The Correlation between The Thyroid Function and Renal Function in Patients with Differentiated Thyroid Cancer under the Short-term Hypothyroidism after Withdrawal of Iodine Therapy

Feipeng WU; Yongqiang GAO; Liju HONG; Qiyan WU; Huijun CHENG; Jiaoxia LI; Youjun ZHOU; Xiandong ZHENG

doi:10.12259/j.issn.2095-610X.S20220128

Volume 43 Issue 1

Jan. 2022

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Feipeng WU, Yongqiang GAO, Liju HONG, Qiyan WU, Huijun CHENG, Jiaoxia LI, Youjun ZHOU, Xiandong ZHENG. The Correlation between The Thyroid Function and Renal Function in Patients with Differentiated Thyroid Cancer under the Short-term Hypothyroidism after Withdrawal of Iodine Therapy[J]. Journal of Kunming Medical University, 2022, 43(1): 77-83. doi: 10.12259/j.issn.2095-610X.S20220128

Citation:

Feipeng WU, Yongqiang GAO, Liju HONG, Qiyan WU, Huijun CHENG, Jiaoxia LI, Youjun ZHOU, Xiandong ZHENG. The Correlation between The Thyroid Function and Renal Function in Patients with Differentiated Thyroid Cancer under the Short-term Hypothyroidism after Withdrawal of Iodine Therapy[J]. Journal of Kunming Medical University, 2022, 43(1): 77-83. doi: 10.12259/j.issn.2095-610X.S20220128

Citation:

Feipeng WU, Yongqiang GAO, Liju HONG, Qiyan WU, Huijun CHENG, Jiaoxia LI, Youjun ZHOU, Xiandong ZHENG. The Correlation between The Thyroid Function and Renal Function in Patients with Differentiated Thyroid Cancer under the Short-term Hypothyroidism after Withdrawal of Iodine Therapy[J]. Journal of Kunming Medical University, 2022, 43(1): 77-83. doi: 10.12259/j.issn.2095-610X.S20220128

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The Correlation between The Thyroid Function and Renal Function in Patients with Differentiated Thyroid Cancer under the Short-term Hypothyroidism after Withdrawal of Iodine Therapy

doi: 10.12259/j.issn.2095-610X.S20220128

1.
Dept. of Nuclear Medicine, The Affiliated Yan’an Hospital of Kunming Medical University，Kunming Yunnan，650051
2.
Dept. of Nuclear Medicine，The Affiliated Pu’er Hospital of Kunming University of Science and Technology，Pu’er Yunnan 665000，China

Received Date: 2021-12-14
Available Online: 2021-12-20
Publish Date: 2022-01-15

Abstract

Abstract

Objectives To investigate the correlation between the thyroid function and renal function in patients with the differentiated thyroid cancer in the short-term hypothyroid state after the discontinuation of prior radioiodine therapy. Methods A total of 122 patients with the differentiated thyroid cancer and operated on and suitable for radioiodine therapy were included. The data of thyroid function level and renal function level before and after the withdrawal of levothyroxine in enrolled patients were collected. The changes in renal function measures before versus after the discontinuation were compared and the thyroid function and associated factors on renal function were analyzed. Results The levels of uric acid, creatinine, and eGFR in patients with DTC increased after the treatment discontinuation compared with those before the treatment discontinuation; In the hypothyroid state after the drug withdrawal, male patients had the higher levels of creatinine and uric acid than female patients. The level of creatinine in TSH > 60 miu/l group was higher than that in TSH ≤ 60 miu/l group, and the level of EGFR in TSH > 60 miu/l group was lower than that in TSH ≤ 60 miu/l group. There was no significant difference in biochemical indexes of renal function between cervical lymph node metastasis group and non cervical lymph node metastasis group, total thyroidectomy group and subtotal thyroidectomy group （P > 0.05）; The levels of FT4, TT3 and TT4 were positively correlated with the level of EGFR （r value was 0.267, 0.249 and 0.330, P < 0.05）, age was negatively correlated with the level of EGFR （r value was -0.213, P < 0.05）, and TT4 was negatively correlated with the level of creatinine （r value was -0.232, P < 0.05）; Multiple linear regression showed that TT4 level, age and gender were independently correlated with EGFR level. Conclusion For DTC patients in hypothyroidism after the withdrawal before the radioactive iodine treatment, the levels of uric acid and creatinine increase and the level of eGFR decreases; the reduced TT4 level, old age and male are the independent influencing factors for the decrease of eGFR level.
- Differentiated thyroid carcinoma,
- Hypothyroidism,
- Glomerular filtration rate

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