The Effect of Bronchoscopic Alveolar Lavage on the Maintenance of Borderline Donor Lung in Brain Death

Lingming GONG; Li LI; Jianghua RAN; Lan LI; Shengning ZHANG; Chao LI; Yinjia WANG; Dongkun WANG; Li ZHENG; Guofeng ZHANG

doi:10.12259/j.issn.2095-610X.S20220107

Volume 43 Issue 1

Jan. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(1): 89-95

Lingming GONG, Li LI, Jianghua RAN, Lan LI, Shengning ZHANG, Chao LI, Yinjia WANG, Dongkun WANG, Li ZHENG, Guofeng ZHANG. The Effect of Bronchoscopic Alveolar Lavage on the Maintenance of Borderline Donor Lung in Brain Death[J]. Journal of Kunming Medical University, 2022, 43(1): 89-95. doi: 10.12259/j.issn.2095-610X.S20220107

Citation:

Lingming GONG, Li LI, Jianghua RAN, Lan LI, Shengning ZHANG, Chao LI, Yinjia WANG, Dongkun WANG, Li ZHENG, Guofeng ZHANG. The Effect of Bronchoscopic Alveolar Lavage on the Maintenance of Borderline Donor Lung in Brain Death[J]. Journal of Kunming Medical University, 2022, 43(1): 89-95. doi: 10.12259/j.issn.2095-610X.S20220107

Citation:

Lingming GONG, Li LI, Jianghua RAN, Lan LI, Shengning ZHANG, Chao LI, Yinjia WANG, Dongkun WANG, Li ZHENG, Guofeng ZHANG. The Effect of Bronchoscopic Alveolar Lavage on the Maintenance of Borderline Donor Lung in Brain Death[J]. Journal of Kunming Medical University, 2022, 43(1): 89-95. doi: 10.12259/j.issn.2095-610X.S20220107

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The Effect of Bronchoscopic Alveolar Lavage on the Maintenance of Borderline Donor Lung in Brain Death

doi: 10.12259/j.issn.2095-610X.S20220107

1.
Dept. of Cardiothoracic Surgery
2.
Dept. of Hepatological Surgery
3.
Dept. of Ophthalmology
4.
Dept. of Intensive Care Unit，The 1st People’s Hospital of Kunming，Kunming Yunnan 650011
5.
Dept. of Thoracic Surgery，The 1st People’s Hospital of Qujing， Qujing Yunnan 655000，China

Received Date: 2021-11-22
Publish Date: 2022-01-15

Abstract

Abstract

Objective To investigate the effect of bronchoscopic alveolar lavage on the maintenance of borderline donor lung in brain death. Methods The brain death patients meeting the inclusion criteria and admitted to Ganmei Hospital of Kunming Medical University from September 2017 to December 2019 were randomly divided into the fiberoptic bronchoscopy alveolar lavage group （experimental group） and the control group on the basis of routine maintenance. Statistical analysis was carried out through the comparison of chest film, arterial blood gas （oxygenation index）, fiberoptic bronchoscopy and other indexes between the two groups. Result The scores of oxygenation index, chest radiograph and fiberbronchoscope performance of the two groups after the experiment were all lower than those before the experiment the differences were statistically significant （P < 0.05）, and there was statistically significant difference in effective rate between the two groups （P < 0.05）. The effective rate of the experimental group was higher than that of the control group. Conclusion Fiberbronchoscope alveolar lavage can be used as an effective technique to maintain the donor lung and has a wide application prospect.
- Lung transplantation,
- Brain death,
- Marginal donor lung,
- Bronchoalveolar lavage,
- Maintenance of donor lung

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References(22)

References

[1]	陈静瑜,毛文君,马千里,等. 中国肺移植供体标准及获取转运指南[J]. 器官移植,2018,9(5):325-333. doi: 10.3969/j.issn.1674-7445.2018.05.001
[2]	徐龙明,左云霞,林一丹. 肺移植研究现状及移植期的规范化管理[J]. 中国胸心血管外科临床杂志,2020,27(2):209-213.
[3]	郭明晓,李幼生. 脑死亡供体器官研究进展[J]. 中国普外基础与临床杂志,2013,20(10):1183-1187.
[4]	高彤彤,田慧. 公民逝世后器官捐献供体评估、维护及护理[J]. 实用器官移植电子杂志,2017,5(1):31-33. doi: 10.3969/j.issn.2095-5332.2017.01.011
[5]	Kotloff R M,Blosser S,Fulda G J,et al. Management of the potential organ donor in the ICU:Society of critical care medicine/American college of chest physicians/association of organ procurement organizations consensus statement[J]. Critical Care Medicine,2015,43(6):1291-1325. doi: 10.1097/CCM.0000000000000958
[6]	Bittner H B,Kendall S W,Campbell K A,et al. A valid experimental brain death donor model[J]. J Heart Lung Transplant,1995,14(2):308-317.
[7]	Viemann D,Strey A,Janning A,et al. Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells[J]. Blood,2005,105(7):2955-2962. doi: 10.1182/blood-2004-07-2520
[8]	Apostolakis E,Parissis H,Dougenis D. Brain death and donor heart dysfunction:Implications in cardiac transplantation[J]. J Card Surg,2010,25(1):98-106. doi: 10.1111/j.1540-8191.2008.00790.x
[9]	Zweers N,Petersen A H,van der Hoeven J A,et al. Donor brain death aggravates chronic rejection after lung transplantation in rats[J]. Transplantation,2004,78(9):1251-1258. doi: 10.1097/01.TP.0000142679.45418.96
[10]	Murray J F,Matthay M A,Luce J M,et al. An expanded definition of the adult respiratory distress syndrome[J]. Am Rev Respir Dis,1988,138(3):720-723. doi: 10.1164/ajrccm/138.3.720
[11]	Oto T,Levvey B J,Whitford H,et al. Feasibility and utility of a lung donor score:Correlation with early post-transplant outcomes[J]. Ann Thorac Surg,2007,83(1):257-63.
[12]	蔡兴俊,黄奕江,付姣,等. 急性肺损伤患者肺损伤评分与AGEs在预后评价中的作用[J]. 海南医学院学报,2013,19(2):186-188.
[13]	Dimopoulou I,Tsagarakis S,Anthi A,et al. High prevalence of decreased cortisol reserve in brain-dead potential organ donors[J]. Crit Care Med,2003,31(4):1113-1117. doi: 10.1097/01.CCM.0000059644.54819.67
[14]	孙振涛,韩雪萍,苗丽君,等. 脑死亡状态巴马小型猪肺水含量及肺超微结构变化[J]. 中国组织工程研究与临床康复,2007,8(9):1428-1430.
[15]	窦晓婧,王清平. 炎性反应对脑死亡供体器官影响的研究进展[J]. 实用器官移植电子杂志,2016,4(5):315-318. doi: 10.3969/j.issn.2095-5332.2016.05.013
[16]	Mascia L,Pasero D,Slutsky A S,et al. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation:A randomized controlled trial[J]. JAMA,2010,304(23):2620-2627. doi: 10.1001/jama.2010.1796
[17]	吴波,冯靖,张静,等. 诊断性介入肺脏病学取材联合病原微生物宏基因组测序在肺部感染应用的原则[J]. 天津医药,2019,47(4):368-370. doi: 10.11958/20190835
[18]	钟南山, 刘又宁. 呼吸病学[M]第2版. 北京: 人民卫生出版社, 2017: 857-859.
[19]	李建辉,乔银标,贾俊君,等. 推动体外器官灌注技术发展,提高捐献器官利用率及质量[J]. 中华移植杂志(电子版),2020,14(2):83-86. doi: 10.3877/cma.j.issn.1674-3903.2020.02.005
[20]	Timek T,Vahl C F,Bonz A,et al. Triiodothyronine reverses depressed contractile performance after excessive catecholamine stimulation[J]. Ann Thorac Surg,1998,66(5):1618-1625. doi: 10.1016/S0003-4975(98)00764-4
[21]	邓兴,吴生坚,胡金金,等. 纤维支气管镜ICU治疗严重肺部感染中的应用意义探析[J]. 中外医疗,2016,35(29):103-105.
[22]	刘东,毛文君,叶书高,等. 中国肺移植供肺获取与保护技术规范(2019版)[J]. 中华移植杂志(电子版),2019,13(2):87-90. doi: 10.3877/cma.j.issn.1674-3903.2019.02.002

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