Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis

Jin-rong YANG; Kun WU; Bo NIE; Zhen-xin HE; Yu-yu YANG; Jie SUN; Yun ZENG

doi:10.12259/j.issn.2095-610X.S20211220

Volume 42 Issue 12

Dec. 2021

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Jin-rong YANG, Kun WU, Bo NIE, Zhen-xin HE, Yu-yu YANG, Jie SUN, Yun ZENG. Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis[J]. Journal of Kunming Medical University, 2021, 42(12): 51-58. doi: 10.12259/j.issn.2095-610X.S20211220

Citation:

Jin-rong YANG, Kun WU, Bo NIE, Zhen-xin HE, Yu-yu YANG, Jie SUN, Yun ZENG. Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis[J]. Journal of Kunming Medical University, 2021, 42(12): 51-58. doi: 10.12259/j.issn.2095-610X.S20211220

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Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis

doi: 10.12259/j.issn.2095-610X.S20211220

1.
Dept. of Hematology，The 1st Affiliated Hospital of Kunming Medical University，Yunnan Institute of Hematology，Kunming Yunnan 650032
2.
Clinical Laboratory，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032， China

Received Date: 2021-10-16
Available Online: 2021-11-17
Publish Date: 2021-12-15

Abstract

Abstract

Objective To analyze the clinical features of adult hemophagocytic syndrome （HPS） and the correlation between the levels of various cytokines and prognosis. Methods The data of 19 adult patients with hemophagocytic syndrome were collected, and the clinical features and laboratory tests were analyzed. The blood samples were collected for 12 cytokine levels detection, and the correlation between the levels and prognosis was analyzed. Results The levels of cytokines IL-1β, IL-2, IL-4, IL-8, IL-10, IL-6, IFN-γand TNF-α in HPS patients were higher than those in non-HPS non-infected patients （P < 0.05）. The levels of IL-4, IL-5, IL-10, IFN-γ and TNF-α in HPS patients were higher than those in non-HPS patients （P < 0.05）, the ROC curve of IL-10, IFN-γ and TNF-α showed that the AUC of IL-10, IFN-γ and TNF-α was between 0.7 and 0.9, indicating accuracy in the diagnosis of HPS. Fib was significantly lower than that in the survival group （P < 0.05）, while there were no significant differences in age, sex, clinical features （fever, liver, spleen, lymphadenopathy） and laboratory tests （ALT, AST, TBIL, ALB, Fer, TG, ACN, HGB, PLT） between the HPS death group and the survival group （P > 0.05）, and the levels of IL-1β, IL-8 and TNF-α in HPS death group were significantly higher than those in survival group （P < 0.05）. Conclusion HPS may present increased levels of various cytokines, among which IL-10, IFN-γ and TNF-α may be significant for the diagnosis of HPS. The significant decrease of Fib and the significant increase of IL-1β, IL-8 and TNF-α may indicate a poor prognosis.
- Hemophagocytic syndrome,
- Clinical features,
- Cytokines

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References(18)

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