Rui CUN, Meiling CHEN. Efficacy and Clinical Application of Flunarizine Combined with Ginkgo damo in Treatment of Senile Vertigo[J]. Journal of Kunming Medical University, 2022, 43(7): 116-120. doi: 10.12259/j.issn.2095-610X.S20220703
Citation: Chongxi LI, Guangfeng YIN, Yushu ZHANG, Shanqun GU, Wei ZHANG, Jun LIU, Bo TIAN. Prevalence of Kidney Disease among Pre-ART Patients with HIV Infection in Kunming and The Influencing Factors[J]. Journal of Kunming Medical University, 2022, 43(2): 154-159. doi: 10.12259/j.issn.2095-610X.S20220208

Prevalence of Kidney Disease among Pre-ART Patients with HIV Infection in Kunming and The Influencing Factors

doi: 10.12259/j.issn.2095-610X.S20220208
  • Received Date: 2021-12-23
    Available Online: 2022-02-24
  • Publish Date: 2022-03-04
  •   Objective  To investigate the prevalence and characteristics of nephropathy in HIV infected patients before antiviral treatment, and to analyze the related factors of nephropathy before antiviral treatment.  Methods  Patients with HIV infection who visited the Third People’ s Hospital of Kunming from June 2019 to March 2021 were recruited and screened by urine analysis, serum creatinine, urine microalbumin-to-creatinine ratios, urinary α1 microglobulin, and renal ultrasound. And all patients were screened by triglyceride, total serum cholesterol, fasting plasma glucose test . Body mass index was measured.Demographic data , medical history of hypertension and diabetes were collected. SPSS17.0 was used for univariate analysis and logistic regression analysis.  Results  The mean age of 468 subjects was 43.42±14.66 years. The male to female ratio was 1.96. The mean body mass index was 21.73±3.76. Body mass index ≥25 accounted for 15% of all the subjects . Some patients smoked daily which accounted for 33.3% of all the subjects. Patients with hypertriglyceridemia, hypertension and diabetes accounted for 24.7%, 10.7%, 7.7% respectively. And 21.8% of patients were taking drugs which were not antiretroviral therapy. The detection rate of kidney disease in total of 468 cases was 20.7%. the CKD-EPI formula was used to calculate and estimate glomerular filtration rate (eGFR). Patients with eGFR < 60 mL/min/1.73 m2, 60~90 mL/min/1.73 m2, ≥ 90 mL/min/1.73 m2 accounted for 1.1%, 9.6%, 89.3% respectively. The positivity rate of urinary protein was 3.1%, which measured just only by urine analysis. The urinary microalbumin/creatinine ratio (ACR) ≥ 30 mg/gCr were occurred in 24/111 cases (21.6%). The Urinary α1 microglobulin ≥ 12.5 mg/L were occurred in 71/111 cases (63.9%). Multivariate analysis indicated the independent effects of the age ≥ 50 years (OR = 2.285, P = 0.002), body mass index ≥25 (OR = 2.029, P = 0.025), hypertension (OR = 2.334, P = 0.017), diabetes (OR = 2.634, P = 0.014), HIV viral load ≥1×105 copies /mL (OR = 2.296, P = 0.002), which significantly associated with kidney disease. Female is a protective factor for kidney disease in HIV infected persons before antiviral therapy.   Conclusions  The detection rate of kidney disease is high and mainly abnormal urinary protein in Kunming area.Gender, age, hypertension, diabetes, body mass index and HIV viral load are significantly associated with the kidney disease in HIV patients before antiviral treatment. When screening for kidney disease, it is recommended to fully evaluate the results with urine analysis, serum creatinine, renal ultrasound, urinary microalbumin/creatinine ratio, and urinary α1 microglobulin.
  • [1]
    Adih W K,Selik R M,Hu X. Trends in Diseases Reported on US Death Certificates That Mentioned HIV Infection,1996-2006[J]. J Int Assoc Physicians AIDS Care (Chic),2011,10(1):5-11. doi: 10.1177/1545109710384505
    [2]
    Zhang L,Wang F,Wang L,et al. Prevalence of chronic kidney disease in China:a cross-sectional survey[J]. Lancet,2012,379(9818):815-822. doi: 10.1016/S0140-6736(12)60033-6
    [3]
    Cao Y,Gong M,Han Y,et al. Prevalence and risk factors for chronic kidney disease among HIV-infected antiretroviral therapy-naïve patients in Mainland of China:a multicenter cross-sectional study[J]. Nephrology (Carlton),2013,18(4):307-312. doi: 10.1111/nep.12031
    [4]
    Stevens P E,Levin A. Kidney disease:improving global outcomes chronic kidney disease guideline development work group members. evaluation and management of chronic kidney disease:synopsis of the kidney disease:improving global outcomes 2012 clinical practice guideline[J]. Ann Intern Med,2013,158(11):825-830. doi: 10.7326/0003-4819-158-11-201306040-00007
    [5]
    Levey A S,Stevens L A,Schmid C H,et al. A new equation to estimate glomerular filtration rate[J]. Ann Intern Med,2009,150(9):604-612. doi: 10.7326/0003-4819-150-9-200905050-00006
    [6]
    Shen Y,Wang J,Wang Z,et al. Prevalence of Dyslipidemia Among Antiretroviral-Naive HIV-Infected Individuals in China[J]. Medicine (Baltimore),2015,94(48):1-8.
    [7]
    Jiang J,Qin X,Liu H,et al. An optimal BMI range associated with a lower risk of mortality among HIV-infected adults initiating antiretroviral therapy in Guangxi,China[J]. Sci Rep,2019,9(1):1-10.
    [8]
    徐小慧,单淑晴,时允,等. 云南省德宏州接受抗病毒治疗的HIV感染者高血压患病率及其影响因素[J]. 中国初级卫生保健,2020,34(4):48-51. doi: 10.3969/j.issn.1001-568X.2020.04.0015
    [9]
    Xu J F,Wang P C,Cheng F. Health related behaviors among HIV-infected people who are successfully linked to care:an institutional-based cross-sectional study[J]. Infect Dis Poverty,2020,9(1):1-9. doi: 10.1186/s40249-019-0617-6
    [10]
    眭维国,王磊. 代谢综合征与慢性肾脏病[J]. 国际泌尿系统杂志,2015,35(1):144-147. doi: 10.3760/cma.j.issn.1673-4416.2015.01.043
    [11]
    Wang Y,Sun B,Sheng L T,et al. Association between weight status,metabolic syndrome,and chronic kidney disease among middle-aged and elderly Chinese[J]. Nutr Metab Cardiovasc Dis,2020,30(11):2017-2026. doi: 10.1016/j.numecd.2020.06.025
    [12]
    Manaye G A,Abateneh D D,Niguse W. Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia[J]. HIV AIDS (Auckl),2020,12:591-599.
    [13]
    Rosenberg A Z,Naicker S,Winkler C A,et al. HIV-associated nephropathies:epidemiology,pathology,mechanisms and treatment[J]. Nat Rev Nephrol,2015,11(3):150-160. doi: 10.1038/nrneph.2015.9
    [14]
    Ascher S B,Scherzer R,Estrella M M,et al. Kidney tubule health scores and their associations with incident CKD in women living with HIV[J]. HIV Med,2021,22(7):527-537. doi: 10.1111/hiv.13081
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