Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming

Tingting YU; Dongling LI; Hongying WANG; Lihua LI; Dong PU; Kunli WU

doi:10.12259/j.issn.2095-610X.S20220133

Volume 43 Issue 1

Jan. 2022

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Tingting YU, Dongling LI, Hongying WANG, Lihua LI, Dong PU, Kunli WU. Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming[J]. Journal of Kunming Medical University, 2022, 43(1): 138-143. doi: 10.12259/j.issn.2095-610X.S20220133

Citation:

Tingting YU, Dongling LI, Hongying WANG, Lihua LI, Dong PU, Kunli WU. Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming[J]. Journal of Kunming Medical University, 2022, 43(1): 138-143. doi: 10.12259/j.issn.2095-610X.S20220133

Citation:

Tingting YU, Dongling LI, Hongying WANG, Lihua LI, Dong PU, Kunli WU. Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming[J]. Journal of Kunming Medical University, 2022, 43(1): 138-143. doi: 10.12259/j.issn.2095-610X.S20220133

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Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming

doi: 10.12259/j.issn.2095-610X.S20220133

Clinical Laboratory，The Thid People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2021-12-10
Available Online: 2021-12-20
Publish Date: 2022-01-15

Abstract

Abstract

Objective To investigate the infection, immunity, and drug resistance of newly-treated HIV cases in Kunming. The clinical characteristics and virological characteristics were jointly analyzed, so as to provide a basis to determine the ease of treatment and individualized solutions for antiviral precision treatment. Method The HIV-RNA , HCV-RNA, HBV-DNA, CD4 cell count, ALT, AST, Hb, PLT, ALB, HIV typing and resistance testing in 200 cases of newly-treated cases of HIV were detected before the therapy. Result The mainly infection route of newly-treated cases of HIV in Kunming was the heterosexual transmission, accounting for 80.5%, and MSM people also occupied a certain proportion （6.5%）. Youth and seniors accounted for 25%. CD4 level was negatively correlated with viral load in newly-treated cases of HIV in Kunming （r = -0.58, P < 0.05）, and 83 cases of them suffered from the opportunistic concurrent infection. HIV subtype had the highest proportion with CRF08_BC subtype in newly-treated cases of HIV in Kunming （27.5%）. A total of 7 infected persons were detected resistance mutation sites in 200 newly-treated cases of HIV in Kunming. Primary resistance rate was 3.5%. Conclusion New features of HIV spreading in Kunming have emerged. The route of transmission has changed from intravenous drug use to heterosexual transmission. Increasing proportion of MSM population, adolescents and the Elderly. HIV subtypes have unique distribution characteristics in Kunming. The overall immune status is low. Primary resistance rate is 3.5%.
- HIV,
- Newly-treated,
- Infection,
- Immunity,
- Drug resistance

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