Advances on FBP1’<b><bold/></b>s Role in Malignant Tumors

Xiao-tao LI; Hai-feng WANG; Jian-song WANG

doi:10.12259/j.issn.2095-610X.S20211237

Volume 42 Issue 12

Dec. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(12): 156-160

Xiao-tao LI, Hai-feng WANG, Jian-song WANG. Advances on FBP1’s Role in Malignant Tumors[J]. Journal of Kunming Medical University, 2021, 42(12): 156-160. doi: 10.12259/j.issn.2095-610X.S20211237

Citation:

Xiao-tao LI, Hai-feng WANG, Jian-song WANG. Advances on FBP1’s Role in Malignant Tumors[J]. Journal of Kunming Medical University, 2021, 42(12): 156-160. doi: 10.12259/j.issn.2095-610X.S20211237

Xiao-tao LI, Hai-feng WANG, Jian-song WANG. Advances on FBP1’s Role in Malignant Tumors[J]. Journal of Kunming Medical University, 2021, 42(12): 156-160. doi: 10.12259/j.issn.2095-610X.S20211237

Citation:

Xiao-tao LI, Hai-feng WANG, Jian-song WANG. Advances on FBP1’s Role in Malignant Tumors[J]. Journal of Kunming Medical University, 2021, 42(12): 156-160. doi: 10.12259/j.issn.2095-610X.S20211237

PDF( 533 KB)

Advances on FBP1’s Role in Malignant Tumors

doi: 10.12259/j.issn.2095-610X.S20211237

Dept. of Urology，The 2nd Affiliated hospital of Kunming Medical University / Yunnan Urinary System Disease Clinical Medical Center，Kunming Yunnan 650101，China

Received Date: 2021-09-15
Publish Date: 2021-12-25

Abstract

Abstract

As a key enzyme in the process of gluconeogenesis, FBP1 controls the rate of gluconeogenesis and catalyzes the irreversible hydrolysis of fructose 1-6 diphosphate into fructose 6-phosphate and inorganic phosphate, thereby controlling the rate of gluconeogenesis and affecting cellular glycolysis. In recent years, its role in malignant tumors has attracted more and more attention. Studies have found that FBP1 is abnormally expressed in a variety of tumors and is closely related to tumor occurrence and prognosis. These results show a good prospect for tumor molecular markers, targeted drug research, and prognosis-related research.
- FBP1,
- Aerobic glycolysis,
- Warburg effect,
- Cancer

FullText(HTML)

References(36)

References

[1]	Wang H,Naghavi M,Allen C,et al. Global,regional,and national life expectancy,all-cause mortality,and cause-specific mortality for 249 causes of death,1980-2015:A systematic analysis for the global burden of disease study 2015[J]. Lancet,2016,388(10053):1459-1544. doi: 10.1016/S0140-6736(16)31012-1
[2]	Sung H,Ferlay J,Siegel R,et al. Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA-A Cancer Journal For Clinicians,2021,70(4):1-41.
[3]	Ke H,Liang J,Zhang Y,et al. Conformational transition of fructose-1,6-bisphosphatase:Structure comparison between the AMP complex (T form) and the fructose 6-phosphate complex (R form)[J]. Biochemistry,1991,30(18):4412-4420. doi: 10.1021/bi00232a007
[4]	Moon S,Kim J,Han J,et al. Novel compound heterozygous mutations in the fructose-1,6-bisphosphatase gene cause hypoglycemia and lactic acidosis[J]. Metablism,2011,60(1):107-113. doi: 10.1016/j.metabol.2009.12.021
[5]	Gonzales P,Pisitkun T,Hoffert J,et al. Large-scale proteomics and phosphoproteomics of urinary exosomes[J]. J Am Soc Nephrol,2009,20(2):363-379. doi: 10.1681/ASN.2008040406
[6]	Consortium T U. UniProt:A worldwide hub of protein knowledge[J]. Nucleic Acids Research,2019,47(1):D506-D515. doi: 10.1093/nar/gky1049
[7]	Yánez A,Nualart F,Droppelmann C,et al. Broad expression of fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase provide evidence for gluconeogenesis in human tissues other than liver and kidney[J]. Journal of Cellular Physiology,2003,197(2):189-197. doi: 10.1002/jcp.10337
[8]	X L,X W,J Z,et al. Warburg effect revisited:An epigenetic link between glycolysis and gastric carcinogenesis[J]. Oncogene,2010,29(3):442-450. doi: 10.1038/onc.2009.332
[9]	Li J,Wang Y,Li Q G,et al. Downregulation of FBP1 promotes tumor metastasis and indicates poor prognosis in gastric cancer via regulating epithelial-mesenchymal transition[J]. PLoS One,2016,11(12):1-15.
[10]	Yu J,Li J,Chen Y,et al. Snail Enhances glycolysis in the epithelial-mesenchymal transition process by targeting FBP1 in gastric cancer[J]. Cell Physiol Biochem,2017,43(1):31-38. doi: 10.1159/000480314
[11]	Li B,Qiu B,Lee D S,et al. Fructose-1,6-bisphosphatase opposes renal carcinoma progression[J]. Nature,2014,513(7517):251-255. doi: 10.1038/nature13557
[12]	洪正东,朱安义,王艳华,等. FBP1在肾透明细胞癌组织中的表达变化及意义[J]. 重庆医学,2018,47(14):44-47.
[13]	R C, X Z, G H, et al. Fructose 1, 6-bisphosphatase 1 expression reduces ¹⁸F-FDG uptake in clear cell renal cell carcinoma[J]. Contrast Media & Molecular Imaging, 2019, 2019（期?）: 1-6. R C,X Z,G H,et al. Fructose 1,6-bisphosphatase 1 expression reduces ¹⁸F-FDG uptake in clear cell renal cell carcinoma[J]. Contrast Media & Molecular Imaging,2019,2019:1-6.
[14]	Zhu Y,Shi M,Chen H,et al. NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells[J]. Oncotarget,2015,6(25):21443-21451. doi: 10.18632/oncotarget.4167
[15]	Chen L Y,Cheng C S,Qu C,et al. CBX3 promotes proliferation and regulates glycolysis via suppressing FBP1 in pancreatic cancer[J]. Biochem Biophys Res Commun,2018,500(3):691-697. doi: 10.1016/j.bbrc.2018.04.137
[16]	Wang B,Fan P,Zhao J,et al. FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma[J]. J Exp Clin Cancer Res,2018,37(1):224-235. doi: 10.1186/s13046-018-0888-y
[17]	Jin X,Pan Y,Wang L,et al. Fructose-1,6-bisphosphatase inhibits ERK activation and bypasses gemcitabine resistance in pancreatic cancer by blocking IQGAP1-MAPK interaction[J]. Cancer Research,2017,77(16):4328-4341. doi: 10.1158/0008-5472.CAN-16-3143
[18]	C Y,S Z,H Y,et al. USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1[J]. American Journal of Cancer Research,2019,9(8):1722-1733.
[19]	Chen M,Zhang J,Li N,et al. Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer[J]. PLoS One,2011,6(10):1-8.
[20]	J Y,C W,F Z,et al. Loss of FBP1 facilitates aggressive features of hepatocellular carcinoma cells through the Warburg effect[J]. Carcinogenesis,2017,38(2):134-143.
[21]	Jin X,Pan Y,Wang L,et al. MAGE-TRIM28 complex promotes the warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation[J]. Oncogenesis,2017,6(4):1-12.
[22]	Ln Y,Zy N,L W,et al. HSF2 regulates aerobic glycolysis by suppression of FBP1 in hepatocellular carcinoma[J]. American Journal of Cancer Research,2019,9(8):1607-1621.
[23]	Liu G M,Li Q,Zhang P F,et al. Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma[J]. Cell Death Dis,2018,9(11):1132-1141. doi: 10.1038/s41419-018-1165-x
[24]	Zhang D,Li Z,Li T,et al. miR-517a promotes Warburg effect in HCC by directly targeting FBP1[J]. Onco Targets Ther,2018,2018(11):8025-8032.
[25]	Li Q,Wei P,Wu J,et al. The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect[J]. Oncogene,2019,38(4):483-496. doi: 10.1038/s41388-018-0469-8
[26]	Iwatsuki M,Mimori K,Yokobori T,et al. Epithelial-mesenchymal transition in cancer development and its clinical significance[J]. Cancer Science,2010,101(2):293-299. doi: 10.1111/j.1349-7006.2009.01419.x
[27]	Dong C,Yuan T,Wu Y,et al. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer[J]. Cancer Cell,2013,23(3):316-331. doi: 10.1016/j.ccr.2013.01.022
[28]	Li K, Ying M, Feng D, et al. Fructose-1, 6-bisphosphatase is a novel regulator of Wnt/beta-Catenin pathway in breast cancer[J]. Biomed Pharmacother, 2016, 84（期?）: 1144-1149. Li K,Ying M,Feng D,et al. Fructose-1,6-bisphosphatase is a novel regulator of Wnt/beta-Catenin pathway in breast cancer[J]. Biomed Pharmacother,2016,84:1144-1149.
[29]	Shi L,He C,Li Z,et al. FBP1 modulates cell metabolism of breast cancer cells by inhibiting the expression of HIF-1alpha[J]. Neoplasma,2017,64(4):535-542. doi: 10.4149/neo_2017_407
[30]	Fu D,Li J,Wei J,et al. HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer[J]. Cell Commun Signal,2018,16(1):8-17. doi: 10.1186/s12964-018-0219-0
[31]	Shi L,Zhao C,Pu H,et al. FBP1 expression is associated with basal-like breast carcinoma[J]. Oncol Lett,2017,13(5):3046-3056. doi: 10.3892/ol.2017.5860
[32]	Chen J,Lee H-J,Wu X,et al. Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain[J]. Cancer Research,2015,75(3):554-565. doi: 10.1158/0008-5472.CAN-14-2268
[33]	Sheng H,Ying L,Zheng L,et al. Down expression of FBP1 is a negative prognostic factor for non-small-cell lung cancer[J]. Cancer Invest,2015,33(5):197-204. doi: 10.3109/07357907.2015.1020385
[34]	Zhang J,Wang J,Xing H,et al. Down-regulation of FBP1 by ZEB1-mediated repression confers to growth and invasion in lung cancer cells[J]. Mol Cell Biochem,2016,411(1):331-340.
[35]	Dong Y,Huaying S,Danying W,et al. Significance of methylation of FBP1 gene in non-small cell lung cancer[J]. Biomed Res Int,2018,2018(9):1-9.
[36]	Dai Q,Li N,Zhou X. Increased miR-21a provides metabolic advantages through suppression of FBP1 expression in non-small cell lung cancer cells[J]. Am J Cancer Res,2017,7(11):2121-2130.

Relative Articles(20)

Relative Articles

[1]	Qiong WU, Na LI, Yujuan XU. Visual Analysis of Symptom Clusters of Hepatocarcinoma Patients Based on Citespace. Journal of Kunming Medical University, 2024, 45(11): 59-66. doi: 10.12259/j.issn.2095-610X.S20241109
[2]	Haijun WANG, Liangwu QIU, Yanbin XIYANG, Jundi PANG. Research Progress on Aerobic Exercise Intervention for Learning and Memory Ability in Chronic Cerebral Ischemia. Journal of Kunming Medical University, 2024, 45(3): 186-191. doi: 10.12259/j.issn.2095-610X.S20240328
[3]	Yu HUO, Yunhe JU, Yutao WANG, Yalin ZENG, Junfeng LIANG. The Role of DDX46 in the Occurrence And Development of Malignant Tumors. Journal of Kunming Medical University, 2024, 45(11): 161-165. doi: 10.12259/j.issn.2095-610X.S20241123
[4]	Ting LI, Wei-Hua GUO. Research Progress of Glycolytic Reprogramming in Oral Squamous Cell Carcinoma. Journal of Kunming Medical University, 2023, 44(6): 155-161. doi: 10.12259/j.issn.2095-610X.S20230611
[5]	Qun WANG, Yuxin SUN, Haifeng WANG. Research Progress of Perilipin Family of Lipid Droplet Surface Proteins in Cancer. Journal of Kunming Medical University, 2023, 44(8): 139-144. doi: 10.12259/j.issn.2095-610X.S20230812
[6]	Yingbao WANG, Xiaoyun LI, Ying TAN, Meng YANG, Yunqiang SHI, Qinrong PING, Libing HU, Yang YANG, Chunhui WANG. Artemisinin Mediates the Aerobic Glycolysis of Clear Cell Renal Cell Carcinomas via Regulating ENO2. Journal of Kunming Medical University, 2023, 44(11): 9-15. doi: 10.12259/j.issn.2095-610X.S20231102
[7]	Wei ZHANG, Baoquan WANG, Xifeng LEI, Xu WANG, Liang ZHANG. miR-125b-5p Regulates HK2 to Inhibit Proliferation and Glycolysis of Gallbladder Cancer Cells. Journal of Kunming Medical University, 2022, 43(12): 23-29. doi: 10.12259/j.issn.2095-610X.S20221206
[8]	Yi ZENG, Yun-juan LIAO, Ying LI, Zhen-kun HE. Efficacy of Dapagliflozin on Early Diabetic Nephropathy and Its Effect on Serum MCP-1 and IL-6. Journal of Kunming Medical University, 2021, 42(12): 41-46. doi: 10.12259/j.issn.2095-610X.S20211218
[9]	Li Chen , Ma Dong Yan , Li Fei Li , He Min , Yang Na , Mai Xiao Rong , Yang Chun Mei . . Journal of Kunming Medical University, 2020, 41(09): 166-170.
[10]	Jing YANG, Shu-xian WANG, Zhu ZHOU. Effect of Aerobic Exercise and Nutritional Management in Maintenance Hemodialysis Patients with Malnutrition. Journal of Kunming Medical University, 2020, 41(11): 68-71. doi: 10.12259/j.issn.2095-610X.S20201123
[11]	Zhou Ling , Zuo Rui Ling , Ma Li , Yang Yan Yang , Hu Xue Jiao , Xie Lin . . Journal of Kunming Medical University, 2020, 41(04): 142-149.
[12]	Wu Jiang , Wang Yun Hua , Yao Li Qin , Fei Yan Yan , Xie Shan , Shi Tao . . Journal of Kunming Medical University, 2019, 40(06): 62-65.
[13]	Wu Xi , Xu Ting Ting , Shen Li Da , Xie Lin , Hu Feng Di , Long Ting Feng , Dong Jian . . Journal of Kunming Medical University, 2019, 40(10): 77-80.
[14]	Shen Zhi Xiang , Zhu Li Xun , Xu Wei Hong . 有氧运动对2型糖尿病大鼠AGE-RAGE轴及NF-κB通路的影响. Journal of Kunming Medical University, 2018, 39(01): 16-19.
[15]	Zhou Ling , Zhong Qiong , Wang Min , Tan Si , Liu Yong Xiu . Application of Doctor-nurse Integrative Medical Care in Analgesia at Home for Cancer Patients. Journal of Kunming Medical University, 2018, 39(03): 141-144.
[16]	Zhu Yu , He Yi Xiao , Yang Li Juan , Wang Fang . . Journal of Kunming Medical University, 2017, 38(03): 139-142.
[17]	Hu Yu Chong , Lu Jing Kun , Cui Meng Yao . . Journal of Kunming Medical University, 2017, 38(03): 27-30.
[18]	Luo Sai Mei . . Journal of Kunming Medical University,
[19]	Zhang Zhao Li . . Journal of Kunming Medical University,
[20]	Li Dan Na . . Journal of Kunming Medical University,