Rectal Cancer Preoperative Clinical Staging and Postoperative Recurrence and Metastasis Prediction by Carcinoembryonic Antigen

An-hui TAN; Teng-fei KE

doi:10.12259/j.issn.2095-610X.S20211217

Volume 42 Issue 12

Dec. 2021

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Discussion on 99mTc-MDP Bone Scan Review Time for Patients with Lung Cancer[J]. Journal of Kunming Medical University, 2011, 32(03).

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An-hui TAN, Teng-fei KE. Rectal Cancer Preoperative Clinical Staging and Postoperative Recurrence and Metastasis Prediction by Carcinoembryonic Antigen[J]. Journal of Kunming Medical University, 2021, 42(12): 36-40. doi: 10.12259/j.issn.2095-610X.S20211217

Discussion on 99mTc-MDP Bone Scan Review Time for Patients with Lung Cancer[J]. Journal of Kunming Medical University, 2011, 32(03).

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Rectal Cancer Preoperative Clinical Staging and Postoperative Recurrence and Metastasis Prediction by Carcinoembryonic Antigen

doi: 10.12259/j.issn.2095-610X.S20211217

An-hui TAN¹,
Teng-fei KE^{2
,
,}

1.
Dept. of Anorectal Medicine，The Traditional Chinese Medicine，Enshi Central Hospital，Enshi Hubei，445000
2.
Dept. of Radiology，Yunnan Cancer Hospital， Kunming Yunnan 650018，China

Received Date: 2021-09-13
Available Online: 2021-11-17
Publish Date: 2021-12-15

Abstract

Abstract

Objective To explore the correlation between preoperative clinical stage, carcinoembryonic antigen and postoperative prognosis in patients with rectal cancer. Methods 200 patients with rectal cancer from October 2013 to October 2015 were collected from The Central Hospital of Enshi Prefecture. Pathological T, N, AND M staging, preoperative CEA value, lesion location, length of involved bowel （measured by CT image）, proportion of involved bowel, positive periintestinal lymph nodes, positive circumferential resection margin, distance from anus, and infiltration of extraneous vessels were collected retrospectively. The patients were followed up to observe whether the patients had recurrence, metastasis and death after surgery, and the time of recurrence, metastasis and death was recorded. Cox multivariate correlation analysis was used to analyze the correlation between the above indicators and postoperative recurrence and metastasis, and to find the factors that predicted postoperative recurrence and metastasis. Recurrence and metastasis were described by Kaplan-Meier curve and their differences were tested by Log-Rank. Results The factors related to postoperative metastasis were N stage, P = 0.001; HR = 11.22; 95%CI （2.55, 49.25）, preoperative CEA value P < 0.001, HR = 1.00; 95%CI （1.002, 1.006）; and these two factors were associated with distant metastasis after surgery. The factors associated with local recurrence were T stage （P = 0.036）; HR = 1.726; 95%CI （1.03, 2.87）, preoperative CEA value P = 0.034; HR = 1.00; 95%CI （0.99, 1.005）. Conclusion T staging was significantly associated with postoperative local recurrence, and N staging was associated with postoperative distant metastasis. Preoperative T staging can predict postoperative local recurrence of rectal cancer. Preoperative N staging and CEA can predict postoperative distant metastasis of rectal cancer.
- Rectal cancer,
- Cox multivariate risk regression,
- Recurrence and metastasis,
- Carcinoembryonic antigen

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[1]	Wasmuth H H,Faerden A E,Myklebust T Å,et al. Transanal total mesorectal excision for rectal cancer has been suspended in Norway[J]. Br J Surg,2020,107(1):121-130.
[2]	Akce M,El-Rayes B F. Nonsurgical management of rectal cancer[J]. Oncol Pract,2019,15(3):123-131. doi: 10.1200/JOP.18.00769
[3]	Van Gijn W,Marijnen C A,Nagtegaal I D,et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer:12-year follow-up of the multicentre,randomised controlled TME trial[J]. Lancet Oncol,2011,12(6):575-582. doi: 10.1016/S1470-2045(11)70097-3
[4]	Fernandez L M,São Julião G P,Figueiredo N L,et al. Conditional recurrence-free survival of clinical complete responders managed by watch and wait after neoadjuvant chemoradiotherapy for rectal cancer in the International Watch & Wait Database:A retrospective,international,multicentre registry study[J]. Lancet Oncol,2021,22(1):43-50. doi: 10.1016/S1470-2045(20)30557-X
[5]	Alonso S,Pascual M,Salvans S,et al. Postoperative intra-abdominal infection and colorectal cancer recurrence:A prospective matched cohort study of inflammatory and angiogenic responses as mechanisms involved in this association[J]. Eur Surg Oncol,2015,41(2):208-214. doi: 10.1016/j.ejso.2014.10.052
[6]	Van Oostendorp S E,Belgers H J E,Hol J C,et al. The learning curve of transanal total mesorectal excision for rectal cancer is associated with local recurrence:Results from a multicentre external audit[J]. Colorectal Dis,2021,23(8):2020-2029. doi: 10.1111/codi.15722
[7]	刘启志, 郝立强, 楼征, 等结直肠癌术后早期和晚期复发转移与临床病理特征的关系[J]. 中华普通外科杂志, 2019, 34（8）: 675-678.
[8]	Lacy A M,Nogueira S T,Lacy F. Comment on:Norwegian moratorium on transanal total mesorectal excision[J]. British Journal Surgery,2019,106(13):1855-1855.
[9]	蒲竞,陈晓红,王慧春,等. 血清CEA、CA19-9及PET-CT SUV值对结直肠癌患者术后复发/转移的诊断价值[J]. 中国肛肠病杂志,2019,39(8):1-4. doi: 10.3969/j.issn.1000-1174.2019.08.001
[10]	Achilli P,Radtke TS,Lovely J K,et al. Preoperative predictive risk to cancer quality in robotic rectal cancer surgery[J]. Eur Surg Onco,2021,47(2):317-322. doi: 10.1016/j.ejso.2020.08.019
[11]	São Julião G P,Habr-Gama A,Vailati B B,et al. New strategies in rectal Cancer[J]. Surg Clin North Am,2017,97(3):587-604. doi: 10.1016/j.suc.2017.01.008
[12]	Walters S,Benitez Majano S,Muller P,et al. Is England closing theinternational gap in cancer survival?[J]. Br Cancer,2015,113(5):848-860. doi: 10.1038/bjc.2015.265
[13]	Benitez Majano S,Di Girolamo C,Rachet B,et al. Surgical treatment andsurvival from colorectal cancer in Denmark,England,Norway,and Sweden:A population-based study[J]. Lancet Onco ,2019,20(1):74-87. doi: 10.1016/S1470-2045(18)30646-6

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