Advances on FBP1’<b><bold/></b>s Role in Malignant Tumors

Xiao-tao LI; Hai-feng WANG; Jian-song WANG

doi:10.12259/j.issn.2095-610X.S20211237

Volume 42 Issue 12

Dec. 2021

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Xiao-tao LI, Hai-feng WANG, Jian-song WANG. Advances on FBP1’s Role in Malignant Tumors[J]. Journal of Kunming Medical University, 2021, 42(12): 156-160. doi: 10.12259/j.issn.2095-610X.S20211237

Citation:

Xiao-tao LI, Hai-feng WANG, Jian-song WANG. Advances on FBP1’s Role in Malignant Tumors[J]. Journal of Kunming Medical University, 2021, 42(12): 156-160. doi: 10.12259/j.issn.2095-610X.S20211237

Xiao-tao LI, Hai-feng WANG, Jian-song WANG. Advances on FBP1’s Role in Malignant Tumors[J]. Journal of Kunming Medical University, 2021, 42(12): 156-160. doi: 10.12259/j.issn.2095-610X.S20211237

Citation:

Xiao-tao LI, Hai-feng WANG, Jian-song WANG. Advances on FBP1’s Role in Malignant Tumors[J]. Journal of Kunming Medical University, 2021, 42(12): 156-160. doi: 10.12259/j.issn.2095-610X.S20211237

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Advances on FBP1’s Role in Malignant Tumors

doi: 10.12259/j.issn.2095-610X.S20211237

Dept. of Urology，The 2nd Affiliated hospital of Kunming Medical University / Yunnan Urinary System Disease Clinical Medical Center，Kunming Yunnan 650101，China

Received Date: 2021-09-15
Publish Date: 2021-12-25

Abstract

Abstract

As a key enzyme in the process of gluconeogenesis, FBP1 controls the rate of gluconeogenesis and catalyzes the irreversible hydrolysis of fructose 1-6 diphosphate into fructose 6-phosphate and inorganic phosphate, thereby controlling the rate of gluconeogenesis and affecting cellular glycolysis. In recent years, its role in malignant tumors has attracted more and more attention. Studies have found that FBP1 is abnormally expressed in a variety of tumors and is closely related to tumor occurrence and prognosis. These results show a good prospect for tumor molecular markers, targeted drug research, and prognosis-related research.
- FBP1,
- Aerobic glycolysis,
- Warburg effect,
- Cancer

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References(36)

References

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