Application of Myocardial Ischemia Preconditioning in Paclitaxel-Eluting Coronary Balloon Dilatation Coronary Angioplasty Catheterization

Shuo WANG; Ai SUN; Hui-jie ZHANG; Yang YOU; Li-ye WEI; Liu LI

doi:10.12259/j.issn.2095-610X.S20211225

Volume 42 Issue 12

Dec. 2021

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Shuo WANG, Ai SUN, Hui-jie ZHANG, Yang YOU, Li-ye WEI, Liu LI. Application of Myocardial Ischemia Preconditioning in Paclitaxel-Eluting Coronary Balloon Dilatation Coronary Angioplasty Catheterization[J]. Journal of Kunming Medical University, 2021, 42(12): 89-94. doi: 10.12259/j.issn.2095-610X.S20211225

Citation:

Shuo WANG, Ai SUN, Hui-jie ZHANG, Yang YOU, Li-ye WEI, Liu LI. Application of Myocardial Ischemia Preconditioning in Paclitaxel-Eluting Coronary Balloon Dilatation Coronary Angioplasty Catheterization[J]. Journal of Kunming Medical University, 2021, 42(12): 89-94. doi: 10.12259/j.issn.2095-610X.S20211225

Citation:

Shuo WANG, Ai SUN, Hui-jie ZHANG, Yang YOU, Li-ye WEI, Liu LI. Application of Myocardial Ischemia Preconditioning in Paclitaxel-Eluting Coronary Balloon Dilatation Coronary Angioplasty Catheterization[J]. Journal of Kunming Medical University, 2021, 42(12): 89-94. doi: 10.12259/j.issn.2095-610X.S20211225

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Application of Myocardial Ischemia Preconditioning in Paclitaxel-Eluting Coronary Balloon Dilatation Coronary Angioplasty Catheterization

doi: 10.12259/j.issn.2095-610X.S20211225

1.
Dept. of Cardiology，Shijiazhuang People’s Hospital，Shijiazhuang Hebei 050011
2.
Dept. of Cardiology，Hebei Medical University First Hospital，Shijiazhuang Hebei 050011，China

Received Date: 2021-10-17
Available Online: 2021-11-24
Publish Date: 2021-12-15

Abstract

Abstract

Objective To evaluate the efficacy of myocardial ischemic preconditioning in paclitaxel eluting PTCA balloon catheter. Methods A total of 210 patients who underwent paclitaxel eluting PTCA balloon catheter were randomly divided into 3 groups. The control group received percutaneous paclitaxel eluting coronary balloon dilatation coronary angioplasty was performed according to the routine operation; The second group, half minute ischemic preconditioning group, received non compliant balloon dilation twice for 30 seconds interval 3 minutes. The third group, minute ischemic preconditioning group, received non compliant balloon dilation was applied twice for 60 seconds interval 3 minutes. Coronary SYNTAX II scores were recorded for all patients, percutaneous transluminal coronary angioplasty （PTCA）, the values of creatine kinase （CK）, creatine kinase isoenzyme （CK-MB） and cardiac troponin I （cTnI） were recorded before and 24 hours after operation. All patients were followed up for MACE events （including cardiac death, myocardial infarction, heart failure, cardiac readmission, target vessel re-vascularization） and improvement of clinical symptoms within 180 days after surgery. Results （1） There was no significant difference in myocardial injury markers before PTCA, occurrence of angina pectoris, tachyarrhythmia and bradyarrhythmia during PTCA among the three groups （P＞0.05）, but the myocardial injury markers 24 hours after PTCA in 1 minute ischemic preconditioning group was significantly lower than that in the control group and half minute preconditioning group （P < 0.05）; （2） The incidence of MACE events and the improvement of clinical symptoms within 180 days after PTCA in 1 minute ischemic preconditioning group were significantly better than those in the control group and half minute preconditioning group （P < 0.05）. Conclusion （1） Myocardial ischemic preconditioning in paclitaxel eluting coronary balloon catheter can reduce myocardial injury; （2） Myocardial ischemic preconditioning in paclitaxel eluting coronary balloon catheter can improve the prognosis and clinical symptoms of PTCA.

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References(25)

References

[1]	卢长林,郭炜华,杨跃进,等. 冠状动脉支架内再狭窄的现状与展望[J]. 中国心血管杂志,2012,17(6):409-412. doi: 10.3969/j.issn.1007-5410.2012.06.003
[2]	Scheller B,Speck U,Abramjuk C,et al. Paclitaxel balloon coating,a novel method for prevention and therapy of restenosis[J]. Circulation,2004,110(7):810-814. doi: 10.1161/01.CIR.0000138929.71660.E0
[3]	付强,苗志林,李占全. 药物洗脱球囊的研究进展[J]. 中国介入心脏病学杂志,2011,19(2):111-113. doi: 10.3969/j.issn.1004-8812.2011.02.015
[4]	Murry C E,Jennings R B,Reimer K A. Preconditioning with ischemia:A delay of lethal cell injury in ischemic myocardium[J]. Circulation,1986,74(12):1124-1136.
[5]	Laskey W K. Beneficial impact of preconditioning during PTCA on creatine kinase release[J]. Circulation,1999,99(16):2085-2089. doi: 10.1161/01.CIR.99.16.2085
[6]	周忠江, 侯玉清. 药物涂层球囊在冠状动脉介入治疗中的应用进展[J]. 中国介入心脏病学杂志, 2014, 22（ 3） : 191-194.
[7]	《药物涂层球囊临床应用中国专家共识》专家组. 药物涂层球囊临床应用中国专家共识[J]. 中国介入心脏病学杂志,2016,24(2):61-67.
[8]	Kloner R A,Rezkalla S H. Cardiac protection during acute myocardial in- farction:Where do we stand in 2004[J]. Am Coll Cardiol,2004,44(2):276-286.
[9]	Rezkalla S H,Kloner R A. Ischemic preconditioning and preinfarction angina in the clinical arena[J]. Nat Clin Pract Cardiovasc Med,2004,1(2):96-102.
[10]	Neumann F J,Sousa Uva M,Ahlsson A,et al. 2018 ESC/EACTSGuidelines on myocardial revascularization[J]. Euro Intervention,2019,14(14):1435-1534.
[11]	Jeger R V,Eccleshall S,WAan Ahmao. W A,et al. Drug coated balloons for coronary artery disease:Third report of the International DCB consensus Group[J]. JACC Cardiovasc Interv,2020,13(12):1391-1402. doi: 10.1016/j.jcin.2020.02.043
[12]	方忠林,谢志泉. 心肌缺血预适应的心脏保护机制研究进展[J]. 心血管病学进展,2006,27(3):342-346.
[13]	Kuzume K,Wolff R A,Amakawa K,et al. Sustained exogenous administration of Met5-enkephalin protects against infarction in vivo[J]. American Journal of Physiology Heart & Circulatory Physiology,2003,285(6):2463.
[14]	H Thomas L,Emala C W. Preconditioning and adenosine protect human proximal tubule cells in an in vitro model of ischemic injury[J]. Journal of the American Society of Nephrology Jasn,2002,13(11):2753-2761. doi: 10.1097/01.ASN.0000032421.79225.6E
[15]	Lochner A,Marais E,Du T E,et al. Nitric oxide triggers classic ischemic preconditioning[J]. Ann N Y Acad Sci,2010,962(1):402-414.
[16]	Verma A,Hirsch D J,Glatt C E,et al. Carbon monoxide:A putative neural messenger[J]. Science,1993,259(5093):381-384. doi: 10.1126/science.7678352
[17]	QJ S,YJ L,HW D. Early and delayed cardioprotection by heat stress is mediated by calcitonin gene-related peptide[J]. Naunyn-Schmiedeberg’Sarchives of Pharmacology,1999,89(2):168-173.
[18]	查道刚,冯力,刘伊丽. 经静脉心肌声学造影技术评价 ATP 敏感钾通道的开放对心肌缺血的保护作用[J]. 中国超声医学杂志,2001,17(2):81-84. doi: 10.3969/j.issn.1002-0101.2001.02.001
[19]	任静娟, 郭平. 阿托品联合缺血预适应对急性心肌梗死患者再灌注心律失常的影响[ J]. 血栓与止血学, 2019, 23（5）: 511-513.
[20]	黄晓飞, 马驰千, 康小涛, 等. 梗死前心绞痛产生的缺血预适应对急诊经皮冠状动脉介入治疗患者的心肌保护作用[ J]. 岭南心血管病杂志, 2020, 23（4）: 201-272.
[21]	Yu X,J I F,X U F,et al. Treatment of large denovo coronary lesions with paclitaxel-coatedballoon only:Results from a Chinese institute[J]. Clin Res Cardiol,2019,32(108):234-243.
[22]	Scheller B,Ohlow M A,Ewen,et al. Randomizedcomparison of bare metal or drug-elutingstent versus drug coated balloon in non-STelevationmyocardial infarction—PEPCAD NSTEMI[J]. Euro Intervention,2020,31(85):267-275.
[23]	Sinha M K,Vazquez J M,Calvino R,et al. Effects of balloon occlusion during percutaneous coronary intervention on circulating ischemia modified albumin and transmyocardial lactate extraction[J]. Heart,2006,92(12):1852-1853. doi: 10.1136/hrt.2005.078089
[24]	Vos N S,Fagel N D,Amoroso G,et al. Paclitaxel-coated balloon angioplasty versus drugelutingstent in acute myocardial infarction:The REVELATION randomized trial[J]. J Am Coll CardiolIntv,2019,25(12):1691-1699.
[25]	王丽娜. 整体护理对急性心肌梗死介入治疗中心律失常患者的影响114例分析[J]. 中国医药指南,2019,17(6):246.

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