Fan MA, Xiaoxiao WU, Xilin CHU, Ying ZHANG. Pelvic Floor Tthree-dimensional Ultrasound Evaluating Postpartum Pelvic Floor Dysfunction in Elderly Parturient Women[J]. Journal of Kunming Medical University, 2023, 44(6): 64-69. doi: 10.12259/j.issn.2095-610X.S20230616
Citation: Shan HUANG, Song-qin LV, Hong-fen DUAN, Jin-li SHI, Guang-min LI, Gang HUANG, Jia-neng LI, Xiao-fei LI. Cohort Study on the Influence of Opportunistic Infectious Pathogens on the Distribution of Peripheral Blood T Lymphocyte Subsets in Newly Acquired AIDS Patients During Antiretroviral Therapy[J]. Journal of Kunming Medical University, 2021, 42(11): 159-165. doi: 10.12259/j.issn.2095-610X.S20211128

Cohort Study on the Influence of Opportunistic Infectious Pathogens on the Distribution of Peripheral Blood T Lymphocyte Subsets in Newly Acquired AIDS Patients During Antiretroviral Therapy

doi: 10.12259/j.issn.2095-610X.S20211128
  • Received Date: 2021-10-15
    Available Online: 2021-11-16
  • Publish Date: 2021-11-30
  •   Objective  To investigate the influence of opportunistic infectious pathogens on the distribution of peripheral blood T lymphocyte subsets in newly acquired AIDS patients during efficient antiretroviral therapy.   Methods  A total of 220 AIDS patients who were first diagnosed and not performed with antiviral treatment in Infectious Disease Department I of Kunming Third People's Hospital from January 1, 2019 to June 30, 2020 were collected. According to clinical diagnosis, out of 220 patients, 33 patients had AIDS combined with mycobacterium tuberculosis, 30 patients had AIDS combined with hepatitis C virus, 31 patients had AIDS with Talaromyces marneffei, 45 patients had AIDS combined with 1 pathogens, 30 patients had AIDS with 2 pathogens, and 51 patients had AIDS with 3 or more pathogens. The treatment regimen was Tenofovir disoproxil fumarate tablets + lamivudine + EFV (TDF + 3TC + EFV). Anticoagulant samples were collected before treatment, 3, 6 and 12 months after treatment. The peripheral blood T lymphocyte subsets were detected by flow cytometry. The distribution of peripheral blood T lymphocyte subsets in each group during antiviral treatment was compared and analyzed.   Results  The counts of CD3+, CD8+ and CD4+T lymphocyte in 3 groups of patients including the patients with AIDS combined with mycobacterium tuberculosis (AIDS/TB), the patients with AIDS combined with hepatitis c virus (AIDS/HCV) and the patients with AIDS combined with Talaromyces marneffei (AIDS/TM) were significantly increased after 3 months treatment, and the differences were of statistical significance (P < 0.05). As for AIDS/TM group, the CD4+T lymphocyte count increased significantly after 6 months of treatment; As for the other two groups, there was no obvious change of 3 indexes in the subsequent treatment, and the difference was statistically significant. (P > 0.05). There was no significant difference in the count of CD3+ and CD8 + T lymphocytes in the three groups after 1 year of treatment, and the difference was of no statistical significance (P > 0.05); The CD4 + T lymphocyte count in AIDS/HCV group was higher than that of the other two groups, and the difference was statistically significant (P < 0.05). The CD3+ and CD8+T lymphocyte counts increased significantly after 3 months of antiviral treatment in the group of AIDS with 1 pathogen (AIDS/1), and the difference was statistically significant (P < 0.05). There was no significant change in CD4+T lymphocyte count during the whole treatment period, and the difference was no statistically significant (P > 0.05). The CD8+T lymphocyte counts after treatment for 6 months and the CD3+ lymphocyte counts after treatment for 3 months in the group of AIDS with 2 pathogens increased significantly, and the difference was statistically significant (P < 0.05). The CD3+ and CD8+T lymphocyte counts increased significantly after 6 months of treatment in the group of AIDS with 3 or more pathogens (AIDS/≥3); The CD4+T lymphocyte count of AIDS/2 and AIDS/≥3 groups increased significantly after 3 and 6 months of treatment, and the difference was statistically significant (P < 0.05). After one year of treatment, there was no significant difference in CD3+ and CD8+T lymphocyte counts among the three groups, and the difference was no statistically significant (P > 0.05); The CD4+T lymphocyte count of AIDS/1 group was higher than that of the other two groups, and the difference was statistically significant (P < 0.05). The ratio of CD4+/CD8+ in 6 groups was less than 1.   Conclusions  After the standardized efficient antiretroviral therapy, the counts of CD3+ and CD8+T lymphocytes in the peripheral blood of AIDS patients can be restored to the same level, regardless of the type and quantity of opportunistic pathogens. The distribution level of T lymphocyte subsets in the AIDS patients before and after treatment and the type and quantity of opportunistic pathogens will affect the recovery rate and level of CD4+T lymphocyte count during treatment. Three months before the efficient antiretroviral treatment is the key period to evaluate the therapeutic effect, while CD4/CD8 is not an ideal evaluation index.
  • [1]
    Ghosn J,Taiwo B,Seedat S,et al. HIV[J]. Lancet,2018,392(10148):685-697. doi: 10.1016/S0140-6736(18)31311-4
    [2]
    Lu D Y,Wu H Y,Yarla N S,et al. HAART in HIV/AIDS treatments:Future trends[J]. Infect Disord Drug Targets,2018,18(1):15-22. doi: 10.2174/1871526517666170505122800
    [3]
    Cao W,Hsieh E,Li T. Optimizing treatment for adults with HIV/AIDS in China:Successes over two decades and remaining challenges[J]. Curr HIV/AIDS Rep,2020,17(1):26-34. doi: 10.1007/s11904-019-00478-x
    [4]
    Shmakova A,Germini D,Vassetzky Y. HIV-1,HAART and cancer:A complex relationship[J]. Int J Cancer,2020,146(10):2666-2679. doi: 10.1002/ijc.32730
    [5]
    郑艳,王志勇,陈橙,等. HIV感染者/AIDS患者高效抗逆转录病毒治疗感知效果影响因素分析[J]. 重庆医科大学学报,2021,46(4):493-498.
    [6]
    WS293-2019, 艾滋病和艾滋病病毒感染诊断[S]. 北京: 中国标准出版社, 2019.
    [7]
    中华医学会感染病学分会艾滋病丙型肝炎学组,中国疾病预防与控制中心. 中国艾滋病诊疗指南(2018版)[J]. 中华传染病杂志,2018,36(12):705-724. doi: 10.3760/cma.j.issn.1000-6680.2018.12.001
    [8]
    Yang H Y,Beymer M R,Suen S C. Chronic disease onset among people living with HIV and AIDS in a large private insurance claims dataset[J]. Sci Rep,2019,9(1):18514. doi: 10.1038/s41598-019-54969-3
    [9]
    中华人民共和国国家统计局. 中国统计年鉴[M]. 北京: 中国统计出版社, 2019: 23-24.
    [10]
    杜波,马玉霞,田晓东,等. 阜新市高效抗反转录病毒治疗的HIV/AIDS病人基因型耐药情况及影响因素[J]. 中国艾滋病性病,2020,26(8):814-818.
    [11]
    周超,陈宗良,张维,等. 重庆市艾滋病抗病毒治疗新入组病人治疗效果及其影响因素分析[J]. 现代预防医学,2019,46(17):3091-3095.
    [12]
    Jia X C,Xia Z H,Shi N,et al. The factors associated with natural disease progression from HIV to AIDS in the absence of ART,a propensity score matching analysis[J]. Epidemiol Infect,2020,24(5):148-157.
    [13]
    Li Y Y,Yang S H,Wang R R,et al. Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan,China[J]. Int J Dermatol,2020,59(3):308-313. doi: 10.1111/ijd.14725
    [14]
    Yang X,Su B,Zhang X,et al. Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy:Challenges of immunological non-responders[J]. J Leukoc Biol,2020,107(4):597-612. doi: 10.1002/JLB.4MR1019-189R
    [15]
    黄山,吕松琴,徐丽萍,等. 2015-2019年云南地区HIV感染者/AIDS患者合并感染病原微生物特征分析[J]. 临床检验杂志,2021,39(2):151-153.
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