Effect of Tenofovir Combined with Ganshuang Granule on Hemodynamics of Portal Vein System in Hepatitis B Liver Cirrhosis

Li LIU; Jun-yi LI; Chun-yun LIU; Ying-rong DU; Jian-peng GAO; Hui-ming LI; Wei-kun LI; Yan-wei QI; Hui WANG

doi:10.12259/j.issn.2095-610X.S20211125

Volume 42 Issue 11

Nov. 2021

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Li LIU, Jun-yi LI, Chun-yun LIU, Ying-rong DU, Jian-peng GAO, Hui-ming LI, Wei-kun LI, Yan-wei QI, Hui WANG. Effect of Tenofovir Combined with Ganshuang Granule on Hemodynamics of Portal Vein System in Hepatitis B Liver Cirrhosis[J]. Journal of Kunming Medical University, 2021, 42(11): 134-139. doi: 10.12259/j.issn.2095-610X.S20211125

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Effect of Tenofovir Combined with Ganshuang Granule on Hemodynamics of Portal Vein System in Hepatitis B Liver Cirrhosis

doi: 10.12259/j.issn.2095-610X.S20211125

Dept. of Infectious Disease，The Third People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2021-09-25
Available Online: 2021-11-16
Publish Date: 2021-11-30

Abstract

Abstract

Objective To investigate the effect of tenofovirdipivoxil combined with Ganshuang granules on hemodynamics of portal venous system in hepatitis B liver cirrhosis. Methods 180 patients with hepatitis B cirrhosis were randomly divided into three groups: 60 cases in tenofovir disoproxil fumarate combined with Ganshuang granule group （group A）, 60 cases in tenofovir disoproxil fumarate combined with Compound Biejia Ruangan Tablet group （group B） and 60 cases in tenofovir disoproxil fumarate alone group （Group C）, treatment 6 Months. Before and after treatment, we collected the gender, age, blood biochemical indexes, liver stiffness, hemodynamic indexes of portal vein system, portal vein diameter （DPV）, portal vein mean blood flow velocity （VPV）, splenic vein diameter （Dsv）, spleen Mean venous blood flow velocity （Vsv）, portal vein blood flow （Qpv）, splenic vein blood flow （Qsv）, etc. Results The blood biochemical indexes, hemodynamic indexes and liver hardness of the three groups were significantly improved after treatment. After treatment, the recovery of blood biochemical indexes, liver hardness and hemodynamic indexes in group A and B were better than those in group C （P < 0.05）; After treatment, compared with group B, ALT and AST decreased, liver hardness decreased, and some portal hemodynamic indexes （DPV, VPV, qpv） recovered better in group A than in group B. Conclusions Tenofovir disoproxil fumarate combined with Ganshuang granule could better improve the liver function, fibrosis and hemodynamic indexes of portal vein system in hepatitis B cirrhosis. The curative effect is significantly better than that of tenofovir disoproxil fumarate alone or combined with Compound Biejia Ruangan Tablet.
- Tenofovir disproxil fumarate,
- Ganshuang granules,
- Hepatitis B cirrhosis,
- Hemodynamics

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