treatment, we collected the gender, age, blood biochemical indexes, liver stiffness, hemodynamic indexes of portal vein system, portal vein diameter （DPV）, portal vein mean blood flow velocity （VPV）, splenic vein diameter （Dsv）, spleen Mean venous blood flow velocity （Vsv）, portal vein blood flow （Qpv）, splenic vein blood flow （Qsv）, etc. Results The blood biochemical indexes, hemodynamic indexes and liver hardness of the three groups were significantly improved after treatment. After treatment, the recovery of blood biochemical indexes, liver hardness and hemodynamic indexes in group A and B were better than those in group C （P < 0.05）; After treatment, compared with group B, ALT and AST decreased, liver hardness decreased, and some portal hemodynamic indexes （DPV, VPV, qpv） recovered better in group A than in group B. Conclusions Tenofovir disoproxil fumarate combined with Ganshuang granule could better improve the liver function, fibrosis and hemodynamic indexes of portal vein system in hepatitis B cirrhosis. The curative effect is significantly better than that of tenofovir disoproxil fumarate alone or combined with Compound Biejia Ruangan Tablet.
- Tenofovir disproxil fumarate,
- Ganshuang granules,
- Hepatitis B cirrhosis,
- Hemodynamics

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References(22)

References

[1]	中华医学会肝病学分会,中华医学会感染病学分会. 慢性乙型肝炎防治指南(2015更新版)[J]. 中华肝脏病杂志,2015,23(12):888-905. doi: 10.3760/cma.j.issn.1007-3418.2015.12.002
[2]	梁晋川,谭正怀. 乙肝性肝纤维化发病机理研究进展[J]. 西南军医,2019,21(1):41-44. doi: 10.3969/j.issn.1672-7193.2019.01.012
[3]	程贤文,稂慧芳,黄灵跃,等. 复方鳖甲软肝片对乙肝肝硬化患者PD/PVa比值、Fibroscan和eGFR的影响[J]. 云南中医学院学报,2016,39(5):74-77,89.
[4]	张世应,张书勤. 复方鳖甲软肝片联合恩替卡韦治疗HBeAg阴性乙型肝炎肝纤维化疗效及对血清炎性因子的影响[J]. 中国药业,2017,26(18):75-77. doi: 10.3969/j.issn.1006-4931.2017.18.028
[5]	张耀武. 恩替卡韦分散片联合肝爽颗粒治疗失代偿期乙型肝炎肝硬化患者临床观察[J]. 实用肝脏病杂志,2013,16(6):550-551. doi: 10.3969/j.issn.1672-5069.2013.06.026
[6]	Forman L M,Lucey M R. Predicting the prognosis of chronic liver disease:an evolution from child to M ELD,Mayo End—stage Liver Disease[J]. Hepatology,2001,33(2):473-475. doi: 10.1053/jhep.2001.22481
[7]	中华医学会肝病学分会,中华医学会感染病学分会. 慢性乙型肝炎防治指南(2015更新版)[J]. 中华传染病杂志,2015,33(11):641-662. doi: 10.3760/cma.j.issn.1000-6680.2015.11.001
[8]	Mittal P,Gupta R,Mittal G,et a1. Association between portal vein color Doppler findings and the severity of disease in cirrhotic patients with portal hypertension[J]. Iran J Radiol,2011,8(4):211-217.
[9]	Ziol M,Handra Luca A,Kettaneh A,el a1. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis c[J]. Hepatology,2005,41(1):48-54. doi: 10.1002/hep.20506
[10]	郑磊,罗蒙. 肝硬化门静脉高压症的基础研究进展[J]. 肝胆胰外科杂志,2019,31(4):254-257.
[11]	李柏胜,肖颖,钱方兴,等. 乙型肝炎肝硬化患者血清KLF2和TNFSF15表达与门静脉血流动力学相关性研究[J]. 肝脏,2018,23(4):310-311. doi: 10.3969/j.issn.1008-1704.2018.04.011
[12]	Chon Y E,Park J Y,Myoung S M,et al. Improvement of liver fibrosis after long-term antiviral therapy assessed by fibroscan in chronic hepatitis B patients with advanced fibrosis[J]. Am J Gastroenterol,2017,112(6):882-891.
[13]	Soker G,BahadirOzturk A,Gulek B,et al. Doppler ultrasonography helps discriminate between cirrhotic and non-cirrhotic patients with viral B and C hepatitis[J]. Diagn Interv Imaging,2016,97(3):339-345.
[14]	孟洪宇, 常虹. 黄芩水煎液及黄芩苷抗大鼠肝纤维化药效作用比较研究 [ J]. 世界中医药, 2018, 13 （3）: 699 - 702.
[15]	黄小梅, 郭莉娜, 李灿, 等. 锁阳通过抑制炎症因子的表达对抗 CCL 4 导致的小鼠肝纤维化 [ J]. 成都医学院学报, 2018, 13 （3）: 249 - 252, 261.
[16]	高建蓉,陶君,张赤志,等. 鳖甲防治肝纤维化实验研究[J]. 中华中医药学刊,2008,26(11):2462-2471.
[17]	马红,王宝恩,陈翌阳,等. 黄芪对肝纤维化治疗作用的实验研究[J]. 中华肝脏病杂志,1997,5(1):32-33.
[18]	汪巍, 王丽娜, 许枬, 等. 柴胡与醋柴胡抗大鼠免疫损伤性肝纤维化作用比较研究 [ J]. 中成药, 2014, 36 （4）: 828 - 830.
[19]	尚双艳, 高翔. 香附多糖对牛血清白蛋白诱导的肝纤维化大鼠血清 MMP - 2、 TIMP - 2 和 TGF - β1 水平的影响 [ J ]. 实用肝脏病杂志, 2018, 21 （ 1 ）: 42 - 45.
[20]	刘峰,党海霞,马久太. 肝爽颗粒对大鼠实验性肝纤维化的影响[J]. 中西医结合肝病杂志,2005,15(5):286-287. doi: 10.3969/j.issn.1005-0264.2005.05.012
[21]	岳兰萍,马红,贾继东. 肝爽颗粒对HSC—T6细胞Col I、ColIH、TIMPl基因及蛋白表达的影响[J]. 中西医结合肝病杂志,2007,17(2):85.87,91.
[22]	Liu Y M,Shi H B,Liu Y R,et al. Protective effect of ganshuang granules on liver cirrhosis by suppressing regulatory T cells in mouse model[J]. Chin J Integr Med,2019,25(1):51-58. doi: 10.1007/s11655-015-2430-9

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