Epidemiological Analysis of Clinical Isolation of Multi-drug Resistant Bacteria in Children’ s Hospitals

Liqin CHEN; Yaling LI; Xiaojuan LI; Yonghui HAN; Weijie LI

doi:10.12259/j.issn.2095-610X.S20220105

Volume 43 Issue 1

Jan. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(1): 40-47

Liqin CHEN, Yaling LI, Xiaojuan LI, Yonghui HAN, Weijie LI. Epidemiological Analysis of Clinical Isolation of Multi-drug Resistant Bacteria in Children’ s Hospitals[J]. Journal of Kunming Medical University, 2022, 43(1): 40-47. doi: 10.12259/j.issn.2095-610X.S20220105

Citation:

Liqin CHEN, Yaling LI, Xiaojuan LI, Yonghui HAN, Weijie LI. Epidemiological Analysis of Clinical Isolation of Multi-drug Resistant Bacteria in Children’ s Hospitals[J]. Journal of Kunming Medical University, 2022, 43(1): 40-47. doi: 10.12259/j.issn.2095-610X.S20220105

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Epidemiological Analysis of Clinical Isolation of Multi-drug Resistant Bacteria in Children’ s Hospitals

doi: 10.12259/j.issn.2095-610X.S20220105

Dept. of Infection Management，Kunming Children’s Hospital， Kunming Yunnan 650100，China

Received Date: 2021-12-14
Available Online: 2021-12-20
Publish Date: 2022-01-15

Abstract

Abstract

Objective To analyze the distribution and characteristics of multi-drug-resistant bacteria isolated from the clinic in a children’ s hospital, providing the clinical evidence for the prevention and treatment of multi-drug-resistant bacteria in the hospital. Methods A retrospective analysis method was used to collect the data of the top five multi-drug-resistant bacteria of clinically isolated pathogens from inpatients in a children’ s hospital from January 2018 to December 2020, to understand the age, sex, and department distribution in children of multi-drug resistance bacteria, and analyze the drug resistance. Results 1451 strains of multi-drug resistant bacteria were clinically isolated in three years, and the top five were ESBLs-producing Escherichia coli, MRSA, ESBLs-producing Klebsiella pneumoniae, CRAB, and CRKP. The detection rates of ESBLs-producing Escherichia coli, MRSA, and ESBLs-producing Klebsiella pneumoniae were not statistically different in each year （P = 0.163, P = 0.125, P = 0.174）, and the detection rate of CRAB first increased and then decreased （ P < 0.001）, the detection rate of CRKP was decreasing year by year （P = 0.001）. The majority of children with multi-drug-resistant bacteria were boys （55.4%） and infants （43.6%）. The department with the highest detection rate was neurosurgery, with 9.18%, followed by burn plastic surgery, with a detection rate of 4.32%; specimen types had the highest positive rate of secretion, which was 7.06%. The main type of specimens was sputum （52.3%）. The drug sensitivity results showed that the resistance rates of ESBLs-producing Escherichia coli to penicillins, cefazolin and ceftriaxone were greater than 99%. The resistance rate of MRSA to penicillins was 100%, and the resistance rates to vancomycin, linezolid, tigecycline were all 0.0%. The resistance rates of ESBLs-producing Klebsiella pneumoniae to penicillins, cefazolin and ceftriaxone were 100.0%. In 2018, the resistance rate of Acinetobacter baumannii to meropenem was 16.7%, and the resistance rates to the other 13 antibacterial drugs were all 100.0%. In 2019 and 2020, The resistance rates of Acinetobacter baumannii to nitrofurantoin, cefazolin, ampicillin were 100.0%, and the resistance rates to other antibiotics were lower than those in 2018. The resistance rates of CRKP to penicillins, cephalosporins and carbapenem antibiotics were above 90.0%. Conclusion In recent years, the situation of multi-drug resistant bacteria in children’ s hospitals has been severe. The management of the rational use of clinical antimicrobials should be strengthened to reduce the occurrence of drug-resistant bacteria.
- Children’ s hospital,
- Multi-drug resistant bacteria,
- Epidemiology

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