Clinical Characteristics, Diagnosis and Treatment of Diabetes Mellitus with Pulmonary Mucormycosis

Yanli LI; Liqiong LIU; Dailing Yan; Yaji YANG; YANGFang; YANG ShengRong OU; Yanhong LIU

doi:10.12259/j.issn.2095-610X.S20220108

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Yanli LI, Liqiong LIU, Dailing Yan, Yaji YANG, YANGFang, YANG ShengRong OU, Yanhong LIU. Clinical Characteristics, Diagnosis and Treatment of Diabetes Mellitus with Pulmonary Mucormycosis[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S20220108

Citation:

Yanli LI, Liqiong LIU, Dailing Yan, Yaji YANG, YANGFang, YANG ShengRong OU, Yanhong LIU. Clinical Characteristics, Diagnosis and Treatment of Diabetes Mellitus with Pulmonary Mucormycosis[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S20220108

Citation:

Yanli LI, Liqiong LIU, Dailing Yan, Yaji YANG, YANGFang, YANG ShengRong OU, Yanhong LIU. Clinical Characteristics, Diagnosis and Treatment of Diabetes Mellitus with Pulmonary Mucormycosis[J]. Journal of Kunming Medical University. doi: 10.12259/j.issn.2095-610X.S20220108

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Clinical Characteristics, Diagnosis and Treatment of Diabetes Mellitus with Pulmonary Mucormycosis

doi: 10.12259/j.issn.2095-610X.S20220108

1.
The 1st Department. of Pulmonary and Critical Care Medicine
2.
Dept. of Pathology，Yan’an Hospital Affiliated to Kunming Medical University，Kunming Yunnan　650051，China

Received Date: 2021-11-16

Abstract

Abstract

Objective To explore the risk factors, clinical symptoms, diagnosis and treatment of pulmonary mucormycosis （PM） so as to improve the diagnostic rate of PM and reduce the mortality. Methods 4 patients （2 females and 2 males） with pulmonary mucormycosis confirmed by pathology in the First Department of Respiratory and Critical Care Medicine of Yan'an Hospital of Kunming City from January 2011 to August 2021 were collected and their clinical data, risk factors, clinical symptoms, imaging findings, treatment and prognosis were analyzed. Results All 4 patients were complicated with type 2 diabetes, 1 patient with hypertension, 1 patient with chronic renal failure and was treated with long-term oral hormone therapy. The main chest imaging findings were mainly patchy, patchy high-density shadows and bronchial lumen stenosis. All the 4 patients were diagnosed as PM by pathological biopsy. After the diagnosis, 1 patient died of massive hemoptysis, 2 patients were treated with systemic antifungal drugs combined with bronchoscopic intervention and 1 patient was treated with bronchoscopic intervention due to intolerance to systemic antifungal therapy. The clinical symptoms of the 3 patients were improved significantly after the treatment. Conclusion PM is a rare invasive fungal disease, which occurs frequently in patients with diabetes, renal failure and immune deficiency. The clinical symptoms are lack of specificity, and the diagnosis mainly depends on the etiology and histological examination. Our clinical experience suggests that antifungal drugs combined with bronchoscopic interventional therapy can improve the outcomes of patients with PM, but further expanded sample size is still needed to observe the efficacy of the treatment.
- Pulmonary mucormycosis,
- Clinical characteristics,
- Treatment

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