Effects of Probiotics Enteral Nutrition on Ventilator Associated Pneumonia in Patients with Severe Brain Injury

Ze-xi LIN; Li-qing LIN; Jian-ren WANG; Tao XIE; Xi-an FU; Jun PU

doi:10.12259/j.issn.2095-610X.S20211213

Volume 42 Issue 12

Dec. 2021

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Ze-xi LIN, Li-qing LIN, Jian-ren WANG, Tao XIE, Xi-an FU, Jun PU. Effects of Probiotics Enteral Nutrition on Ventilator Associated Pneumonia in Patients with Severe Brain Injury[J]. Journal of Kunming Medical University, 2021, 42(12): 17-22. doi: 10.12259/j.issn.2095-610X.S20211213

Citation:

Ze-xi LIN, Li-qing LIN, Jian-ren WANG, Tao XIE, Xi-an FU, Jun PU. Effects of Probiotics Enteral Nutrition on Ventilator Associated Pneumonia in Patients with Severe Brain Injury[J]. Journal of Kunming Medical University, 2021, 42(12): 17-22. doi: 10.12259/j.issn.2095-610X.S20211213

Citation:

Ze-xi LIN, Li-qing LIN, Jian-ren WANG, Tao XIE, Xi-an FU, Jun PU. Effects of Probiotics Enteral Nutrition on Ventilator Associated Pneumonia in Patients with Severe Brain Injury[J]. Journal of Kunming Medical University, 2021, 42(12): 17-22. doi: 10.12259/j.issn.2095-610X.S20211213

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Effects of Probiotics Enteral Nutrition on Ventilator Associated Pneumonia in Patients with Severe Brain Injury

doi: 10.12259/j.issn.2095-610X.S20211213

Ze-xi LIN¹,
Li-qing LIN¹,
Jian-ren WANG¹,
Tao XIE¹,
Xi-an FU^{1
,
,},
Jun PU^{2
,
,}

1.
Dept. of Neurosurgery，Affiliated Suzhou Hospital of Nanjing Medical University，Suzhou Jiangsu 215008
2.
Dept .of Neurosurgery，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2021-10-15
Available Online: 2021-12-15
Publish Date: 2021-12-15

Abstract

Abstract

Objective To investigate the effect of probiotics combined with early enteral nutrition in the treatment of severe brain injury patients with VAP and the effect of intestinal mucosal barrier function. Methods A total of 84 patients with severe brain injury admitted to the Neurosurgery Department of Suzhou Hospital affiliated to Nanjing Medical University from September 2016 to November 2020 were randomly divided into observation group and control group. Both groups received early enteral nutrition with nasal feeding, and the observation group received additional probiotics on this basis. The incidence of ventilator-associated pneumonia, intestinal mucosal barrier function and gastrointestinal complications were compared between the two groups before and after treatment. Results Compared with the control group, the incidence of VAP in the observation group is lower, the levels of hypersensitive C-reactive protein and procalcitonin were significantly lower at 7th and 21st days after enteral nutrition, plasma D-lactic acid and diamine oxidase concentrations were significantly lower at 7th day after enteral nutrition. Gastrointestinal complications during treatment were significantly lower than those in the control group. And the differences were statistically significant （P < 0.05）. Conclusion Probiotics combined with early enteral nutrition can reduce the incidence of VAP, reduce the release of inflammatory factors, protect the intestinal mucosal barrier function, and reduce gastrointestinal complications.
- Probiotics,
- Severe traumatic brain injury,
- Ventilator-associated pneumonia,
- Intestinal mucosal barrier,
- Enteral nutrition

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References(27)

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