Research Progress of Exosomes-derived Long Non-coding RNA in Bladder Cancer

Jun GU; Zexi HE; Ting LUAN; Haifeng WANG; Jiansong WANG; Mingxia DING

doi:10.12259/j.issn.2095-610X.S20220110

Volume 43 Issue 1

Jan. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(1): 150-156

Jun GU, Zexi HE, Ting LUAN, Haifeng WANG, Jiansong WANG, Mingxia DING. Research Progress of Exosomes-derived Long Non-coding RNA in Bladder Cancer[J]. Journal of Kunming Medical University, 2022, 43(1): 150-156. doi: 10.12259/j.issn.2095-610X.S20220110

Citation:

Jun GU, Zexi HE, Ting LUAN, Haifeng WANG, Jiansong WANG, Mingxia DING. Research Progress of Exosomes-derived Long Non-coding RNA in Bladder Cancer[J]. Journal of Kunming Medical University, 2022, 43(1): 150-156. doi: 10.12259/j.issn.2095-610X.S20220110

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Research Progress of Exosomes-derived Long Non-coding RNA in Bladder Cancer

doi: 10.12259/j.issn.2095-610X.S20220110

Dept. of Urology，The 2nd Affiliated Hospital of Kunming Medical University， Yunnan Institute of Urology，Kunming Yunnan 650101，China

Received Date: 2021-10-07
Available Online: 2021-12-20
Publish Date: 2022-01-15

Abstract

Abstract

Bladder cancer is one of the most common urinary tumors with the high morbidity and recurrence rate. It is of great clinical value to develop a non-invasive detection technique with the high sensitivity and specificity in vitro for the diagnosis and treatment of bladder cancer. Exosomes are extracellular vesicles secreted by many cells and play a key role in intercellular communication by delivering intracellular signaling substances （such as proteins, nucleic acids, non-coding RNAs, etc.）. More and more studies have shown that exosomes-derived long non-coding RNA plays an important regulatory role in the development and progression of bladder cancer and can effectively reflect the progression and prognosis of tumors, which is expected to become a new tumor marker. Therefore, this paper reviews the research progress of exosomes-derived long non-coding RNA in the development and diagnosis of bladder cancer.
- Exosomes,
- Long non-coding RNA,
- Bladder cancer

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References(50)

References

[1]	Kelly J D,Tan W S,Porta N,et al. BOXIT-A randomised phase III placebo-controlled trial evaluating the addition of celecoxib to standard treatment of transitional cell carcinoma of the bladder (CRUK/07/004)[J]. Eur Urol,2019,75(4):593-601. doi: 10.1016/j.eururo.2018.09.020
[2]	Tan W S,Tan W P,Tan M Y,et al. Novel urinary biomarkers for the detection of bladder cancer:A systematic review[J]. Cancer Treat Rev,2018,69(3):39-52.
[3]	Babjuk M,Bohle A,Burger M,et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder:Update 2016[J]. Eur Urol,2017,71(3):447-461. doi: 10.1016/j.eururo.2016.05.041
[4]	Kamat A M,Hahn N M,Efstathiou J A,et al. Bladder cancer[J]. Lancet,2016,388(10061):2796-2810. doi: 10.1016/S0140-6736(16)30512-8
[5]	Lokeshwar V B, Habuchi T, Grossman H B, et al. Bladder tumor markers beyond cytology: International consensus panel on bladder tumor markers[J]. Urology, 2005, 66（6 Suppl 1）: 35-63.
[6]	Chao D,Freedland S J,Pantuck A J,et al. Bladder cancer 2000:Molecular markers for the diagnosis of transitional cell carcinoma[J]. Rev Urol,2001,3(2):85-93.
[7]	Nabet B Y, Qiu Y, Shabason J E, et al. Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer[J]. Cell, 2017, 170（2）: 352-366 e313.
[8]	Jiang L,Vader P,Schiffelers R M. Extracellular vesicles for nucleic acid delivery:Progress and prospects for safe RNA-based gene therapy[J]. Gene Ther,2017,24(3):157-166. doi: 10.1038/gt.2017.8
[9]	Navakanitworakul R,Hung W T,Gunewardena S,et al. Characterization and small RNA content of extracellular vesicles in follicular fluid of developing bovine antral follicles[J]. Sci Rep,2016,6(9):25486.
[10]	Tkach M,Thery C. Communication by extracellular vesicles:Where we are and where we need to go[J]. Cell,2016,164(6):1226-1232. doi: 10.1016/j.cell.2016.01.043
[11]	Li M,Zeringer E,Barta T,et al. Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers[J]. Philos Trans R Soc Lond B Biol Sci,2014,369(1652):20130502. doi: 10.1098/rstb.2013.0502
[12]	Zhou W,Fong M Y,Min Y,et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis[J]. Cancer Cell,2014,25(4):501-515. doi: 10.1016/j.ccr.2014.03.007
[13]	Yang L,Wu X H,Wang D,et al. Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro[J]. Mol Med Rep,2013,8(4):1272-1278. doi: 10.3892/mmr.2013.1634
[14]	Xu X D,Wu X H,Fan Y R,et al. Exosome-derived microRNA-29c induces apoptosis of BIU-87 cells by down regulating BCL-2 and MCL-1[J]. Asian Pac J Cancer Prev,2014,15(8):3471-3476. doi: 10.7314/APJCP.2014.15.8.3471
[15]	Beckham C J,Olsen J,Yin P N,et al. Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression[J]. J Urol,2014,192(2):583-592. doi: 10.1016/j.juro.2014.02.035
[16]	Ringuette Goulet C,Bernard G,Tremblay S,et al. Exosomes induce fibroblast differentiation into cancer-associated fibroblasts through TGFβ signaling[J]. Mol Cancer Res,2018,16(7):1196-1204. doi: 10.1158/1541-7786.MCR-17-0784
[17]	Franzen C A,Blackwell R H,Todorovic V,et al. Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes[J]. Oncogenesis,2015,4(8):e163. doi: 10.1038/oncsis.2015.21
[18]	Goulet C R,Champagne A,Bernard G,et al. Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling[J]. BMC Cancer,2019,19(1):137. doi: 10.1186/s12885-019-5353-6
[19]	Shan G,Zhou X,Gu J,et al. Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/beta-catenin pathway and upregulating PTEN[J]. Cell Oncol (Dordr),2021,44(1):45-59. doi: 10.1007/s13402-020-00500-0
[20]	Jeppesen D K,Nawrocki A,Jensen S G,et al. Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors[J]. Proteomics,2014,14(6):699-712. doi: 10.1002/pmic.201300452
[21]	Pan J,Li X,Wu W,et al. Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells[J]. Cancer Lett,2016,382(1):64-76. doi: 10.1016/j.canlet.2016.08.015
[22]	Yang C,Li X,Wang Y,et al. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells[J]. Gene,2012,496(1):8-16. doi: 10.1016/j.gene.2012.01.012
[23]	Wang X,Gong Y,Jin B,et al. Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells[J]. Oncol Rep,2014,32(3):1281-1290. doi: 10.3892/or.2014.3309
[24]	Wang X-S,Zhang Z,Wang H-C,et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma[J]. Clin Cancer Res,2006,12(16):4851-4858. doi: 10.1158/1078-0432.CCR-06-0134
[25]	Wang F,Li X,Xie X,et al. UCA1,a non-protein-coding RNA up-regulated in bladder carcinoma and embryo,influencing cell growth and promoting invasion[J]. FEBS Lett,2008,582(13):1919-1927. doi: 10.1016/j.febslet.2008.05.012
[26]	Xue M,Chen W,Xiang A,et al. Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1[J]. Mol Cancer,2017,16(1):143. doi: 10.1186/s12943-017-0714-8
[27]	Xue M,Pang H,Li X,et al. Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway[J]. Cancer Sci,2016,107(1):18-27. doi: 10.1111/cas.12844
[28]	Zheng R,Du M,Wang X,et al. Exosome-transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression[J]. Mol Cancer,2018,17(1):143. doi: 10.1186/s12943-018-0880-3
[29]	Huang C S,Ho J Y,Chiang J H,et al. Exosome-derived LINC00960 and LINC02470 promote the epithelial-mesenchymal transition and aggressiveness of bladder cancer cells[J]. Cells,2020,9(6):1419. doi: 10.3390/cells9061419
[30]	Yan L,Wang P,Fang W,et al. Cancer-associated fibroblasts-derived exosomes-mediated transfer of LINC00355 regulates bladder cancer cell proliferation and invasion[J]. Cell Biochem Funct,2020,38(3):257-265. doi: 10.1002/cbf.3462
[31]	He W,Zhong G,Jiang N,et al. Long noncoding RNA BLACAT2 promotes bladder cancer-associated lymphangiogenesis and lymphatic metastasis[J]. J Clin Invest,2018,128(2):861-875. doi: 10.1172/JCI96218
[32]	Chen C,He W,Huang J,et al. LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment[J]. Nat Commun,2018,9(1):3826. doi: 10.1038/s41467-018-06152-x
[33]	Chen C,Luo Y,He W,et al. Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer[J]. J Clin Invest,2020,130(1):404-421.
[34]	Ren H,Yang X,Yang Y,et al. Upregulation of LncRNA BCYRN1 promotes tumor progression and enhances EpCAM expression in gastric carcinoma[J]. Oncotarget,2017,9(4):4851-4861.
[35]	Huo W,Qi F,Wang K. Long non-coding RNA BCYRN1 promotes prostate cancer progression via elevation of HDAC11[J]. Oncol Rep,2020,44(3):1233-1245.
[36]	Lang N,Wang C,Zhao J,et al. Long non-coding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR-149/PKM2 axis in non-small-cell lung cancer[J]. Mol Med Rep,2020,21(3):1509-1516.
[37]	Yu J H,Chen Y. Clinical significance of lncRNA BCYRN1 in colorectal cancer and its role in cell metastasis[J]. Eur Rev Med Pharmacol Sci,2019,23(21):9371-9378.
[38]	Ghafouri Fard S,Dashti S,Hussen B M,et al. BCYRN1:An oncogenic lncRNA in diverse cancers[J]. Pathol Res Pract,2021,220(4):153385.
[39]	Zheng H,Chen C,Luo Y,et al. Tumor-derived exosomal BCYRN1 activates WNT5A/VEGF-C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer[J]. Clin Transl Med,2021,11(7):e497.
[40]	Luo G,Zhang Y,Wu Z,et al. Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistance to cisplatin by regulating miR-34b-5p/ABCB1 axis[J]. Acta Biochim Biophys Sin (Shanghai),2021,53(5):558-566. doi: 10.1093/abbs/gmab023
[41]	Crowley E,Di Nicolantonio F,Loupakis F,et al. Liquid biopsy:monitoring cancer-genetics in the blood[J]. Nat Rev Clin Oncol,2013,10(8):472-484. doi: 10.1038/nrclinonc.2013.110
[42]	Su Q,Wu H,Zhang Z,et al. Exosome-Derived Long Non-Coding RNAs as Non-Invasive Biomarkers of Bladder Cancer[J]. Front Oncol,2021,11(15):719863.
[43]	Li W X,Zhang Y L. Novel long non-coding RNA markers for prognostic prediction of patients with bladder cancer[J]. Chin Med Sci J,2020,35(3):239-247. doi: 10.24920/003662
[44]	Zhang S,Du L,Wang L,et al. Evaluation of serum exosomal LncRNA-based biomarker panel for diagnosis and recurrence prediction of bladder cancer[J]. J Cell Mol Med,2019,23(2):1396-1405. doi: 10.1111/jcmm.14042
[45]	Zhan Y,Du L,Wang L,et al. Expression signatures of exosomal long non-coding RNAs in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer[J]. Mol Cancer,2018,17(1):142. doi: 10.1186/s12943-018-0893-y
[46]	Yazarlou F,Modarressi M H,Mowla S J,et al. Urinary exosomal expression of long non-coding RNAs as diagnostic marker in bladder cancer[J]. Cancer Manag Res,2018,10(22):6357-6365.
[47]	Abbastabar M,Sarfi M,Golestani A,et al. Tumor-derived urinary exosomal long non-coding RNAs as diagnostic biomarkers for bladder cancer[J]. EXCLI J,2020,19(1):301-310.
[48]	Wang J,Gao Y,Wang X,et al. Circulating lncRNAs as noninvasive biomarkers in bladder cancer:A diagnostic meta-analysis based on 15 published articles[J]. Int J Biol Markers,2020,35(2):40-48. doi: 10.1177/1724600820926685
[49]	Wang J,Yang K,Yuan W,et al. Determination of serum exosomal H19 as a noninvasive biomarker for bladder cancer diagnosis and prognosis[J]. Med Sci Monit,2018,24(12):9307-9316.
[50]	Berrondo C,Flax J,Kucherov V,et al. Expression of the long non-coding RNA HOTAIR correlates with disease progression in bladder cancer and is contained in bladder cancer patient urinary exosomes[J]. PLoS One,2016,11(1):e0147236. doi: 10.1371/journal.pone.0147236

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