Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis

Jin-rong YANG; Kun WU; Bo NIE; Zhen-xin HE; Yu-yu YANG; Jie SUN; Yun ZENG

doi:10.12259/j.issn.2095-610X.S20211220

Volume 42 Issue 12

Dec. 2021

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2021 > 42(12): 51-58

Jin-rong YANG, Kun WU, Bo NIE, Zhen-xin HE, Yu-yu YANG, Jie SUN, Yun ZENG. Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis[J]. Journal of Kunming Medical University, 2021, 42(12): 51-58. doi: 10.12259/j.issn.2095-610X.S20211220

Citation:

Jin-rong YANG, Kun WU, Bo NIE, Zhen-xin HE, Yu-yu YANG, Jie SUN, Yun ZENG. Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis[J]. Journal of Kunming Medical University, 2021, 42(12): 51-58. doi: 10.12259/j.issn.2095-610X.S20211220

Citation:

PDF( 712 KB)

Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis

doi: 10.12259/j.issn.2095-610X.S20211220

1.
Dept. of Hematology，The 1st Affiliated Hospital of Kunming Medical University，Yunnan Institute of Hematology，Kunming Yunnan 650032
2.
Clinical Laboratory，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032， China

Received Date: 2021-10-16
Available Online: 2021-11-17
Publish Date: 2021-12-15

Abstract

Abstract

Objective To analyze the clinical features of adult hemophagocytic syndrome （HPS） and the correlation between the levels of various cytokines and prognosis. Methods The data of 19 adult patients with hemophagocytic syndrome were collected, and the clinical features and laboratory tests were analyzed. The blood samples were collected for 12 cytokine levels detection, and the correlation between the levels and prognosis was analyzed. Results The levels of cytokines IL-1β, IL-2, IL-4, IL-8, IL-10, IL-6, IFN-γand TNF-α in HPS patients were higher than those in non-HPS non-infected patients （P < 0.05）. The levels of IL-4, IL-5, IL-10, IFN-γ and TNF-α in HPS patients were higher than those in non-HPS patients （P < 0.05）, the ROC curve of IL-10, IFN-γ and TNF-α showed that the AUC of IL-10, IFN-γ and TNF-α was between 0.7 and 0.9, indicating accuracy in the diagnosis of HPS. Fib was significantly lower than that in the survival group （P < 0.05）, while there were no significant differences in age, sex, clinical features （fever, liver, spleen, lymphadenopathy） and laboratory tests （ALT, AST, TBIL, ALB, Fer, TG, ACN, HGB, PLT） between the HPS death group and the survival group （P > 0.05）, and the levels of IL-1β, IL-8 and TNF-α in HPS death group were significantly higher than those in survival group （P < 0.05）. Conclusion HPS may present increased levels of various cytokines, among which IL-10, IFN-γ and TNF-α may be significant for the diagnosis of HPS. The significant decrease of Fib and the significant increase of IL-1β, IL-8 and TNF-α may indicate a poor prognosis.
- Hemophagocytic syndrome,
- Clinical features,
- Cytokines

FullText(HTML)

References(18)

References

[1]	Risdall R J,McKenna R W,Nesbit M E,et al. Virus-associated hemophagocytic syndrome:A benign histiocytic proliferation distinct from malignant histiocytosis[J]. Cancer,1979,44(3):993-1002. doi: 10.1002/1097-0142(197909)44:3<993::AID-CNCR2820440329>3.0.CO;2-5
[2]	张之南, 沈悌. 血液病诊断及疗效标准[M]. 第3版. 北京: 科学出版社, 2007: 254-256.
[3]	Ramos Casals M,Brito Zerón P,López Guillermo A,et al. Adult haemophagocytic syndrome[J]. Lancet,2014,383(9927):1503-1516. doi: 10.1016/S0140-6736(13)61048-X
[4]	KumaKura S,Yamaguchi Y,Murakawa Y,et al. Effect of cytokines and hyperthermia on phagocytosis and phosphatidyiserine externliza- tion:Implication for the pathophysiology of hemophagocytic syndrome[J]. Ann Clin Lab Sci,2018,48(3):314-322.
[5]	Grom A A. Natural killer cell dysfunction: A common pathway in Systemiconset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis[J] Arthritis & Rheumatism, 2004, 50（3）: 689-698.
[6]	Wang,Xueqin,Pan,et al. Conditional distance correlation[J]. J Am Stat Assoc,2015,110(512):1726-1734. doi: 10.1080/01621459.2014.993081
[7]	Yoon J H,Park S S,Jeon Y W,et al. Treament outcomes and prognostic factors in adult patients with secondary hemophagocytic lympho- histiocytosis not associated with malignancy[J]. Haematologica,2019,104(2):269-276. doi: 10.3324/haematol.2018.198655
[8]	Zhao Y,Lu D,Ma S,et al. Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis:A single-in- stitution study of 171 Chinese patients[J]. Hematology,2019,24(1):606-612. doi: 10.1080/16078454.2019.1660458
[9]	闫丽娟,王昭. 噬血细胞综合征继发性凝血功能障碍的认识与研究[J]. 临床和实验医学杂志,2012,11(2):142-143. doi: 10.3969/j.issn.1671-4695.2012.02.034
[10]	Chen L,Weng H,Li H,et al. Potential killer in the ICU-severe tuberculosis combined with hemophagocytic syndrome:A case series and literature review[J]. Medicine,2017,96(49):1-5.
[11]	Mqller H J. Soluble CD163[J]. Scand J Clin Lab In-vest,2012,72(1):1-13. doi: 10.3109/00365513.2011.626868
[12]	Sieni E,Cetica V,Mastrodicasa E,et al. Familial hemophagocytic lymphohis- tiocytosis:A model for understanding the human machinery of cellular cytotoxicity[J]. Cell Mol Life Sci,2012,69(1):29-40. doi: 10.1007/s00018-011-0835-y
[13]	Gayden T,Sepulveda F E,Khuong-Quang D A,et al. Author correction:germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome[J]. Nat Genet,2019,51(1):196.
[14]	Hiroi M,Sakaeda Y,Yamaguchi H,et al. Anti-inflammatory cytokine interleukin-4 inhibits inducible nitric oxide synthase gene expression in the mouse macrophage cell line RAW264.7 through the repression of octamer dependent transcription[J]. Mediators of Inflammation,2013,2013(1):1-15.
[15]	Klementiev B,Enevoldsen M N,Li S,et al. Anti - inflammatory properties of a peptide derived from interleukin-4[J]. Cytokine,2013,64(1):112-121. doi: 10.1016/j.cyto.2013.07.016
[16]	Akdis M,Aab A,Altunbulakli C,et al. Interleukins( from IL-1 to IL-38),interferons,transforming growth factor beta,and TNF-alpha:Receptors,functions,and roles in diseases[J]. J Allergy Clin Immunol,2016,138(4):984-1010. doi: 10.1016/j.jaci.2016.06.033
[17]	Yoshimura T,Matsushima K,Oppenheim J,et al. Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimula ted human blood mononuclear leukocytes:Partial characterization and separation from interleukin 1 ( IL-1)[J]. J Immunol,1987,139(3):788-793.
[18]	Peiro T,Patel D F,Akthar S,et al. Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection[J]. Thorax,2018,73(6):546-556. doi: 10.1136/thoraxjnl-2017-210010

Relative Articles(20)

Relative Articles

[1]	Minhui ZHANG, Weidan YIN, Zhulin HU, Hua LI, Liwei ZHANG, Yuling REN. Clinical Features and Prognosis of Acute Macular Neuroretinopathy Associated with Novel Coronavirus Infection. Journal of Kunming Medical University, 2025, 46(4): 1-9.
[2]	Jianfang MA, Xiaoling HUANG, Yanhua LI, Di MA, Kaifen YUAN. Analysis of Clinical Characteristics and Death Risk Factors in Patients with Community-acquired Pneumonia Complicated with Diabetes. Journal of Kunming Medical University, 2024, 45(2): 123-130. doi: 10.12259/j.issn.2095-610X.S20240217
[3]	Xinye YANG, Nian ZHANG, Sha MA, Linpei HUANG, Xueyi LI, Xiaoping HUANG, Mi ZHANG, Cuixian YANG, Xicheng WANG. Analysis of Laboratory Index Characteristics in Newly Treated Smear-Negative Pulmonary Tuberculosis Patients. Journal of Kunming Medical University, 2024, 45(9): 56-61. doi: 10.12259/j.issn.2095-610X.S20240909
[4]	Shibing QIAN, Huiping SHI, Yanqiu LI, Rongyu YANG, Kaiwen DUAN. Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells. Journal of Kunming Medical University, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926
[5]	Fen LI, Jie ZHAO, Haixi ZHANG, Lin ZHANG, Xuezhong GU. The Correlation of Iron Metabolism Indexes，Cytokines，and Liver Function in Patients with Hemophagocytic Syndrome. Journal of Kunming Medical University, 2024, 45(11): 110-116. doi: 10.12259/j.issn.2095-610X.S20241115
[6]	Weijie LI, Liqin CHEN, Yaling LI, Yonghui HAN, Xiaojuan LI, Fendong YAN. Epidemiology, Clinical Characteristics and Risk Factors of 148 Severe Pertussis Cases in Yunnan. Journal of Kunming Medical University, 2022, 43(8): 145-149. doi: 10.12259/j.issn.2095-610X.S20220824
[7]	Weimin LU, Xiaotao YANG, Ying ZHU, Yi HUANG, Houyu CHEN, Haifeng JIN, Yanchun WANG. Clinical Features and Risk Factors for Critical Cases of Scrub Typhus in 175 Children. Journal of Kunming Medical University, 2022, 43(8): 72-80. doi: 10.12259/j.issn.2095-610X.S20220814
[8]	Zhiying LU, Meifen WANG, Junchao PENG, Zengqing DU, Yunjiao LUO, Wei MA. Comparison of Serum PCT, IL-6, SAA Levels and Clinical Characteristics between Rotavirus and Norovirus Enteritis in Children. Journal of Kunming Medical University, 2022, 43(8): 138-144. doi: 10.12259/j.issn.2095-610X.S20220823
[9]	Kun ZHAO, Yun XIAO, Chun YANG, Zhiling YAN, Minna DONG, Bingquan XIANG, Mingyao XIAO. Protective Effect of Interleukin-4 in Lipopolysaccharide-induced Acute Lung Injury Models. Journal of Kunming Medical University, 2022, 43(8): 41-46. doi: 10.12259/j.issn.2095-610X.S20220805
[10]	Yong-ji FU, Fei PENG, Mei GUO, Hua YAN, Qing-cheng SHEN, Jin-xi BAI, Liu YANG. Clinical Characteristics of Gastric Cancer in Young Patients: A Retrospective Cohort Study. Journal of Kunming Medical University, 2021, 42(5): 81-86. doi: 10.12259/j.issn.2095-610X.S20210515
[11]	Wei-sha ZHOU, Le ZHANG, Jing PENG, Shou-kun CHEN, Meng-jun LIU, Xiao FU, Zhi-fei TANG, Yun-xuan YUE. Effect of Plasma Exchange with Double Plasma Molecular Adsorption on Cytokines in Autoimmune Hepatitis with Liver Failure. Journal of Kunming Medical University, 2021, 42(4): 73-77. doi: 10.12259/j.issn.2095-610X.S20210414
[12]	Hui-bo YANG, Qin MIAO, De-liang LIU, Si-si LI. Clinical Study on Characteristics of Kawasaki Disease in Yunnan Province. Journal of Kunming Medical University, 2020, 41(11): 103-108. doi: 10.12259/j.issn.2095-610X.S20201121
[13]	Wei-jia ZHAO, Hong-bin LI, Zong-han CHEN. Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol. Journal of Kunming Medical University, 2020, 41(12): 99-103. doi: 10.12259/j.issn.2095-610X.S20201227
[14]	Wang Yan Chun , Du Zeng Qing , Liu Mei , Wang Mei Fen , Huang Yong Kun . . Journal of Kunming Medical University, 2018, 39(10): 97-100.
[15]	Ji Xiao Fei , Zhang Ting Ting , Zhao Bo , Liu Mei , Xiong Jing Jing , Liao Ya Bin , Zhao Ya Ling , Ding Zhen Bo , Huang Yong Kun . Change and Significance of Cytokine Levels in Children with Different Types of Henoch-Schonlein Purpura. Journal of Kunming Medical University, 2016, 37(11): 46-50.
[16]	Li Yan Ping . The Clinical Characteristics of Patients with Chronic Heart Failure with Preserved Ejection Fraction. Journal of Kunming Medical University,
[17]	Yang Jing . . Journal of Kunming Medical University,
[18]	Yang De Xing . . Journal of Kunming Medical University,
[19]	Li Xian Li . . Journal of Kunming Medical University,
[20]	Zhou Hong . . Journal of Kunming Medical University,